Products

Refine

Country

Business Type

Certificate

Display

Luyunjia Chemistry Xiamen Limited

Overview Quick Details CAS No.: 78755-81-4 Other Names: Flumazenil MF: C15H14FN3O3 EINECS No.: 78755-81-4 Place of Origin: Shanghai, China (Mainland) Grade Standard: Agriculture Grade, Food Grade, Industrial Grade, Medicine Grade, Reagen

lower price Flumazenil 78755-81-4

Cas:78755-81-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Flumazenil Manufacturer/High quality/Best price/In stock

Cas:78755-81-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Our advantage--we provide EP6.0 Flumazenil and competitive price. (1) 28 year experience in pharmaceutical industry (2) ISO9001:2008 certificated company (3) Fischer Chemicals AG China office Basic information of Flumazenil EP6.0

CAS 78755-81-4 High Quality Flumazenil,EP6

Cas:78755-81-4

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Flumazenil 78755-81-4

Cas:78755-81-4

Min.Order:2 Gram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Flumazenil

Cas:78755-81-4

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Flumazenil 78755-81-4 GMP Manufacturer

Cas:78755-81-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Flumazenil CAS NO.78755-81-4

Cas:78755-81-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Flumazenil

Cas:78755-81-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu

Flumazenil manufacturer

Cas:78755-81-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

cas 78755-81-4 Central Nervous System Flumazenil API Powder

Cas:78755-81-4

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--78755-81-4--High purity Flumazenil factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business

TIANFUCHEM--78755-81-4--High purity Flumazenil factory price

Cas:78755-81-4

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 78755-81-4 with best quality

Cas:78755-81-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Flumazenil CAS78755-81-4

Cas:78755-81-4

Min.Order:1 Kilogram

FOB Price: $6.0 / 8.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Flumazenil

Cas:78755-81-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

FlumazenilCAS NO.: 78755-81-4

Cas:78755-81-4

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Colorless crystalline Powder Storage:Store in sealed contain

Romazicon Flumazenil USP 78755-81-4 Antidote Raw Material Powder

Cas:78755-81-4

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Flumazenil 78755-81-4

Cas:78755-81-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

GMP Factory Supply Flumazenil

Cas:78755-81-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Pharmaceutical Chemical Flumazenil Raw Powder Flumazenil 99% purity Flumazenil

Cas:78755-81-4

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Hefei TNJ chemical industry co.,ltd

1. One of the domestic largest manufacturers of API; 2. High quality,competitive price and delivery in time; 3. Supplier of safe and ecofriendly products ; 4. Stable supply and efficient service; 5. Cooperate with scientific

Manufacturer of Best Quality Flumazenil at Most Competitive Price

Cas:78755-81-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Appearance:White Powder Storage:Cool Dry Place Package: according to customers' requirements Application:Antibiotic and Antimicrobial Agents, Central Nervous System A Transportation:International express delivery Port: China main port

High quality API FlumazenilC

Cas:78755-81-4

Min.Order:1 Gram

FOB Price: $68.0 / 70.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Flumazenil CAS:78755-81-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Flumazenil CAS:78755-81-4

Cas:78755-81-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o

Hot Sale! Factory Supply High Quality Tranexamic Acid Raw Materials CAS 78755-81-4

Cas:78755-81-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many o

Flumazenil CAS 78755-81-4

Cas:78755-81-4

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

Lonwin Industry Group Limited. Lonwin Industry group limited as a professional manufactor & exporter of chemical materials ,we totally have more than 270 stuffs, we have been on this line for more than 9 years. Our chemical materials are expo

manufactory supply Flumazenil cas#78755-81-4

Cas:78755-81-4

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E

FLUMAZENIL

Cas:78755-81-4

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

Flumazenil

Cas:78755-81-4

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Flumazenil

Cas:78755-81-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Flumazenil Synonyms: Flumazenil、Flumazepil;FlumazenilUsDmf;ANEXATE;Flumazepil;FMZ;Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-α][1,4]benzodiazepine-3-carboxylate;Lanexat;Mazicon CAS: 78755-81-4 MF: C15H14FN3O

Flumazenil 99%

Cas:78755-81-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

78755-81-4 Flumazenil

Cas:78755-81-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester
428507-28-2

(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester

2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one
193693-31-1

2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Stage #1: (E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester With lithium hexamethyldisilazane In tetrahydrofuran at -35℃; for 1.5h;
Stage #2: 2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one With Dimethyl-p-toluidine In tetrahydrofuran at -40 - -35℃; for 3h;
Stage #3: With acetic acid In tetrahydrofuran for 6h; pH=5 - 7; Heating;
98%
ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one
193693-31-1

2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
With N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Reagent/catalyst; Solvent;61.3%
8-amino-5,6-dihydro-5-methyl-6-oxo-4H-imidazol[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
658075-93-5

8-amino-5,6-dihydro-5-methyl-6-oxo-4H-imidazol[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
With pyridine; hydrogen fluoride; sodium nitrite at 20 - 120℃; for 2.5h;51%
Multi-step reaction with 2 steps
1: BF3*Et2O; t-butyl nitrite / CH2Cl2 / -15 - 5 °C
2: 160 mg / 0.67 h / 130 °C
View Scheme
Ethyl isocyanoacetate
2999-46-4

Ethyl isocyanoacetate

7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
78755-80-3

7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Multistep reaction;
(dimethylamino-methyleneamino)-(7-fluoro-4-methyl-5-oxo-1,3,4,5-tetrahydro-benzo[e][1,4]diazepin-2-ylidene)-acetic acid ethyl ester

(dimethylamino-methyleneamino)-(7-fluoro-4-methyl-5-oxo-1,3,4,5-tetrahydro-benzo[e][1,4]diazepin-2-ylidene)-acetic acid ethyl ester

A

flumazenil
78755-81-4

flumazenil

B

(dimethylamino-methyleneamino)-(7-fluoro-4-methyl-5-oxo-1,3,4,5-tetrahydro-benzo[e][1,4]diazepin-2-ylidene)-acetic acid ethyl ester

(dimethylamino-methyleneamino)-(7-fluoro-4-methyl-5-oxo-1,3,4,5-tetrahydro-benzo[e][1,4]diazepin-2-ylidene)-acetic acid ethyl ester

Conditions
ConditionsYield
With acetic acid In tetrahydrofuran pH=5; Heating;
C15H14N5O3(1+)*BF4(1-)

C15H14N5O3(1+)*BF4(1-)

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
at 130℃; for 0.666667h; Balz-Schiemann reaction;160 mg
Ethyl isocyanoacetate
2999-46-4

Ethyl isocyanoacetate

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.79 g / sodium hydride / dimethylformamide; tetrahydrofuran / 18 h
2: 97 percent / H2 / Pd/C / tetrahydrofuran; ethanol / 2 h
3: BF3*Et2O; t-butyl nitrite / CH2Cl2 / -15 - 5 °C
4: 160 mg / 0.67 h / 130 °C
View Scheme
Multi-step reaction with 3 steps
1: N-methyl-acetamide; water; acetic acid; ethyl acetate
2: potassium carbonate / ethanol; water; trifluoroacetic acid
3: N-methyl-acetamide; water
View Scheme
7-nitro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dione
84377-96-8

7-nitro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dione

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium hydride; diethyl chlorophosphate / tetrahydrofuran; dimethylformamide / 0.5 h / 0 °C
2: 1.79 g / sodium hydride / dimethylformamide; tetrahydrofuran / 18 h
3: 97 percent / H2 / Pd/C / tetrahydrofuran; ethanol / 2 h
4: BF3*Et2O; t-butyl nitrite / CH2Cl2 / -15 - 5 °C
5: 160 mg / 0.67 h / 130 °C
View Scheme
8-nitro-5,6-dihydro-5-methyl-6-oxo-4H-imidazol[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
84377-97-9

8-nitro-5,6-dihydro-5-methyl-6-oxo-4H-imidazol[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / H2 / Pd/C / tetrahydrofuran; ethanol / 2 h
2: BF3*Et2O; t-butyl nitrite / CH2Cl2 / -15 - 5 °C
3: 160 mg / 0.67 h / 130 °C
View Scheme
2-chloro-4-methyl-7-nitro-3,4-dihydro-benzo[e][1,4]diazepin-5-one

2-chloro-4-methyl-7-nitro-3,4-dihydro-benzo[e][1,4]diazepin-5-one

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.79 g / sodium hydride / dimethylformamide; tetrahydrofuran / 18 h
2: 97 percent / H2 / Pd/C / tetrahydrofuran; ethanol / 2 h
3: BF3*Et2O; t-butyl nitrite / CH2Cl2 / -15 - 5 °C
4: 160 mg / 0.67 h / 130 °C
View Scheme
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
78755-80-3

7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C
2.1: LHMDS / tetrahydrofuran / 1.5 h / -35 °C
2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / 3 h / -40 - -35 °C
2.3: 98 percent / acetic acid / tetrahydrofuran / 6 h / pH 5 - 7 / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C
2.1: LHMDS / tetrahydrofuran / 2 h / -30 °C
2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C / pH 7
3.1: acetic acid / tetrahydrofuran / pH 5 / Heating
View Scheme
(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester
428507-28-2

(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: LHMDS / tetrahydrofuran / 2 h / -30 °C
1.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C / pH 7
2.1: acetic acid / tetrahydrofuran / pH 5 / Heating
View Scheme
2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one
193693-31-1

2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: LHMDS / tetrahydrofuran / 2 h / -30 °C
1.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C / pH 7
2.1: acetic acid / tetrahydrofuran / pH 5 / Heating
View Scheme
1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

Dimethyl-p-toluidine
99-97-8

Dimethyl-p-toluidine

(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester
428507-28-2

(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester

2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one
193693-31-1

2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
With n-butyllithium; sodium hydrogencarbonate; acetic acid In tetrahydrofuran; ethanol; n-heptane; dichloromethane
ethyl N-<(dimethylamino)methylene>glycinate
30766-78-0

ethyl N-<(dimethylamino)methylene>glycinate

1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

Dimethyl-p-toluidine
99-97-8

Dimethyl-p-toluidine

2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one
193693-31-1

2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
With n-butyllithium; sodium hydrogencarbonate; acetic acid In tetrahydrofuran; n-heptane; dichloromethane
Ethyl isocyanoacetate
2999-46-4

Ethyl isocyanoacetate

potassium tert-butylate
865-47-4

potassium tert-butylate

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
78755-80-3

7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
In N-methyl-acetamide; water; acetic acid
dichloroamine
3400-09-7

dichloroamine

Ethyl isocyanoacetate
2999-46-4

Ethyl isocyanoacetate

potassium tert-butylate
865-47-4

potassium tert-butylate

7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
78755-80-3

7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
With sodium hydrogencarbonate; acetic acid; trichlorophosphate In N-methyl-acetamide; chloroform; water; 2,3-Dimethylaniline
ethyl 8-fluoro-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
79089-72-8

ethyl 8-fluoro-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
In N-methyl-acetamide; water
Ethyl isocyanoacetate
2999-46-4

Ethyl isocyanoacetate

C14H18FN2O5P

C14H18FN2O5P

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -35 - 20℃; Inert atmosphere;2 g
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(4-methylphenyl)iodonium tosylate
1350523-27-1

(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(4-methylphenyl)iodonium tosylate

A

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
78756-03-3

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate

B

flumazenil
78755-81-4

flumazenil

C

Ro 41-8157
268566-09-2

Ro 41-8157

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h;
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(phenyl)iodonium tosylate
1350523-17-9

(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(phenyl)iodonium tosylate

A

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
78756-03-3

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate

B

flumazenil
78755-81-4

flumazenil

C

Ro 41-8157
268566-09-2

Ro 41-8157

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h;
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(2-thiophenyl)iodonium tosylate
1350523-19-1

(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(2-thiophenyl)iodonium tosylate

A

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
78756-03-3

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate

B

flumazenil
78755-81-4

flumazenil

C

Ro 41-8157
268566-09-2

Ro 41-8157

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h;
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(3-thiophenyl)iodonium tosylate
1350523-21-5

(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(3-thiophenyl)iodonium tosylate

A

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
78756-03-3

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate

B

flumazenil
78755-81-4

flumazenil

C

Ro 41-8157
268566-09-2

Ro 41-8157

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h;
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(4-methoxyphenyl)iodonium tosylate
1350523-23-7

(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(4-methoxyphenyl)iodonium tosylate

A

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
78756-03-3

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate

B

flumazenil
78755-81-4

flumazenil

C

Ro 41-8157
268566-09-2

Ro 41-8157

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h;
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(3-methoxyphenyl)iodonium tosylate
1350523-25-9

(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(3-methoxyphenyl)iodonium tosylate

A

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
78756-03-3

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate

B

flumazenil
78755-81-4

flumazenil

C

Ro 41-8157
268566-09-2

Ro 41-8157

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h;
ethyl 5,6-dihydro-5-methyl-6-oxo-8-tributylstannyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
200408-05-5

ethyl 5,6-dihydro-5-methyl-6-oxo-8-tributylstannyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

A

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
78756-03-3

ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate

B

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane; acetonitrile / 20 h / 20 °C / Inert atmosphere
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride / N,N-dimethyl-formamide; acetonitrile / 2 h / 90 °C
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane; acetonitrile / 20 h / 20 °C / Inert atmosphere
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride / N,N-dimethyl-formamide; acetonitrile / 2 h / 90 °C
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane; acetonitrile / 20 h / 20 °C / Inert atmosphere
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride / N,N-dimethyl-formamide; acetonitrile / 2 h / 90 °C
View Scheme
4-(2,4-dimethoxybenzyl)-7-fluoro-3,4-dihydro-2H-1,4-benzodiazepine-2,5(1H)-dione

4-(2,4-dimethoxybenzyl)-7-fluoro-3,4-dihydro-2H-1,4-benzodiazepine-2,5(1H)-dione

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-methyl-acetamide; water; acetic acid; ethyl acetate
2: potassium carbonate / ethanol; water; trifluoroacetic acid
3: N-methyl-acetamide; water
View Scheme
ethyl 5-(2,4-dimethoxybenzyl)-8-fluoro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

ethyl 5-(2,4-dimethoxybenzyl)-8-fluoro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

flumazenil
78755-81-4

flumazenil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / ethanol; water; trifluoroacetic acid
2: N-methyl-acetamide; water
View Scheme
flumazenil
78755-81-4

flumazenil

8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid
84378-44-9

8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: flumazenil With sodium hydroxide In tetrahydrofuran; water at 20℃;
Stage #2: With hydrogenchloride In water
100%
With tetra(n-butyl)ammonium hydroxide; water Hydrolysis;
flumazenil
78755-81-4

flumazenil

C15H13(2)HFN3O3

C15H13(2)HFN3O3

Conditions
ConditionsYield
With [(N,N′-bis(2,6-diisopropylphenyl)-2,3-butanediimine)Ni(μ−H)]2; deuterium In tetrahydrofuran at -196 - 45℃; under 760.051 Torr; for 24h; Reagent/catalyst; Sealed tube;100%
With ethyl [2]alcohol; di(tertbutyl)phenylphosphine; silver carbonate In dichloromethane at 50 - 80℃; Inert atmosphere;69%
flumazenil
78755-81-4

flumazenil

C15H10(2)H4FN3O3

C15H10(2)H4FN3O3

Conditions
ConditionsYield
With [(N,N’-bis(1R,2R,3R,5S)-(−)-isopinocampheyl-1,2-ethanediimine-radical)NiI(μ2-H)]2; deuterium In tetrahydrofuran at -196 - 45℃; under 760.051 Torr; for 24h; Reagent/catalyst; Sealed tube;98%
flumazenil
78755-81-4

flumazenil

ethyl 6-cyano-8-fluoro-5-methyl-5,6-dihydro-4Hbenzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

ethyl 6-cyano-8-fluoro-5-methyl-5,6-dihydro-4Hbenzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

Conditions
ConditionsYield
Stage #1: flumazenil With bis(triphenylphosphine)iridium(I) carbonyl chloride In toluene at 20℃; for 0.0833333h;
Stage #2: With 1,1,3,3-Tetramethyldisiloxane In toluene at 20℃; for 0.0833333h;
Stage #3: With trimethylsilyl cyanide In toluene at 20℃; for 0.5h;
47%
isobutyramide oxime
35613-84-4

isobutyramide oxime

flumazenil
78755-81-4

flumazenil

8-Fluoro-3-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-5-methyl-4,5-dihydro-2,5,10b-triaza-benzo[e]azulen-6-one

8-Fluoro-3-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-5-methyl-4,5-dihydro-2,5,10b-triaza-benzo[e]azulen-6-one

Conditions
ConditionsYield
With molecular sieve; sodium hydride 1) THF, r.t., 2) THF, reflux; Yield given. Multistep reaction;
flumazenil
78755-81-4

flumazenil

8-fluoro-5,6-dihydro-5-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one

8-fluoro-5,6-dihydro-5-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one

Conditions
ConditionsYield
With molecular sieve; sodium hydride 1) THF, r.t., 2) THF, reflux; Yield given. Multistep reaction;
flumazenil
78755-81-4

flumazenil

N-hydroxypropanimidamide
29335-36-2

N-hydroxypropanimidamide

FG 8006

FG 8006

Conditions
ConditionsYield
With molecular sieve; sodium hydride 1) THF, r.t., 2) THF, reflux; Yield given. Multistep reaction;
flumazenil
78755-81-4

flumazenil

butyramide oxime
27620-10-6

butyramide oxime

8-Fluoro-5-methyl-3-(3-propyl-[1,2,4]oxadiazol-5-yl)-4,5-dihydro-2,5,10b-triaza-benzo[e]azulen-6-one

8-Fluoro-5-methyl-3-(3-propyl-[1,2,4]oxadiazol-5-yl)-4,5-dihydro-2,5,10b-triaza-benzo[e]azulen-6-one

Conditions
ConditionsYield
With molecular sieve; sodium hydride 1) THF, r.t., 2) THF, reflux; Yield given. Multistep reaction;
flumazenil
78755-81-4

flumazenil

[18F]flumanezil

[18F]flumanezil

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; potassium hydrogencarbonate In water; acetonitrile at 160℃; under 375.03 Torr;
With potassium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA In dimethyl sulfoxide at 130℃;
flumazenil
78755-81-4

flumazenil

2-[(p-toluenesulfonyl)oxy]ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
676437-17-5

2-[(p-toluenesulfonyl)oxy]ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrabutylammonium hydroxide; water
2: 63 percent / tetrabutylammonium hydroxide / CH2Cl2
View Scheme
flumazenil
78755-81-4

flumazenil

isopropyl alcohol
67-63-0

isopropyl alcohol

isopropyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

isopropyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

flumazenil
78755-81-4

flumazenil

ethylene glycol
107-21-1

ethylene glycol

(2-hydroxyethyl) 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

(2-hydroxyethyl) 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Conditions
ConditionsYield
In chloroform; ethyl acetate
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View