Overview Quick Details CAS No.: 78755-81-4 Other Names: Flumazenil MF: C15H14FN3O3 EINECS No.: 78755-81-4 Place of Origin: Shanghai, China (Mainland) Grade Standard: Agriculture Grade, Food Grade, Industrial Grade, Medicine Grade, Reagen
Cas:78755-81-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:78755-81-4
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryOur advantage--we provide EP6.0 Flumazenil and competitive price. (1) 28 year experience in pharmaceutical industry (2) ISO9001:2008 certificated company (3) Fischer Chemicals AG China office Basic information of Flumazenil EP6.0
Cas:78755-81-4
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:78755-81-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:78755-81-4
Min.Order:1 Kilogram
FOB Price: $1.0 / 3.0
Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu
Cas:78755-81-4
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
Cas:78755-81-4
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Trading Company
inquiryTIANFUCHEM--78755-81-4--High purity Flumazenil factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business
Cas:78755-81-4
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:78755-81-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:78755-81-4
Min.Order:1 Kilogram
FOB Price: $6.0 / 8.0
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:78755-81-4
Min.Order:1 Gram
FOB Price: $2.0
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Colorless crystalline Powder Storage:Store in sealed contain
Cas:78755-81-4
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:78755-81-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
Cas:78755-81-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Trading Company
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:78755-81-4
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiry1. One of the domestic largest manufacturers of API; 2. High quality,competitive price and delivery in time; 3. Supplier of safe and ecofriendly products ; 4. Stable supply and efficient service; 5. Cooperate with scientific
Cas:78755-81-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryAppearance:White Powder Storage:Cool Dry Place Package: according to customers' requirements Application:Antibiotic and Antimicrobial Agents, Central Nervous System A Transportation:International express delivery Port: China main port
Cas:78755-81-4
Min.Order:1 Gram
FOB Price: $68.0 / 70.0
Type:Trading Company
inquiryFlumazenil CAS:78755-81-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:78755-81-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o
Cas:78755-81-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryHebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many o
Cas:78755-81-4
Min.Order:1 Kilogram
FOB Price: $20.0 / 40.0
Type:Trading Company
inquiryLonwin Industry Group Limited. Lonwin Industry group limited as a professional manufactor & exporter of chemical materials ,we totally have more than 270 stuffs, we have been on this line for more than 9 years. Our chemical materials are expo
Cas:78755-81-4
Min.Order:100 Kilogram
FOB Price: $100.0 / 150.0
Type:Other
inquiry1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E
Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio
Cas:78755-81-4
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:78755-81-4
Min.Order:1 Kilogram
FOB Price: $1.0 / 100000.0
Type:Lab/Research institutions
inquiryProduct Name: Flumazenil Synonyms: Flumazenil、Flumazepil;FlumazenilUsDmf;ANEXATE;Flumazepil;FMZ;Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-α][1,4]benzodiazepine-3-carboxylate;Lanexat;Mazicon CAS: 78755-81-4 MF: C15H14FN3O
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester
2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one
flumazenil
Conditions | Yield |
---|---|
Stage #1: (E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester With lithium hexamethyldisilazane In tetrahydrofuran at -35℃; for 1.5h; Stage #2: 2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one With Dimethyl-p-toluidine In tetrahydrofuran at -40 - -35℃; for 3h; Stage #3: With acetic acid In tetrahydrofuran for 6h; pH=5 - 7; Heating; | 98% |
ethyl 2-cyanoacetate
2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one
flumazenil
Conditions | Yield |
---|---|
With N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Reagent/catalyst; Solvent; | 61.3% |
8-amino-5,6-dihydro-5-methyl-6-oxo-4H-imidazol[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
flumazenil
Conditions | Yield |
---|---|
With pyridine; hydrogen fluoride; sodium nitrite at 20 - 120℃; for 2.5h; | 51% |
Multi-step reaction with 2 steps 1: BF3*Et2O; t-butyl nitrite / CH2Cl2 / -15 - 5 °C 2: 160 mg / 0.67 h / 130 °C View Scheme |
Ethyl isocyanoacetate
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
flumazenil
Conditions | Yield |
---|---|
Multistep reaction; |
A
flumazenil
Conditions | Yield |
---|---|
With acetic acid In tetrahydrofuran pH=5; Heating; |
flumazenil
Conditions | Yield |
---|---|
at 130℃; for 0.666667h; Balz-Schiemann reaction; | 160 mg |
Ethyl isocyanoacetate
flumazenil
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.79 g / sodium hydride / dimethylformamide; tetrahydrofuran / 18 h 2: 97 percent / H2 / Pd/C / tetrahydrofuran; ethanol / 2 h 3: BF3*Et2O; t-butyl nitrite / CH2Cl2 / -15 - 5 °C 4: 160 mg / 0.67 h / 130 °C View Scheme | |
Multi-step reaction with 3 steps 1: N-methyl-acetamide; water; acetic acid; ethyl acetate 2: potassium carbonate / ethanol; water; trifluoroacetic acid 3: N-methyl-acetamide; water View Scheme |
7-nitro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dione
flumazenil
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium hydride; diethyl chlorophosphate / tetrahydrofuran; dimethylformamide / 0.5 h / 0 °C 2: 1.79 g / sodium hydride / dimethylformamide; tetrahydrofuran / 18 h 3: 97 percent / H2 / Pd/C / tetrahydrofuran; ethanol / 2 h 4: BF3*Et2O; t-butyl nitrite / CH2Cl2 / -15 - 5 °C 5: 160 mg / 0.67 h / 130 °C View Scheme |
8-nitro-5,6-dihydro-5-methyl-6-oxo-4H-imidazol[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
flumazenil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 97 percent / H2 / Pd/C / tetrahydrofuran; ethanol / 2 h 2: BF3*Et2O; t-butyl nitrite / CH2Cl2 / -15 - 5 °C 3: 160 mg / 0.67 h / 130 °C View Scheme |
flumazenil
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.79 g / sodium hydride / dimethylformamide; tetrahydrofuran / 18 h 2: 97 percent / H2 / Pd/C / tetrahydrofuran; ethanol / 2 h 3: BF3*Et2O; t-butyl nitrite / CH2Cl2 / -15 - 5 °C 4: 160 mg / 0.67 h / 130 °C View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
flumazenil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2.1: LHMDS / tetrahydrofuran / 1.5 h / -35 °C 2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / 3 h / -40 - -35 °C 2.3: 98 percent / acetic acid / tetrahydrofuran / 6 h / pH 5 - 7 / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C / pH 7 3.1: acetic acid / tetrahydrofuran / pH 5 / Heating View Scheme |
(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester
flumazenil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 1.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C / pH 7 2.1: acetic acid / tetrahydrofuran / pH 5 / Heating View Scheme |
2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one
flumazenil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 1.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C / pH 7 2.1: acetic acid / tetrahydrofuran / pH 5 / Heating View Scheme |
1,1,1,3,3,3-hexamethyl-disilazane
Dimethyl-p-toluidine
(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester
2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one
flumazenil
Conditions | Yield |
---|---|
With n-butyllithium; sodium hydrogencarbonate; acetic acid In tetrahydrofuran; ethanol; n-heptane; dichloromethane |
ethyl N-<(dimethylamino)methylene>glycinate
1,1,1,3,3,3-hexamethyl-disilazane
Dimethyl-p-toluidine
2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one
flumazenil
Conditions | Yield |
---|---|
With n-butyllithium; sodium hydrogencarbonate; acetic acid In tetrahydrofuran; n-heptane; dichloromethane |
Ethyl isocyanoacetate
potassium tert-butylate
diethyl chlorophosphate
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
flumazenil
Conditions | Yield |
---|---|
In N-methyl-acetamide; water; acetic acid |
dichloroamine
Ethyl isocyanoacetate
potassium tert-butylate
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
flumazenil
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; acetic acid; trichlorophosphate In N-methyl-acetamide; chloroform; water; 2,3-Dimethylaniline |
ethyl 8-fluoro-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
flumazenil
Conditions | Yield |
---|---|
In N-methyl-acetamide; water |
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at -35 - 20℃; Inert atmosphere; | 2 g |
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(4-methylphenyl)iodonium tosylate
A
ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
B
flumazenil
C
Ro 41-8157
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h; |
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(phenyl)iodonium tosylate
A
ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
B
flumazenil
C
Ro 41-8157
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h; |
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(2-thiophenyl)iodonium tosylate
A
ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
B
flumazenil
C
Ro 41-8157
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h; |
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(3-thiophenyl)iodonium tosylate
A
ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
B
flumazenil
C
Ro 41-8157
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h; |
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(4-methoxyphenyl)iodonium tosylate
A
ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
B
flumazenil
C
Ro 41-8157
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h; |
(3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(3-methoxyphenyl)iodonium tosylate
A
ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
B
flumazenil
C
Ro 41-8157
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride In N,N-dimethyl-formamide; acetonitrile at 90℃; for 2h; |
ethyl 5,6-dihydro-5-methyl-6-oxo-8-tributylstannyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
A
ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
B
flumazenil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dichloromethane; acetonitrile / 20 h / 20 °C / Inert atmosphere 2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride / N,N-dimethyl-formamide; acetonitrile / 2 h / 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: dichloromethane; acetonitrile / 20 h / 20 °C / Inert atmosphere 2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride / N,N-dimethyl-formamide; acetonitrile / 2 h / 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: dichloromethane; acetonitrile / 20 h / 20 °C / Inert atmosphere 2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cesium fluoride / N,N-dimethyl-formamide; acetonitrile / 2 h / 90 °C View Scheme |
flumazenil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-methyl-acetamide; water; acetic acid; ethyl acetate 2: potassium carbonate / ethanol; water; trifluoroacetic acid 3: N-methyl-acetamide; water View Scheme |
flumazenil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / ethanol; water; trifluoroacetic acid 2: N-methyl-acetamide; water View Scheme |
flumazenil
8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: flumazenil With sodium hydroxide In tetrahydrofuran; water at 20℃; Stage #2: With hydrogenchloride In water | 100% |
With tetra(n-butyl)ammonium hydroxide; water Hydrolysis; |
flumazenil
Conditions | Yield |
---|---|
With [(N,N′-bis(2,6-diisopropylphenyl)-2,3-butanediimine)Ni(μ−H)]2; deuterium In tetrahydrofuran at -196 - 45℃; under 760.051 Torr; for 24h; Reagent/catalyst; Sealed tube; | 100% |
With ethyl [2]alcohol; di(tertbutyl)phenylphosphine; silver carbonate In dichloromethane at 50 - 80℃; Inert atmosphere; | 69% |
flumazenil
Conditions | Yield |
---|---|
With [(N,N’-bis(1R,2R,3R,5S)-(−)-isopinocampheyl-1,2-ethanediimine-radical)NiI(μ2-H)]2; deuterium In tetrahydrofuran at -196 - 45℃; under 760.051 Torr; for 24h; Reagent/catalyst; Sealed tube; | 98% |
flumazenil
Conditions | Yield |
---|---|
Stage #1: flumazenil With bis(triphenylphosphine)iridium(I) carbonyl chloride In toluene at 20℃; for 0.0833333h; Stage #2: With 1,1,3,3-Tetramethyldisiloxane In toluene at 20℃; for 0.0833333h; Stage #3: With trimethylsilyl cyanide In toluene at 20℃; for 0.5h; | 47% |
isobutyramide oxime
flumazenil
Conditions | Yield |
---|---|
With molecular sieve; sodium hydride 1) THF, r.t., 2) THF, reflux; Yield given. Multistep reaction; |
flumazenil
acetamide oxime
Conditions | Yield |
---|---|
With molecular sieve; sodium hydride 1) THF, r.t., 2) THF, reflux; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With molecular sieve; sodium hydride 1) THF, r.t., 2) THF, reflux; Yield given. Multistep reaction; |
flumazenil
butyramide oxime
Conditions | Yield |
---|---|
With molecular sieve; sodium hydride 1) THF, r.t., 2) THF, reflux; Yield given. Multistep reaction; |
flumazenil
Conditions | Yield |
---|---|
With 2,4,6-trimethyl-pyridine; potassium hydrogencarbonate In water; acetonitrile at 160℃; under 375.03 Torr; | |
With potassium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA In dimethyl sulfoxide at 130℃; |
flumazenil
2-[(p-toluenesulfonyl)oxy]ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetrabutylammonium hydroxide; water 2: 63 percent / tetrabutylammonium hydroxide / CH2Cl2 View Scheme |
flumazenil
isopropyl alcohol
flumazenil
ethylene glycol
Conditions | Yield |
---|---|
In chloroform; ethyl acetate |
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