Product Description Product website: http://www.finerchem.com/pro01en/id/221.html Product Name 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-
Cas:898543-06-1
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% -----------------------------------------------------------------------------------------------------------
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or off-white crystalline powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceut
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiry(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl Manufacturer Factory CAS 898543-06-1 (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl Manufacturer High quality Best price In stock factory CAS 898
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inquiryTIANFUCHEM--898543-06-1-- (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryName 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone hydrochloride Synonyms 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholin-3-one hydrochlori
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystal powder Storage:Store in sealed container
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inquiry(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl CAS:898543-06-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical in
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inquiry4-[4-[(5S)-5-(Aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholin-3-one hydrochloride CAS: 898543-06-1 Specification Items Specification Product name (S)-4-(4-(5-(Aminomethyl)-2-oxooxazoli
Cas:898543-06-1
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:898543-06-1
Min.Order:4 Kilogram
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiry1. made in GMP plant, commerially 2. usually have it in stock 3. can supply at large quantity 4. audit accepted. related documents are available to offer and audited by many clients, such as lupin, msn, dr reddy etc 5. chromatographic p
Cas:898543-06-1
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inquiry2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Stage #1: 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione With methylamine In N,N-dimethyl-formamide at 60 - 65℃; for 5h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 40℃; Temperature; Solvent; | 96% |
Stage #1: 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione With methylamine In methanol; water at 25 - 65℃; for 5h; Stage #2: With hydrogenchloride In methanol; water at 25 - 30℃; for 0.5h; pH=1 - 2; Temperature; | 92% |
Stage #1: 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione With methylamine In ethanol; water at 40 - 60℃; for 8h; Stage #2: With hydrogenchloride In water at 15℃; for 2h; | 89.7% |
(S)-4-(4-{5-[(benzylidene-amino)-methyl]-2-oxo-oxazolidine-3-yl}-phenyl)-morpholin-3-one
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water at 0 - 15℃; for 0.75h; pH=2; Temperature; pH-value; | 92.4% |
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
methylamine
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Stage #1: 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione; methylamine In ethanol for 1h; Reflux; Large scale; Stage #2: With hydrogenchloride In ethanol at 50 - 60℃; pH=2 - Ca. 3; Large scale; | 90.3% |
4-{4-[(5S)-5-((dibenzylamino)methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Stage #1: 4-{4-[(5S)-5-((dibenzylamino)methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one With palladium 10% on activated carbon; hydrogen In methanol at 40℃; for 6h; Stage #2: With hydrogenchloride In methanol for 4h; Reagent/catalyst; | 90.2% |
2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
1,1'-carbonyldiimidazole
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Stage #1: 2-((2S)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione; 1,1'-carbonyldiimidazole With dmap In tetrahydrofuran for 12h; Reflux; Stage #2: With hydrogenchloride In water at 20℃; Concentration; | 89.1% |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol at 55℃; for 2h; | 85% |
(S)-4-(4-((3-amino-2-hydroxypropyl)amino)phenyl)morpholin-3-one hydrochloride
1,1'-carbonyldiimidazole
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-4-(4-((3-amino-2-hydroxypropyl)amino)phenyl)morpholin-3-one hydrochloride With potassium carbonate In 4-methyl-2-pentanone at 4℃; Inert atmosphere; Reflux; Stage #2: 1,1'-carbonyldiimidazole In 4-methyl-2-pentanone at 20℃; for 15h; Stage #3: With hydrogenchloride In water; 4-methyl-2-pentanone | 80.1% |
1-{(R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-ylmethyl}-3;5,7-triaza-1-azoniatricyclo[3.3.1.1(3,7)]decane iodide
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; water In ethanol at 50℃; for 2h; Inert atmosphere; | 33.1% |
4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)amino)phenyl]morpholin-3-one
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: ammonia / water / 4 h / 20 °C 2.1: potassium carbonate / 4-methyl-2-pentanone / 4 °C / Inert atmosphere; Reflux 2.2: 15 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: acetonitrile / 3 h / 20 °C / Inert atmosphere 2: sodium iodide / sulfolane / 20 h / 110 °C 3: sulfolane / 72 h / 50 °C / Inert atmosphere 4: hydrogenchloride; water / ethanol / 2 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 2 h / 100 °C 2: potassium carbonate / ethanol / 2 h / 60 °C 3: hydrogenchloride / ethanol / 2 h / 55 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: methanol / 10 h / Reflux 2.1: dmap / tetrahydrofuran / 12 h / Reflux 2.2: 20 °C View Scheme |
4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium iodide / sulfolane / 20 h / 110 °C 2: sulfolane / 72 h / 50 °C / Inert atmosphere 3: hydrogenchloride; water / ethanol / 2 h / 50 °C / Inert atmosphere View Scheme |
4-[4-((R)-5-(iodomethyl)-2-oxo-oxazolidin-3-yl)phenyl]-morpholin-3-one
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfolane / 72 h / 50 °C / Inert atmosphere 2: hydrogenchloride; water / ethanol / 2 h / 50 °C / Inert atmosphere View Scheme |
2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 4 h / Reflux 2.1: methylamine / ethanol; water / 2 h / 65 °C 2.2: 65 °C / pH 2.7 View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium carbonate / dichloromethane / 5 h / 20 °C 2.1: methylamine / methanol / 6 h / 25 °C / Reflux 2.2: 1 h / 25 - 30 °C / pH 2 - 3 View Scheme | |
Multi-step reaction with 2 steps 1.1: dichloromethane / 8 h / 25 - 30 °C 2.1: methylamine / water; methanol / 5 h / 25 - 65 °C 2.2: 0.5 h / 25 - 30 °C / pH 1 - 2 View Scheme | |
Multi-step reaction with 2 steps 1.1: dmap / tetrahydrofuran / 25 h / Reflux; Large scale 2.1: ethanol / 1 h / Reflux; Large scale 2.2: 50 - 60 °C / pH 2 - Ca. 3 / Large scale View Scheme |
4-(4-aminophenyl)morpholin-3-one
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ethanol / 9 h / 80 °C 2.1: tetrahydrofuran / 4 h / Reflux 3.1: methylamine / ethanol; water / 2 h / 65 °C 3.2: 65 °C / pH 2.7 View Scheme | |
Multi-step reaction with 3 steps 1.1: isopropyl alcohol; water / Reflux 2.1: potassium carbonate / dichloromethane / 5 h / 20 °C 3.1: methylamine / methanol / 6 h / 25 °C / Reflux 3.2: 1 h / 25 - 30 °C / pH 2 - 3 View Scheme | |
Multi-step reaction with 3 steps 1: ethanol / 24 h / Reflux 2: dichloromethane / 44 h / 20 °C 3: hydrogenchloride / methanol / 1 h / 20 °C View Scheme |
tert-butyl {(5S)-3-[4-(3-oxo-4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 20℃; for 1h; | 26.5 g |
tert-butyl N-[(R)-2-hydroxy-3-{4-(3-oxomorpholin-4-yl)phenylamino}propyl]carbamate
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dichloromethane / 44 h / 20 °C 2: hydrogenchloride / methanol / 1 h / 20 °C View Scheme |
[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium tert-butoxide / N,N-dimethyl-formamide; methanol / 18 h / 0 - 25 °C 2: hydrogenchloride / methanol / 1 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: lithium tert-butoxide / tetrahydrofuran / 48 h / 0 - 25 °C 2: hydrogenchloride / methanol / 1 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: lithium tert-butoxide / N,N-dimethyl-formamide; tetrahydrofuran / 44 h / 20 °C / Cooling with ice 2: hydrogenchloride / methanol / 1 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: lithium tert-butoxide; lithium chloride / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere 2: hydrogenchloride / water / 0.75 h / 0 - 15 °C / pH 2 View Scheme |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
With methylamine In dichloromethane; water at 20 - 45℃; for 15h; Solvent; | 58 g |
para-nitrophenyl bromide
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: potassium carbonate / acetonitrile / 18 h / 60 °C 1.2: 2 h / 60 °C 2.1: iron; acetic acid / acetonitrile / 3 h / 30 °C 3.1: ethanol / 12 h / Reflux 4.1: N,N-dimethyl-formamide / 2 h / 100 °C 5.1: potassium carbonate / ethanol / 2 h / 60 °C 6.1: hydrogenchloride / ethanol / 2 h / 55 °C View Scheme |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / ethanol / 2 h / 60 °C 2: hydrogenchloride / ethanol / 2 h / 55 °C View Scheme |
4-chlorobenzonitrile
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: potassium carbonate / acetonitrile / 6 h / 60 °C 1.2: 2 h / 60 °C 2.1: iron; acetic acid / acetonitrile / 3 h / 30 °C 3.1: ethanol / 12 h / Reflux 4.1: N,N-dimethyl-formamide / 2 h / 100 °C 5.1: potassium carbonate / ethanol / 2 h / 60 °C 6.1: hydrogenchloride / ethanol / 2 h / 55 °C View Scheme |
4-(4-nitrophenyl)-3-morpholinone
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: iron; acetic acid / acetonitrile / 3 h / 30 °C 2: ethanol / 12 h / Reflux 3: N,N-dimethyl-formamide / 2 h / 100 °C 4: potassium carbonate / ethanol / 2 h / 60 °C 5: hydrogenchloride / ethanol / 2 h / 55 °C View Scheme |
4-Fluoronitrobenzene
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: potassium carbonate / acetonitrile / 18 h / 60 °C 1.2: 2 h / 60 °C 2.1: iron; acetic acid / acetonitrile / 3 h / 30 °C 3.1: ethanol / 12 h / Reflux 4.1: N,N-dimethyl-formamide / 2 h / 100 °C 5.1: potassium carbonate / ethanol / 2 h / 60 °C 6.1: hydrogenchloride / ethanol / 2 h / 55 °C View Scheme |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: lithium tert-butoxide / dichloromethane / 0.5 h / 5 - 20 °C / Reflux; Large scale 1.2: 12 h / Large scale 2.1: hydrogenchloride / water; ethanol / 1.5 h / 20 °C / pH 2 - 3 / Large scale View Scheme |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 20℃; for 1.5h; pH=2 - 3; Large scale; | 1.45 kg |
1,4-phenylenediamine
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: pyridine / tetrahydrofuran / 5 h / 10 - 20 °C 2.1: tetrabutylammomium bromide; potassium carbonate / dichloromethane / 5 h / 0 - 20 °C 3.1: isopropyl alcohol / 17 h / Reflux 4.1: methanol / 10 h / Reflux 5.1: dmap / tetrahydrofuran / 12 h / Reflux 5.2: 20 °C View Scheme |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: tetrabutylammomium bromide; potassium carbonate / dichloromethane / 5 h / 0 - 20 °C 2.1: isopropyl alcohol / 17 h / Reflux 3.1: methanol / 10 h / Reflux 4.1: dmap / tetrahydrofuran / 12 h / Reflux 4.2: 20 °C View Scheme |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 7 h / 0 - 5 °C 2.1: methylamine / ethanol; water / 8 h / 40 - 60 °C 2.2: 2 h / 15 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 7 h / 0 - 5 °C 2.1: methylamine / ethanol; water / 8 h / 40 - 60 °C 2.2: 15 °C / pH 1 - 2 View Scheme |
methyl N-[4-(3-oxo-4-morpholinyl)phenyl]carbamate
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium chloride; lithium hexamethyldisilazane / tetrahydrofuran / 12 h / 30 °C / Inert atmosphere 2: hydrogenchloride / water / 0.75 h / 0 - 15 °C / pH 2 View Scheme |
4-bromo-aniline
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: copper(l) iodide; N,N`-dimethylethylenediamine; potassium carbonate / toluene / Inert atmosphere 2: sodium hydrogencarbonate / dichloromethane / 4 h / 25 °C 3: lithium tert-butoxide; lithium chloride / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere 4: hydrogenchloride / water / 0.75 h / 0 - 15 °C / pH 2 View Scheme |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
In dichloromethane; water pH=8; Concentration; | 96.7% |
With potassium carbonate In methanol at 25 - 30℃; for 0.5h; | 56% |
With potassium carbonate In methanol at 25 - 30℃; for 0.5h; | 56% |
With potassium carbonate In water at 20℃; for 2h; |
5-Chlorothiophene-2-carboxylic acid
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Rivaroxaban
Conditions | Yield |
---|---|
Stage #1: 5-Chlorothiophene-2-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 25℃; for 0.5h; Stage #2: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride In N,N-dimethyl-formamide at 34℃; for 4h; | 96.3% |
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 2.83333h; Reagent/catalyst; Cooling with ice; | 95.2% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 24h; pH=8 - 9; Large scale; | 94.7% |
5-chlorothiophene-2-carboxylic acid chloride
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Rivaroxaban
Conditions | Yield |
---|---|
With triethylamine In water; acetone; toluene at 30 - 35℃; for 2h; Temperature; Concentration; | 93.3% |
5-chlorothiophene-2-carbonyl chloride
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Rivaroxaban
Conditions | Yield |
---|---|
With sodium carbonate In water; acetone; toluene at 8 - 53℃; | 93.12% |
With sodium carbonate In water; acetone; toluene at 10 - 53℃; for 0.5h; High pressure; | 90% |
With potassium carbonate In dichloromethane at 25 - 30℃; for 5h; | 88% |
5-chlorothiophene-2-carbonyl chloride
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
5-chloro-N-({(5)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 2h; Heating; | 85% |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
4-nitrophenyl 5-chlorothiophene-2-carboxylate
Rivaroxaban
Conditions | Yield |
---|---|
With triethylamine In dimethyl sulfoxide at 35 - 40℃; Reagent/catalyst; Solvent; Temperature; | 82.7% |
With triethylamine In dimethyl sulfoxide; acetonitrile at 35 - 40℃; | 82.7% |
4,5-dichlorothiophene-2-carbonyl chloride
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Conditions | Yield |
---|---|
With sodium carbonate In water; acetone at 20℃; | 82.1% |
With sodium carbonate In water; toluene at 8 - 20℃; for 2h; |
formic acid
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide
Conditions | Yield |
---|---|
Stage #1: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride With ammonia In dichloromethane for 0.25h; Stage #2: formic acid In water; toluene at 110 - 120℃; | 80% |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
4-Fluoronitrobenzene
Conditions | Yield |
---|---|
With potassium carbonate In ethyl acetate for 24h; Reflux; | 75.4% |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
2-{2-[1-(5-chlorothiophen-2-yl)-N-{4-[(5S)-5-{[(5-chlorothiophen-2-yl)formamido]methyl}-2-oxo-1,3-oxazolidin-3-yl]phenyl}formamido]ethoxy}acetic acid
Conditions | Yield |
---|---|
Stage #1: 2-{2-[1-(5-chlorothiophen-2-yl)-N-{4-[(5S)-5-{[(5-chlorothiophen-2-yl)formamido]methyl}-2-oxo-1,3-oxazolidin-3-yl]phenyl}formamido]ethoxy}acetic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 0 - 20℃; Cooling with ice; Stage #2: With triethylamine In N,N-dimethyl-formamide at 10 - 20℃; Stage #3: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride In N,N-dimethyl-formamide at 30 - 35℃; | 48.6% |
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 10h; Inert atmosphere; | 42.6% |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
bis(trichloromethyl) carbonate
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 4h; | 14% |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
bis(trichloromethyl) carbonate
N,N'-bis[{(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl]urea
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 20℃; | 13.1% |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
3-chlorothiophene-2-carbonyl chloride
Rivaroxaban
Conditions | Yield |
---|---|
Stage #1: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride With triethylamine In 1-methyl-pyrrolidin-2-one for 0.25h; Stage #2: 3-chlorothiophene-2-carbonyl chloride In 1-methyl-pyrrolidin-2-one at 10 - 82℃; |
methyl 5-chloro-2-thiophenecarboxylate
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Rivaroxaban
Conditions | Yield |
---|---|
at 120℃; for 48h; Product distribution / selectivity; Inert atmosphere; Heating; |
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