1027281-66-8

Basic information

• Product Name: 4-[4-(7-methyl-benzofuran-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester
• Synonyms: 4-[4-(7-methyl-benzofuran-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester
• CAS NO: 1027281-66-8
• Molecular Weight: 350.371
• Mol File: 1027281-66-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[4-(7-methyl-benzofuran-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(7-methyl-benzofuran-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester(1027281-66-8)
• EPA Substance Registry System: 4-[4-(7-methyl-benzofuran-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester(1027281-66-8)

Safety Data

• Hazardous Substances Data: 1027281-66-8(Hazardous Substances Data)

Upstream product

• 95-48-7 ortho-cresol 
• 117516-63-9 1-(2,2-diethoxyethoxy)-2-methylbenzene 
• 17059-52-8 7-methylbenzofuran 
• 57897-70-8 7-methyl-2-benzofurancarboxaldehyde 
• 187401-48-5 methyl 4-acryloyl-benzoate 

Downstream Products

• 1026278-52-3 4-[5-(7-methyl-benzofuran-2-yl)-1H-pyrrol-2-yl]-benzoic acid methyl ester 

Relevant articles and documents

Discovery of novel and potent retinoic acid receptor α agonists: Syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole derivatives

In the course of our studies on retinoic acid receptor (RAR) agonists, we have designed and synthesized a series of benzofuran and benzothiophene derivatives. Some of these compounds (1a,b,e,f,j) markedly inhibited LPS- induced B-lymphocyte proliferation and exerted RARα selectivity. One of them, 4-[5-(4,7-dimethylbenzofuran-2-yl)pyrrol-2-yl]benzoic acid (1b), when orally administered significantly inhibited mouse antibody production and delayed type hypersensitivity (DTH) responses from a dose of 0.1 mg/kg.