17059-52-8

Basic information

• Product Name: 7-methylbenzofuran
• Synonyms: Einecs 241-123-1;7-Methylbenzo[b]furan
• CAS NO: 17059-52-8
• Molecular Formula: C₉H₈O
• Molecular Weight: 132.1592
• EINECS: 241-123-1
• Mol File: 17059-52-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 109°C
• Boiling Point: 190.5°C (estimate)
• Flash Point: 71.4°C
• Appearance: /
• Density: 1.0490
• Vapor Pressure: 0.693mmHg at 25°C
• Refractive Index: 1.5525
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-methylbenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methylbenzofuran(17059-52-8)
• EPA Substance Registry System: 7-methylbenzofuran(17059-52-8)

Safety Data

• Hazardous Substances Data: 17059-52-8(Hazardous Substances Data)

Usage

Uses

7-Methylbenzofuran is an intermediate used to prepare mammalian target of rapamycin (mTOR) inhibitors.

InChI:InChI=1/C9H8O/c1-7-3-2-4-8-5-6-10-9(7)8/h2-6H,1H3

Upstream product

• 117516-63-9 1-(2,2-diethoxyethoxy)-2-methylbenzene 
• 95333-18-9 2-methylphenoxyacetaldehyde dimethyl acetal 
• 121045-21-4 6-<2-hydroxy-1-(isopropylthio)ethyl>-o-cresol 
• 95-48-7 ortho-cresol 
• 99179-39-2 (2-methylphenoxy)acetaldehyde 
• 6161-86-0 2-methylphenoxyethanol 
• 95-46-5 2-methylphenyl bromide 
• 110-00-9 furan 
• 534-22-5 2-methylfuran 

Downstream Products

• 57897-70-8 7-methyl-2-benzofurancarboxaldehyde 
• 1026278-52-3 4-[5-(7-methyl-benzofuran-2-yl)-1H-pyrrol-2-yl]-benzoic acid methyl ester 
• 1027281-66-8 4-[4-(7-methyl-benzofuran-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester 
• 90484-22-3 7-benzofuranylcarboxylic acid 
• 50543-55-0 7-methyl-2-phenylbenzofuran 

Relevant articles and documents

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Dioxazolones as masked ester surrogates in the Pd(ii)-catalyzed direct C-H arylation of 6,5-fused heterocycles

A simple and effective Pd(ii)-catalyzed regioselective C(2)-H arylation of 6,5-fused heterocycles with dioxazolones as a masked ester surrogate under mild conditions is reported. The significance of the arylation is highlighted by the new reactivity demonstrated in dioxazolones via proximal C-H activation of the cyclic carbonate of the hydroxamic acid functionality under protic conditions.

Palladium-Catalyzed Regioselective C-2 Arylation of Benzofurans with N′-Acyl Arylhydrazines

A novel ligand-free palladium-catalyzed C-2 arylation of benzofurans has been developed using N′-acyl arylhydrazines as the coupling partners and TEMPO as an oxidant. This protocol features a wide functional-group tolerance and highly regioselective products with good to excellent yields.

A Pincer Ruthenium Complex for Regioselective C-H Silylation of Heteroarenes

A pincer Ru(II) catalyst for the highly efficient undirected silylation of O- and S-heteroarenes with (TMSO)2MeSiH and Et3SiH is described, producing heteroarylsilanes with exclusive C2-regioselectivity, good functional-group tolerance, and high turnover numbers (up to 1960). The synthetic utility of the silylated products is demonstrated by Pd-catalyzed Hiyama-Denmark cross-coupling under mild conditions. One-pot, two-step silylation and coupling procedures have been also developed.