57897-70-8

Basic information

• Product Name: 2-Benzofurancarboxaldehyde, 7-methyl-
• Synonyms: 2-Benzofurancarboxaldehyde, 7-methyl-
• CAS NO: 57897-70-8
• Molecular Formula: C₁₀H₈O₂
• Molecular Weight: 160.17
• Mol File: 57897-70-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Benzofurancarboxaldehyde, 7-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzofurancarboxaldehyde, 7-methyl-(57897-70-8)
• EPA Substance Registry System: 2-Benzofurancarboxaldehyde, 7-methyl-(57897-70-8)

Safety Data

• Hazardous Substances Data: 57897-70-8(Hazardous Substances Data)

Usage

Primary use

synthetic intermediate in pharmaceuticals, fragrances, and organic compound production

Odor

aromatic and aldehydic
Commonly used in fragrance industry as scent additive
Used in manufacturing of antihistamines, antifungal agents, and other medicinal products
Studied for potential antibacterial and antifungal properties

Caution

should be handled with care and proper safety procedures to avoid health risks

Upstream product

• 179728-47-3 (2-formyl-6-methylphenoxy)acetaldehyde diethyl acetal 
• 17059-52-8 7-methylbenzofuran 
• 68-12-2 N,N-dimethyl-formamide 
• 117516-63-9 1-(2,2-diethoxyethoxy)-2-methylbenzene 
• 95-48-7 ortho-cresol 
• 824-42-0 2-methoxy-3-methylbenzaldehyde 
• 1188296-80-1 2-(1,2-dichloroethenyloxy)-1,3-dimethylbenzene 
• 53715-90-5 ethyl 7-methyl-1-benzofuran-2-carboxylate 

Downstream Products

• 1027281-66-8 4-[4-(7-methyl-benzofuran-2-yl)-4-oxo-butyryl]-benzoic acid methyl ester 
• 1026278-52-3 4-[5-(7-methyl-benzofuran-2-yl)-1H-pyrrol-2-yl]-benzoic acid methyl ester 

Relevant articles and documents

Efficient synthesis of chiral benzofuryl β-amino alcohols via a catalytic asymmetric Henry reaction

Chiral β-amino alcohol ligands were found effective for the copper(ii)-catalyzed asymmetric Henry reaction of benzofuran-2-carbaldehydes with nitromethane, which led to the formation of (S)-enriched benzofuryl β-nitro alcohols with satisfactory enantioselectivities (up to 98% ee). Using this catalytic protocol, bioactive (S)-benzofuryl β-amino alcohols could be conveniently prepared in short steps.

Discovery of novel and potent retinoic acid receptor α agonists: Syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole derivatives

In the course of our studies on retinoic acid receptor (RAR) agonists, we have designed and synthesized a series of benzofuran and benzothiophene derivatives. Some of these compounds (1a,b,e,f,j) markedly inhibited LPS- induced B-lymphocyte proliferation and exerted RARα selectivity. One of them, 4-[5-(4,7-dimethylbenzofuran-2-yl)pyrrol-2-yl]benzoic acid (1b), when orally administered significantly inhibited mouse antibody production and delayed type hypersensitivity (DTH) responses from a dose of 0.1 mg/kg.