1035219-96-5

Basic information

• Product Name: 2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE
• Synonyms: 2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE;2-brome-6,7-dihydrothiazole[5,4-C]pyridin-4(5H)-one;2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)
• CAS NO: 1035219-96-5
• Molecular Formula: C₆H₅BrN₂OS
• Molecular Weight: 233.0857
• Mol File: 1035219-96-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 487.675 °C at 760 mmHg
• Flash Point: 248.737 °C
• Appearance: /
• Density: 1.826 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.76±0.20(Predicted)
• CAS DataBase Reference: 2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE(1035219-96-5)
• EPA Substance Registry System: 2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE(1035219-96-5)

Safety Data

• Hazardous Substances Data: 1035219-96-5(Hazardous Substances Data)

Usage

General Description

2-BROMO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE is a chemical compound that belongs to the thiazolopyridine class of organic compounds. It is a brominated derivative of 6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one, which is a heteroaromatic organic compound. This chemical may have potential applications in the fields of medicinal chemistry and pharmaceuticals due to its unique structure and potential biological activities. There is ongoing research to explore its potential uses and properties in various fields.

Upstream product

• 845267-78-9 tert-butyl 2,4-dioxopiperidine-1-carboxylate 
• 1312412-87-5 tert-butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate 
• 1312412-88-6 tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate 
• 26493-11-8 2-amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 
• 1312412-89-7 2-amino-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one hydrochloride 

Downstream Products

• 1312414-28-0 5-methyl-2-phenoxymethyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 
• 1312412-58-0 2-phenylethynyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 
• 1312412-59-1 LuAF₃₂₁₀₅ 
• 1446715-63-4 C₁₄H₉FN₂OS 
• 1446715-64-5 C₁₄H₉ClN₂OS 
• 1446715-65-6 C₁₄H₉FN₂OS 
• 1446715-66-7 C₁₄H₉FN₂OS 
• 1446715-67-8 C₁₅H₁₂N₂O₂S 
• 1446715-68-9 C₁₅H₁₂N₂OS 
• 1312414-23-5 2-phenoxymethyl-5-(tetrahydropyran-4-ylmethyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 
• 1312414-65-5 2-phenoxymethyl-5-pyridin-2-yl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 
• 1312414-68-8 2-phenoxymethyl-5-pyridin-3-yl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 
• 1312414-69-9 2-phenoxymethyl-5-pyridin-4-yl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 
• 1312414-67-7 5-(5-fluoropyridin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 

Relevant articles and documents

FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators

A new series of potent fused thiazole mGlu5 receptor positive allosteric modulators (PAMs) (10, 11 and 27-31) are disclosed and details of the SAR and optimization are described. Optimization of alkynyl thiazole 9 (Lu AF11205) led to the identification of potent fused thiazole analogs 10b, 27a, 28j and 31d. In general, substituted cycloalkyl, aryl and heteroaryl carboxamides, and carbamate analogs are mGlu5 PAMs, whereas smaller alkyl carboxamide, sulfonamide and sulfamide analogs tend to be mGlu5 negative allosteric modulators (NAMs).

BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS

The present invention relates to novel bicyclic thiazoles of formula (I) which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ("mGluR5") and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.