1312412-88-6

Basic information

• Product Name: 2-AMino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester
• Synonyms: 2-AMino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester;tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
• CAS NO: 1312412-88-6
• Molecular Formula: C₁₁H₁₅N₃O₃S
• Molecular Weight: 269.3201
• EINECS: -0
• Mol File: 1312412-88-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester(1312412-88-6)
• EPA Substance Registry System: 2-AMino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester(1312412-88-6)

Safety Data

• Hazardous Substances Data: 1312412-88-6(Hazardous Substances Data)

Usage

General Description

2-Amino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C13H16N4O3S. It is a tert-butyl ester derivative of a thiazolo[5,4-c]pyridine-5-carboxylic acid, which is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. This chemical is known for its potential biological activities, including antimicrobial and antitumor properties. Its molecular structure and properties make it a valuable tool for researchers in the development of new drugs and therapeutic agents.

Upstream product

• 1312412-87-5 tert-butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate 
• 17356-08-0 thiourea 
• 845267-78-9 tert-butyl 2,4-dioxopiperidine-1-carboxylate 
• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1035219-96-5 2-bromo-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 
• 1312414-28-0 5-methyl-2-phenoxymethyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 
• 26493-11-8 2-amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 
• 1312412-58-0 2-phenylethynyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 
• 1312412-59-1 LuAF₃₂₁₀₅ 

Relevant articles and documents

FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor

Starting from a singleton chromanone high throughput screening (HTS) hit, we describe a focused medicinal chemistry optimization effort leading to the identification of a novel series of phenoxymethyl-dihydrothiazolopyridone derivatives as selective positive allosteric modulators (PAMs) of the metabotropic glutamate 5 (mGlu5) receptor. These dihydrothiazolopyridones potentiate receptor responses in recombinant systems. In vitro and in vivo drug metabolism and pharmacokinetic (DMPK) evaluation allowed us to select compound 16a for its assessment in a preclinical animal screen of possible antipsychotic activity. 16a was able to reverse amphetamine-induced hyperlocomotion in rats in a dose-dependent manner without showing any significant motor impairment or overt neurological side effects at comparable doses. Evolution of our medicinal chemistry program, structure activity, and properties relationships (SAR and SPR) analysis as well as a detailed profile for optimized mGlu5 receptor PAM 16a are described.

BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS

The present invention relates to novel bicyclic thiazoles of formula (I) which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ("mGluR5") and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.