1312412-58-0

Basic information

• Product Name: 2-phenylethynyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one
• Synonyms: 2-phenylethynyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one
• CAS NO: 1312412-58-0
• Molecular Weight: 254.312
• Mol File: 1312412-58-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-phenylethynyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylethynyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one(1312412-58-0)
• EPA Substance Registry System: 2-phenylethynyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one(1312412-58-0)

Safety Data

• Hazardous Substances Data: 1312412-58-0(Hazardous Substances Data)

Upstream product

• 26493-11-8 2-amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 
• 1312412-89-7 2-amino-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one hydrochloride 
• 1312412-88-6 tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate 
• 1312412-87-5 tert-butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate 
• 845267-78-9 tert-butyl 2,4-dioxopiperidine-1-carboxylate 
• 1035219-96-5 2-bromo-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 
• 536-74-3 phenylacetylene 

Downstream Products

• 1312412-59-1 LuAF₃₂₁₀₅ 
• 1312412-66-0 5-(2-methoxyethyl)-2-phenylethynyl-6,7-dihydro-5H-thiazolo-[5,4-c]pyridin-4-one 

Relevant articles and documents

Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators

A new series of potent fused thiazole mGlu5 receptor positive allosteric modulators (PAMs) (10, 11 and 27-31) are disclosed and details of the SAR and optimization are described. Optimization of alkynyl thiazole 9 (Lu AF11205) led to the identification of potent fused thiazole analogs 10b, 27a, 28j and 31d. In general, substituted cycloalkyl, aryl and heteroaryl carboxamides, and carbamate analogs are mGlu5 PAMs, whereas smaller alkyl carboxamide, sulfonamide and sulfamide analogs tend to be mGlu5 negative allosteric modulators (NAMs).

BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS

The present invention relates to novel bicyclic thiazoles which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”) and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.