112111-45-2 Usage
Description
(R)-(-)-Modafinil acid, also known as (R)-Modafinil, is an off-white solid with chemical properties that make it a valuable compound in the pharmaceutical industry. It is a derivative of Modafinil, a well-known stimulant medication used to promote wakefulness and treat various sleep disorders. The (R)-enantiomer of Modafinil has been found to possess specific therapeutic benefits, making it a promising candidate for medical applications.
Uses
Used in Pharmaceutical Industry:
(R)-(-)-Modafinil acid is used as an active pharmaceutical ingredient for the treatment of human or animal oligospermia and ovum-deficient diseases. It helps improve sperm count and quality in males and promotes the development and maturation of ova in females, addressing fertility issues in both sexes.
Additionally, due to its stimulant properties, (R)-(-)-Modafinil acid may also be used as a potential treatment for various sleep disorders, such as narcolepsy, sleep apnea, and shift work sleep disorder, as well as for cognitive enhancement in conditions like ADHD and other neurodegenerative diseases. However, further research and clinical trials are necessary to establish its efficacy and safety in these applications.
Check Digit Verification of cas no
The CAS Registry Mumber 112111-45-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,1,1 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 112111-45:
(8*1)+(7*1)+(6*2)+(5*1)+(4*1)+(3*1)+(2*4)+(1*5)=52
52 % 10 = 2
So 112111-45-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H14O3S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H,16,17)/t19-/m1/s1
112111-45-2Relevant articles and documents
Biocatalysts and methods for the synthesis of armodafinil
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Page/Page column 64-65, (2016/05/19)
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (?)-2-[(R)-(diphenyl-methyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
NOVEL CRYSTALLINE POLYMORPH OF ARMODAFINIL AND AN IMPROVED PROCESS FOR PREPARATION THEREOF
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Page/Page column 9, (2009/08/16)
The present invention relates to a novel crystalline polymorph of armodafinil. In another aspect the invention relates to an improved process for preparation of the novel polymorph of armodafinil.
A PROCESS OF SULFOXIDATION OF BIOLOGICALLY ACTIVE COMPOUNDS
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Page/Page column 13, (2009/01/24)
The present invention relates to a new process for the preparation of sulfoxides, preferably stereoselective preparation of substituted or unsubstituted chiral sulfinyl derivatives 2-(2- pyridylmethyl) sulfinyl-l H-benzimidazole by oxidation with oxaziridine in presence of suitable solvent and base.