1211515-30-8Relevant articles and documents
Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease
Grand, Darren Le,Gosling, Martin,Baettig, Urs,Bahra, Parmjit,Bala, Kamlesh,Brocklehurst, Cara,Budd, Emma,Butler, Rebecca,Cheung, Atwood K.,Choudhury, Hedaythul,Collingwood, Stephen P.,Cox, Brian,Danahay, Henry,Edwards, Lee,Everatt, Brian,Glaenzel, Ulrike,Glotin, Anne-Lise,Groot-Kormelink, Paul,Hall, Edward,Hatto, Julia,Howsham, Catherine,Hughes, Glyn,King, Anna,Koehler, Julia,Kulkarni, Swarupa,Lightfoot, Megan,Nicholls, Ian,Page, Christopher,Pergl-Wilson, Giles,Popa, Mariana Oana,Robinson, Richard,Rowlands, David,Sharp, Tom,Spendiff, Matthew,Stanley, Emily,Steward, Oliver,Taylor, Roger J.,Tranter, Pamela,Wagner, Trixie,Watson, Hazel,Williams, Gareth,Wright, Penny,Young, Alice,Sandham, David A.
, p. 7241 - 7260 (2021/06/28)
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel are established as the primary causative factor in the devastating lung disease cystic fibrosis (CF). More recently, cigarette smoke exposure has been shown to be asso
FUSED HETEROCYCLIC COMPOUND
-
Paragraph 0776, (2015/05/06)
The fused heterocyclic compound represented by formula (1) has excellent effectiveness in pest control. (In the formula, J represents formula J1, J2, J3, J4, J5 or J6; A1 represents a nitrogen atom, etc.; A2 represents a nitrogen atom, etc.; A3 represents a nitrogen atom, etc.; A4 represents a nitrogen atom, etc.; A5 represents a nitrogen atom, etc.; B1 represents a nitrogen atom, etc.; B2 represents a nitrogen atom, etc.; B3 represents NR15, etc.; B4 represents a nitrogen atom, etc.; B5 represents a nitrogen atom, etc.; B6 represents a nitrogen atom, etc.; R1 represents a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; R2 and R3 are the same or different, and represent a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; R4 represents a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group W; R5 and R6 are the same or different, and represent a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; and n represents 0, 1,2).
