124486-72-2

Basic information

• Product Name: (+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol
• Synonyms: (+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol
• CAS NO: 124486-72-2
• Molecular Weight: 249.718
• Mol File: 124486-72-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol(124486-72-2)
• EPA Substance Registry System: (+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol(124486-72-2)

Safety Data

• Hazardous Substances Data: 124486-72-2(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 1197-22-4 N-phenylmethanesulfonamide 
• 64488-52-4 N-[4-(2-chloro-1-oxoethyl)phenyl]methanesulfonamide 

Downstream Products

• 187831-22-7 2-chloro-1-(4'-methanesulfonamidophenyl)ethanol 
• 157023-58-0 2-chloro-1-(4'-methanesulfonamidophenyl)ethanol 

Relevant articles and documents

Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol

Synthesis of both enantiomers of biologically active propranolol and sotalol has been achieved in high optical purity by one-pot reduction of 3 and 7 followed by in situ lipase resolution of the respective chlorohydrins. Pseudomonas cepacia lipase immobilized on ceramic particles (PS-C) provided the chlorohydrin and acetate, which on nucleophilic substitution with isopropyl amine afforded the target amino alcohols in high enantioselectivity under mild reaction conditions.