64488-52-4

Basic information

• Product Name: N-[4-(2-CHLOROACETYL)PHENYL]METHANESULFONAMIDE
• Synonyms: 4CAMS;4-(2-CHLORACETYL) METHANE SULFONANILIDE;4-(2-CHLOROACETYL)-METHANESULFONANILIDE;N-[4-(2-CHLOROACETYL)PHENYL]METHANESULFONAMIDE;4-(2-Chloroacetyl)Methanesulfon Anilide 64488-52-4;4-(2-CHLORACETYL) METHANE SULFONANILIDE(INTERMEDIATE OF SOTALOL HYDROCHLORIDE);4-(Chloroacetyl)-Methylsulphonanilide;n-(4-Chloroacetylphenyl)methanesulfonamide , 98% (uv-vis)
• CAS NO: 64488-52-4
• Molecular Formula: C₉H₁₀ClNO₃S
• Molecular Weight: 247.7
• Mol File: 64488-52-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 197.5-199.0 °C
• Boiling Point: 410.4 °C at 760 mmHg
• Flash Point: 202 °C
• Appearance: /
• Density: 1.433 g/cm³
• Vapor Pressure: 6.06E-07mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.94±0.10(Predicted)
• CAS DataBase Reference: N-[4-(2-CHLOROACETYL)PHENYL]METHANESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(2-CHLOROACETYL)PHENYL]METHANESULFONAMIDE(64488-52-4)
• EPA Substance Registry System: N-[4-(2-CHLOROACETYL)PHENYL]METHANESULFONAMIDE(64488-52-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 64488-52-4(Hazardous Substances Data)

Usage

Uses

N-[4-(2-Chloroacetyl)phenyl]methanesulfonamide, is a building block used in the synthesis of various compounds.

InChI:InChI=1/C9H10ClNO3S/c1-15(13,14)11-8-4-2-7(3-5-8)9(12)6-10/h2-5,11H,6H2,1H3

Upstream product

• 1197-22-4 N-phenylmethanesulfonamide 
• 79-04-9 chloroacetyl chloride 
• 62-53-3 aniline 

Downstream Products

• 110698-54-9 3-(2-{4-[(metylsulfonyl)amino]phenyl}-2-oxoethyl)thiazolium chloride 
• 110698-57-2 N-{4-[2-(4,5-dihydro-2-methyl-1H-imidazol-1-yl)-1-oxoethyl]phenyl}methanesulfonamide 
• 97163-47-8 3-methyl-1-<2-<4-<(methylsulfonyl)amino>phenyl>-2-oxoethyl>-1H-imidazolium chloride 
• 107053-33-8 3-Ethyl-1-[2-(4-methanesulfonylamino-phenyl)-2-oxo-ethyl]-3H-imidazol-1-ium; chloride 
• 107037-51-4 1-[2-(4-Methanesulfonylamino-phenyl)-2-oxo-ethyl]-2,3-dimethyl-3H-imidazol-1-ium; chloride 
• 107037-52-5 1-[2-(4-Methanesulfonylamino-phenyl)-2-oxo-ethyl]-2,3,4,5-tetramethyl-3H-imidazol-1-ium; chloride 
• 107037-50-3 3-Isopropyl-1-[2-(4-methanesulfonylamino-phenyl)-2-oxo-ethyl]-3H-imidazol-1-ium; chloride 
• 187831-22-7 2-chloro-1-(4'-methanesulfonamidophenyl)ethanol 
• 157023-58-0 2-chloro-1-(4'-methanesulfonamidophenyl)ethanol 
• 124486-72-2 (+)-2-chloro-1-(4'-N-mesylaminophenyl)ethanol 
• 107037-61-6 1-[2-Hydroxy-2-(4-methanesulfonylamino-phenyl)-ethyl]-2,3-dimethyl-3H-imidazol-1-ium; chloride 
• 107037-57-0 3-Ethyl-1-[2-hydroxy-2-(4-methanesulfonylamino-phenyl)-ethyl]-3H-imidazol-1-ium; chloride 
• 107037-58-1 1-[2-Hydroxy-2-(4-methanesulfonylamino-phenyl)-ethyl]-3-isopropyl-3H-imidazol-1-ium; chloride 
• 107037-62-7 1-[2-Hydroxy-2-(4-methanesulfonylamino-phenyl)-ethyl]-2,3,4,5-tetramethyl-3H-imidazol-1-ium; chloride 

Relevant articles and documents

Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol

Synthesis of both enantiomers of biologically active propranolol and sotalol has been achieved in high optical purity by one-pot reduction of 3 and 7 followed by in situ lipase resolution of the respective chlorohydrins. Pseudomonas cepacia lipase immobilized on ceramic particles (PS-C) provided the chlorohydrin and acetate, which on nucleophilic substitution with isopropyl amine afforded the target amino alcohols in high enantioselectivity under mild reaction conditions.

Synthesis and Antiarrhythmic Activity of Novel 3-Alkyl-1-phenyl>-ω-hydroxyalkyl>-1H-imidazolium Salts and Related Compounds

Novel 3-alkyl-1-phenyl>-ω-hydroxyalkyl>-1H-imidazolium salts were synthesized and investigated for their class III electrophysiological activity on isolated canine cardiac Purkinje fibers and ventricular muscle tissue.Structure-activity relationships are discussed for a series of 25 compounds.Compound 3, 1-phenyl>ethyl>-3-methyl-1H-imidazolium chloride, prolonged the functional refractory period in anesthetized dogs when given intraduodenally and was also effective in preventing reentrant ventricular tachycardia induced by programmed electrical stimulation when administered intravenously in anesthetized dogs 24 h after an acute myocardial infarction.Both enantiomers of 3 were synthesized.No enantioselectivity was found in the electrophysiological effects of 3.