1276113-16-6

Basic information

• Product Name: 4,5-dimethoxy-2-trimethylsilylphenol
• Synonyms: 4,5-dimethoxy-2-trimethylsilylphenol
• CAS NO: 1276113-16-6
• Molecular Weight: 226.348
• Mol File: 1276113-16-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4,5-dimethoxy-2-trimethylsilylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dimethoxy-2-trimethylsilylphenol(1276113-16-6)
• EPA Substance Registry System: 4,5-dimethoxy-2-trimethylsilylphenol(1276113-16-6)

Safety Data

• Hazardous Substances Data: 1276113-16-6(Hazardous Substances Data)

Upstream product

• 2104695-66-9 C₁₁H₁₇BrO₃Si 
• 129103-69-1 2-bromo-4,5-dimethoxyphenol 
• 521067-39-0 2-bromo-1-tert-butyldimethylsilyloxy-4,5-dimethoxybenzene 
• 4039-32-1 lithium hexamethyldisilazane 
• 2033-89-8 3,4-dimethoxyphenol 

Downstream Products

• 866252-52-0 4,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 1582787-69-6 4,5-dimethoxy-2-(trimethylsilyl)phenyl nonaflate 
• 2033-89-8 3,4-dimethoxyphenol 
• 398-62-9 4-fluoroveratrole 

Relevant articles and documents

Trifluoromethyl aryl sulfonates (TFMS): An applicable trifluoromethoxylation reagent

Fluorine is probably another favorite hetero-atom for incorporation into small molecules after nitrogen. Among many fluorine-containing groups, trifluoromethyl aryl ethers (ArOCF3) have unique properties in drug design and are difficult to be synthesized, and many different methods were developed to prepare them. A novel one-pot synthesis of o-iodine-aryl trifluoromethyl ethers (ArOCF3I) was described by the reaction of trifluoromethoxylation and iodination with trifluoromethyl aryl sulfonates (TFMS) in this manuscript. The reaction conditions were optimized by screening different solvents, crown ethers, substrates and the ratios and the yields of products were in moderate to high yields (up to 86%).