398-62-9

Basic information

• Product Name: 1,2-DIMETHOXY-4-FLUOROBENZENE
• Synonyms: 4-FLUORO-1,2-DIMETHOXYBENZENE;3,4-DIMETHOXY-1-FLUOROBENZENE;3,4-DIMETHOXYFLUOROBENZENE;1-FLUORO-3,4-DIMETHOXYBENZENE;1,2-DIMETHOXY-4-FLUOROBENZENE;4-Fluoroveratrole,98%;1,2-Dimethoxy-4-fluorobenzene 98%;1,2-Dimethoxy-4-fluorobenzene98%
• CAS NO: 398-62-9
• Molecular Formula: C₈H₉FO₂
• Molecular Weight: 156.15
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Fluorine series
• Mol File: 398-62-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 120-123°C 45mm
• Flash Point: 197 °F
• Appearance: white to light yellow crystal
• Density: 1.171 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.51(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Water Solubility: Soluble in water 0.079 g/L 25°C.
• BRN: 2441600
• CAS DataBase Reference: 1,2-DIMETHOXY-4-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIMETHOXY-4-FLUOROBENZENE(398-62-9)
• EPA Substance Registry System: 1,2-DIMETHOXY-4-FLUOROBENZENE(398-62-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 398-62-9(Hazardous Substances Data)

Usage

Description

1,2-DIMETHOXY-4-FLUOROBENZENE is an organic compound characterized by its white to light yellow crystalline appearance. It is a derivative of benzene with a fluorine atom at the 4-position and two methoxy groups at the 1 and 2 positions. 1,2-DIMETHOXY-4-FLUOROBENZENE is known for its stability and reactivity, making it a versatile building block in organic synthesis.

Uses

Used in Organic Synthesis:
1,2-DIMETHOXY-4-FLUOROBENZENE is used as a raw material for the synthesis of various organic compounds. Its unique structure allows for a wide range of chemical reactions, making it a valuable intermediate in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,2-DIMETHOXY-4-FLUOROBENZENE is used as a key intermediate in the synthesis of various drug molecules. Its presence in the molecular structure can influence the biological activity and pharmacokinetic properties of the final drug product, making it an essential component in drug discovery and development.
Used in Agrochemical Industry:
1,2-DIMETHOXY-4-FLUOROBENZENE is also utilized in the agrochemical industry for the synthesis of active ingredients in pesticides and other crop protection products. Its incorporation into these molecules can enhance their efficacy, selectivity, and environmental compatibility.
Used in Chemical Research:
In the field of chemical research, 1,2-DIMETHOXY-4-FLUOROBENZENE serves as a model compound for studying various reaction mechanisms and exploring new synthetic methodologies. Its unique reactivity and stability make it an ideal candidate for testing new catalysts, reagents, and reaction conditions.

Upstream product

• 67-56-1 methanol 
• 452-64-2 3,4-dimethyl-fluorobenzene 
• 6315-89-5 3,4-dimethoxyaniline 
• 2859-78-1 4-Bromoveratrole 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 1582787-69-6 4,5-dimethoxy-2-(trimethylsilyl)phenyl nonaflate 
• 1582787-70-9 2-(t-butyldimethylsilyl)-4,5-dimethoxyphenyl nonaflate 
• 1276113-16-6 4,5-dimethoxy-2-trimethylsilylphenol 
• 1582787-64-1 C₁₄H₂₄O₃Si 
• 866252-52-0 4,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 2033-89-8 3,4-dimethoxyphenol 
• 1583285-88-4 3-(3,4-dimethoxyphenyl)-1,1,1,3,5,5,5-heptamethyltrisiloxane 

Downstream Products

• 367-32-8 4-fluoropyrocatechol 
• 91407-48-6 2-(chloromethyl)-4,5-dimethoxy-1-fluorobenzene 
• 71924-62-4 2-fluoro-4,5-dimethoxybenzaldehyde 
• 142265-69-8 1-(2-fluoro-4,5-dimethoxyphenyl)ethanone 
• 457628-14-7 6-fluoro-2,3-dimethoxybenzaldehyde 
• 265670-72-2 6-fluoro-2,3-dimethoxybenzoic acid 
• 23023-16-7 2‐(3,4‐dimethoxyphenyl)‐2‐methylpropionitrile 
• 91407-49-7 2-(2-fluoro-4,5-dimethoxyphenyl)acetonitrile 
• 492444-04-9 5-fluoro-1,3-benzodioxol-4-amine 
• 492444-05-0 6-fluoro-2,3-dihydroxybenzoic acid 
• 492444-06-1 methyl 6-fluoro-2,3-dihydroxybenzoate 
• 492444-08-3 5-fluoro-1,3-benzodioxole-4-carboxylic acid 
• 492444-09-4 tert-butyl (5-fluoro-1,3-benzodioxol-4-yl)carbamate 
• 1026401-56-8 6-fluoro-2,3-dimethoxy-benzoyl chloride 

Relevant articles and documents

An improved synthesis of 4-fluoroveratrole. Efficient route to 6-fluoroveratraldehyde and 6-fluoro-D,L-DOPA

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Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination

Photoredox catalysis, especially in combination with transition metal catalysis, can produce redox states of transition metal catalysts to facilitate challenging bond formations that are not readily accessible in conventional redox catalysis. For arene functionalization, metallophotoredox catalysis has successfully made use of the same leaving groups as those valuable in conventional cross-coupling catalysis, such as bromide. Yet the redox potentials of common photoredox catalysts are not sufficient to reduce most aryl bromides, so synthetically useful aryl radicals are often not directly available. Therefore, the development of a distinct leaving group more appropriately matched in redox potential could enable new reactivity manifolds for metallophotoredox catalysis, especially if arylcopper(iii) complexes are accessible, from which the most challenging bond-forming reactions can occur. Here we show the conceptual advantages of aryl thianthrenium salts for metallophotoredox catalysis, and their utility in site-selective late-stage aromatic fluorination.

Application of trivalent iodine compounds as catalysts in Bal-Schiemann reaction

The invention discloses an application of trivalent iodine compounds shown in formula I and/or II in the description and used as catalysts in Bal-Schiemann reaction. The trivalent iodine compounds areused as the catalysts in the Bal-Schiemann reaction, so that the Bal-Schiemann reaction can be conducted at room temperature or near room temperature when a thermochemical method is used, and the reaction has mild reaction conditions, wide substrate use range and short reaction time, and is safe and easy to operate, products are easy to separate, and raw materials are simple and low in toxicity.