133467-01-3

Basic information

• Product Name: BOC-D-LEUCINE METHYL ESTER
• Synonyms: BOC-D-LEUCINE METHYL ESTER;BOC-D-LEU-OME;N-ALPHA-T-BUTOXYCARBONYL-D-LEUCINE METHYL ESTER
• CAS NO: 133467-01-3
• Molecular Formula: C₁₂H₂₃NO₄
• Molecular Weight: 245.317
• Mol File: 133467-01-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 322.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.008±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.21±0.46(Predicted)
• CAS DataBase Reference: BOC-D-LEUCINE METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-LEUCINE METHYL ESTER(133467-01-3)
• EPA Substance Registry System: BOC-D-LEUCINE METHYL ESTER(133467-01-3)

Safety Data

• Hazardous Substances Data: 133467-01-3(Hazardous Substances Data)

Usage

General Description

BOC-D-leucine methyl ester is a chemical compound used in research and development. It is a derivative of leucine, an essential amino acid found in proteins. The compound is often used in the synthesis of peptides and proteins, as well as in drug discovery and medicinal chemistry. BOC-D-leucine methyl ester is commonly employed as a building block in the creation of molecular structures for various applications, such as in the study of enzymatic reactions, drug delivery systems, and biomolecular interactions. Its unique properties and reactivity make it a valuable tool in the field of organic chemistry and biochemistry.

Upstream product

• 186581-53-3 diazomethane 
• 16937-99-8 N-Boc-D-Leu 
• 74-88-4 methyl iodide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 35799-87-2 methyl (R)-2-(N-acetylamino)-4-methylpentanoate 
• 69805-63-6 methyl 2-((tert-butoxycarbonyl)amino)-4-methylpentanoate 
• 150566-46-4 (S)-1-((2R,5R)-2,5-Bis-methoxymethyl-pyrrolidin-1-yl)-2-iodo-4-methyl-pent-4-en-1-one 
• 150566-50-0 [(R)-1-((2R,5R)-2,5-Bis-methoxymethyl-pyrrolidine-1-carbonyl)-3-methyl-but-3-enyl]-carbamic acid tert-butyl ester 
• 63096-25-3 Boc-α,β-Dehydroleucin-methylester 
• 23032-21-5 D-leucine methyl ester 
• 2666-93-5 (S)-Leu-OMe 
• 5845-53-4 (R)-leucine methyl ester hydrochloride 

Downstream Products

• 106930-51-2 tert-butyl [(2R)-1-hydroxy-4-methylpentan-2-yl]carbamate 
• 116662-96-5 (2R)-2-(1,1-dimethylethoxycarbonylamino)-4-methylpentanal 
• 354588-76-4 3-({1-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyl]-but-3-enyloxy}-dimethylsilanyloxy)-2-isobutyl-pent-4-enethioic acid S-benzyl ester 
• 354588-74-2 3-({1-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyl]-but-3-enyloxy}-dimethylsilanyloxy)-2-isobutyl-pent-4-enethioic acid S-benzyl ester 
• 354588-73-1 3-({1-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyl]-but-3-enyloxy}-dimethylsilanyloxy)-2-isobutyl-pent-4-enethioic acid S-benzyl ester 
• 354588-75-3 3-({1-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyl]-but-3-enyloxy}-dimethylsilanyloxy)-2-isobutyl-pent-4-enethioic acid S-benzyl ester 
• 354588-69-5 3-({1-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyl]-but-3-enyloxy}-dimethylsilanyloxy)-2-isobutyl-pent-4-enethioic acid S-benzyl ester 

Relevant articles and documents

N-1 BRANCHED ALKYL SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS

Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing (or inhibiting) cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.

A simple, rapid, and efficient N-Boc protection of amines under ultrasound irradiation and catalyst-free conditions

A green and simple approach for the N-Boc protection on structurally diverse amines under ultrasound irradiation is described. Selective N-Boc protection was achieved in excellent isolated yield in a short reaction time at room temperature. Mild conditions, inexpensive and an easily available reagent, and absence of any auxiliary substances are the main advantages of this procedure. Graphical abstract: [Figure not available: see fulltext.]

Highly modular P-OP ligands for asymmetric hydrogenation: Synthesis, catalytic activity, and mechanism

A library of enantiomerically pure P-OP ligands (phosphine-phosphite), straightforwardly available in two synthetic steps from enantiopure Sharpless epoxy ethers is reported. Both the alkyloxy and phosphite groups can be optimized for maximum enantioselectivity and catalytic activity. Their excellent performance in the Rhcatalyzed asymmetric hydrogenation of a wide variety of functionalized alkenes (26 examples) and modular design makes them attractive for future applications. The lead catalyst incorporates an (S)-BINOL-derived (BINOL= 1,1'bi-2-naphthol) phosphite group with computational studies revealing that this moiety has a dual effect on the behavior of our P-OP ligands. On one hand, the electronic properties of phosphite hinder the binding and reaction of the substrate in two out of the four possible manifolds. On the other hand, the steric effects of the BINOL allow for discrimination between the two remaining manifolds, thereby elucidating the high efficiency of these catalysts.