1345413-22-0

Basic information

• Product Name: 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one
• Synonyms: 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one
• CAS NO: 1345413-22-0
• Molecular Weight: 215.156
• Mol File: 1345413-22-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one(1345413-22-0)
• EPA Substance Registry System: 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one(1345413-22-0)

Safety Data

• Hazardous Substances Data: 1345413-22-0(Hazardous Substances Data)

Upstream product

• 367-11-3 ortho-difluorobenzene 
• 625-36-5 2-chloropropionyl chloride 
• 1215969-79-1 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one 

Downstream Products

• 1006614-49-8 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine 
• 376608-71-8 trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (2R)-2-hydroxy-2-phenylacetic acid salt 
• 1345413-23-1 (1R)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol 
• 1345413-20-8 trans-(1S,2R)-2-(3,4-difluorophenyl)-cyclopropylamine 
• 1345413-25-3 (1S)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol 
• 1345413-26-4 trans-(1R,2S)-2-(3,4-difluorophenyl)-1-nitrocyclopropane 
• 274693-27-5 ticagrelor 
• 1383715-62-5 2-({(3aR,4S,6R,6aS)-6-[7-{[[N-(IR,2S)-2-(3,4-difluorophenyl)-cyclopropan-1-yl]-N-benzyl]amino}-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl}oxy)ethanol 
• 1383715-63-6 C₃₀H₃₄F₂N₆O₄S 
• 1383715-64-7 2-({(3aR,45,6R,6aS)-6-[7-{[[N-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropan-1-yl]-N-tert-butoxycarbonyl]amino}-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl}oxy)-O-tertbutoxycarbonylethanol 
• 1432581-76-4 rac-1-(3,4-difluorophenyl)-3-nitropropan-1-ol 
• 1432581-77-5 4-(1-bromo-3-nitropropyl)-1,2-difluorobenzene 
• 1006614-49-8 2-(3,4-difluorophenyl)cyclopropanamine 
• 1345413-24-2 trans-(1S,2R)-2-(3,4-difluorophenyl)-1-nitrocyclopropane 

Relevant articles and documents

Copper-Catalyzed Asymmetric Hydrosilylation of β-Nitroethyl Aryl Ketones

A copper-catalyzed asymmetric hydrosilylation of β-nitroethyl aryl ketones has been disclosed, and the corresponding chiral alcohols could be obtained in high yields (up to 99% yield) and excellent enantioselectivities (up to 96% ee). Moreover, the reaction worked well on a gram scale with 0.3 mol % of ligand loading, indicating that our protocol has potential applications in the synthesis of important pharmaceuticals such as Tranylcypromine and Ticagrelor.

NOVEL PROCESS FOR PREPARING PHENYLCYCLOPROPYLAMINE DERIVATIVES USING NOVEL INTERMEDIATES

Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.

NOVEL PROCESSES FOR PREPARING TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF

Provided herein is a novel process for the preparation of triazolo[4,5-d]pyrimidine derivatives. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of highly pure ticagrelor or a pharmaceutically acceptable salt thereof. Provided further herein is a novel process for the preparation of substituted cyclopentanamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a ticagrelor intermediate, 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d] [1,3]- dioxol-4-yl]oxy]- 1 -ethanol.