1345413-25-3

Basic information

• Product Name: (1S)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol
• Synonyms: (1S)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol
• CAS NO: 1345413-25-3
• Molecular Weight: 217.172
• Mol File: 1345413-25-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (1S)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol(1345413-25-3)
• EPA Substance Registry System: (1S)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol(1345413-25-3)

Safety Data

• Hazardous Substances Data: 1345413-25-3(Hazardous Substances Data)

Usage

Description

(1S)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol is a chiral chemical compound with the molecular formula C9H9F2NO3. It features a 1-hydroxy-3-nitropropane moiety and a 3,4-difluorophenyl group attached to the chiral carbon atom, giving it unique structural properties.

Uses

Used in Pharmaceutical Industry:
(1S)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol is used as a building block in organic synthesis for the preparation of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, (1S)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol serves as a crucial intermediate in the synthesis of different agrochemicals, contributing to the creation of effective products for agricultural applications.
Used in Research and Development:
(1S)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol is also utilized in research for its potential biological activity and pharmacological properties, as scientists explore its capabilities in treating various conditions and furthering medical knowledge.

Upstream product

• 369-33-5 3',4'-difluoroacetophenone 
• 1345413-22-0 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one 
• 1215969-79-1 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one 
• 367-11-3 ortho-difluorobenzene 

Downstream Products

• 1006614-49-8 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine 
• 1345413-26-4 trans-(1R,2S)-2-(3,4-difluorophenyl)-1-nitrocyclopropane 
• 1006614-49-8 2-(3,4-difluorophenyl)cyclopropanamine 
• 1432581-77-5 4-(1-bromo-3-nitropropyl)-1,2-difluorobenzene 
• 1383715-64-7 2-({(3aR,45,6R,6aS)-6-[7-{[[N-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropan-1-yl]-N-tert-butoxycarbonyl]amino}-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl}oxy)-O-tertbutoxycarbonylethanol 
• 1383715-63-6 C₃₀H₃₄F₂N₆O₄S 
• 1383715-62-5 2-({(3aR,4S,6R,6aS)-6-[7-{[[N-(IR,2S)-2-(3,4-difluorophenyl)-cyclopropan-1-yl]-N-benzyl]amino}-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl}oxy)ethanol 
• 1383715-61-4 tert-butyl N-[3-[(3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyl-hexahydrocyclopenta[d][1,3]dioxol-4-yl]-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]carbamate 
• 1383715-60-3 2-[[(3aR,4S,6R,6aS)-6-[[4-[N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-yl]-N-tert-butoxycarbonyl]amino]-2-(propylthio)-5-aminopyrimidin-6-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy]ethanol 
• 1383715-59-0 2-[[(3aR,4S,6R,6aS)-6-[[4-[N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-yl]-N-tert-butoxycarbonyl]amino]-2-(propylthio)-5-nitropyrimidin-6-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy] ethanol 
• 1383715-58-9 tert-butyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate 
• 1350749-64-2 tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate 
• 274693-27-5 ticagrelor 
• 274693-26-4 [3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol 

Relevant articles and documents

Copper-Catalyzed Asymmetric Hydrosilylation of β-Nitroethyl Aryl Ketones

A copper-catalyzed asymmetric hydrosilylation of β-nitroethyl aryl ketones has been disclosed, and the corresponding chiral alcohols could be obtained in high yields (up to 99% yield) and excellent enantioselectivities (up to 96% ee). Moreover, the reaction worked well on a gram scale with 0.3 mol % of ligand loading, indicating that our protocol has potential applications in the synthesis of important pharmaceuticals such as Tranylcypromine and Ticagrelor.

Highly enantioselective bioreduction of 1-(3,4-difluorophenyl)-3-nitropropan-1-one: Key intermediate of ticagrelor

A simple, highly effective and economical whole-cell mediated process was developed for the biocatalytic reduction of a ketone, intermediate in the synthesis of platelet inhibiting drug ticagrelor. Sixteen different microorganisms were screened for the bi

NOVEL PROCESS FOR PREPARING PHENYLCYCLOPROPYLAMINE DERIVATIVES USING NOVEL INTERMEDIATES

Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.