137320-89-9

Basic information

• Product Name: Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-(2-phenylethyl)-8-(phenylmethyl)-
• CAS NO: 137320-89-9
• Molecular Formula: C27H23N3O2
• Molecular Weight: 421.499
• Mol File: 137320-89-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-(2-phenylethyl)-8-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-(2-phenylethyl)-8-(phenylmethyl)-(137320-89-9)
• EPA Substance Registry System: Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-(2-phenylethyl)-8-(phenylmethyl)-(137320-89-9)

Safety Data

• Hazardous Substances Data: 137320-89-9(Hazardous Substances Data)

Upstream product

• 123437-73-0 3-benzyl-5-(4-methoxy-phenyl)-1-oxy-pyrazin-2-ylamine 
• 40040-81-1 2-amino-3-benzyl-5-(4-methoxyphenyl)-pyrazine 
• 103-63-9 1-phenyl-2-bromoethane 
• 55379-75-4 2-amino-3-phenylpropanenitrile 
• 96952-94-2 1,1-diethoxy-4-phenylbutan-2-one 
• 1823-76-3 p-methoxy-isonitrosoacetophenone 
• 56485-07-5 phenyl-1,2-butanedione 
• 37156-84-6 4-(5-amino-6-benzyl-pyrazin-2-yl)-phenol 

Relevant articles and documents

Chemi- and Bio-luminescence of Coelenterazine Analogues with Phenyl Homologues at the C-2 Position

A series of phenyl homologues of coelenterazine substituted at the C-2 position were synthesized and their bio- and chemi-luminescence properties were investigated including the measurement of chemiluminescence spectra in various media.The light emitting species of each analogue was found to be a neutral form of a coelenteramide derivative in diethylene glycol dimethyl ether (DGM) containing a trace amount of acetate buffer (pH 5.60), while a monoanion was found only in dimethyl sulfoxide (DMSO) and a dianion was observed in DMSO containing a trace amount of aqueous sodium hydroxide.Based on pseudo first-order reaction kinetics, chemiluminescence rate constants were obtained in DGM containing a trace amount of acetate buffer.Each of the synthetic coelenterazine analogues was incorporated into recombinant apoaequorin to obtain a series of semisynthetic aequorins.Measurements of bioluminescence activities of the aequorins revealed that a benzyl group in the C-2 position was essential for efficient luminescence activity.A two-step incubation procedure was used to determine why some analogues gave less luminescence activity than the benzyl analogue and natural coelenterazine.