37156-84-6

Basic information

• Product Name: 4-(5-amino-6-benzylpyrazin-2-yl)phenol
• Synonyms: 4-(5-amino-6-benzylpyrazin-2-yl)phenol;4-(5-amino-6-benzyl-1H-pyrazin-2-ylidene)cyclohexa-2,5-dien-1-one
• CAS NO: 37156-84-6
• Molecular Formula: C₁₇H₁₅N₃O
• Molecular Weight: 277.3205
• Mol File: 37156-84-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 201.6-203.1 °C
• Boiling Point: 446.9°Cat760mmHg
• Flash Point: 224.1°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 3.5E-08mmHg at 25°C
• Refractive Index: 1.653
• PKA: 8.46±0.15(Predicted)
• CAS DataBase Reference: 4-(5-amino-6-benzylpyrazin-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-amino-6-benzylpyrazin-2-yl)phenol(37156-84-6)
• EPA Substance Registry System: 4-(5-amino-6-benzylpyrazin-2-yl)phenol(37156-84-6)

Safety Data

• Hazardous Substances Data: 37156-84-6(Hazardous Substances Data)

Usage

General Description

4-(5-amino-6-benzylpyrazin-2-yl)phenol is a chemical compound with the molecular formula C17H15N3O. It belongs to the class of phenols and is derived from pyrazine and phenol. It is a white crystalline powder and has a molecular weight of 277.32 g/mol. 4-(5-amino-6-benzylpyrazin-2-yl)phenol is used in pharmaceutical research and has shown potential for treating certain medical conditions. Its unique structure and properties make it a valuable component in the development of new drugs and therapeutic treatments. However, further research and testing are needed to fully understand its potential benefits and applications.

InChI:InChI=1/C17H15N3O/c18-17-15(10-12-4-2-1-3-5-12)20-16(11-19-17)13-6-8-14(21)9-7-13/h1-9,11,20H,10,18H2

Upstream product

• 40040-81-1 2-amino-3-benzyl-5-(4-methoxyphenyl)-pyrazine 
• 187961-92-8 (3-amino-6-(4-hydroxyphenyl)pyrazin-2-yl)(phenyl)methanone 
• 109-89-7 diethylamine 
• 264608-76-6 2-(p-azidophenyl)-8-benzyl-6-(p-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one 
• 93554-83-7 α-aminophenylpropiononitrile hydrochloride 
• 22288-50-2 (E)-4-hydroxy-1'-oxo-benzeneacetaldehyde aldoxime 
• 108-88-3 toluene 
• 174680-55-8 2-amino-5-bromo-3-phenylmethylpyrazine 
• 185148-51-0 3-benzyl-2-pyrazinamine 
• 1823-76-3 p-methoxy-isonitrosoacetophenone 
• 55379-75-4 2-amino-3-phenylpropanenitrile 
• 123437-73-0 3-benzyl-5-(4-methoxy-phenyl)-1-oxy-pyrazin-2-ylamine 
• 55779-48-1 coelenterazine 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 

Downstream Products

• 141380-55-4 8-Benzyl-2-tert-butyl-6-(4-hydroxy-phenyl)-7H-imidazo[1,2-a]pyrazin-3-one 
• 137320-88-8 8-benzyl-6-hydroxyphenyl-2-phenylimidazo<1,2-a>pyrazin-3-one 
• 50909-86-9 2,8-dibenzyl-6-(4-hydroxyphenyl)imidazo[1,20-a]pyrazin-3(7H)one 
• 137320-89-9 8-benzyl-6-hydroxyphenyl-2-(2-phenylethyl)imidazo<1,2-a>pyrazin-3-one 
• 74637-92-6 (Z)-2-[3-Benzyl-5-(4-hydroxy-phenyl)-pyrazin-2-ylamino]-3-(4-hydroxy-phenyl)-acrylic acid 
• 62541-09-7 Watasenia dehydropreluciferin 
• 55779-48-1 coelenterazine 
• 141362-35-8 2-[(Z)-3-Benzyl-5-(4-hydroxy-phenyl)-pyrazin-2-ylimino]-3,3-dimethyl-butyric acid 2-trimethylsilanyl-ethyl ester 
• 137320-90-2 8-benzyl-6-hydroxyphenyl-2-(3-phenylpropyl)imidazo<1,2-a>pyrazin-3-one 
• 148058-41-7 3-benzyl-5-(4-hydroxyphenyl)-2-<4-(1-azi-2,2,2-trifluoroethyl)phenylacetamido>pyrazine 
• 168292-84-0 8-benzyl-6-(4-hydroxyphenyl)-2-<4-(3-trifluoromethyl(diazirin-3-yl))benzyl>-3,7-fihydroimidazo<1,2-a>pyrazin-3-one 
• 40040-83-3 3,7-dihydro-2-methyl-6-(p-hyroxyphenyl)-8-benzylimidazolo[1,2-a]pyrazin-3-one 
• 217481-38-4 C₂₆⁽¹³⁾CH₂₃N₃O₃ 
• 276879-69-7 2-(p-methoxybenzyl)-6-(p-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one 

Relevant articles and documents

Synthesis of 2-amino-3-benzyl-5-(p-hydroxyphenyl)pyrazine

2-Amino-3-benzyl-5-(p-hydroxyphenyl)pyrazine (2), a precursor of Watasenia preluciferin (coelenterazine) (1), is widely distributed in marine bioluminescent animals. It was prepared from p-hydroxyphenylglyoxal aldoxime (5) in two steps; by condensation wi

Formation of Coelenteramine from 2-Peroxycoelenterazine in the Ca2+-Binding Photoprotein Aequorin

Aequorin consists of apoprotein (apoAequorin) and (S)-2-peroxycoelenterazine (CTZ-OOH) and is considered to be a transient-state complex of an enzyme (apoAequorin) and a substrate (coelenterazine and molecular oxygen) in the enzymatic reaction. The degradation process of CTZ-OOH in aequorin was characterized under various conditions of protein denaturation. By acid treatment, the major product from CTZ-OOH was coelenteramine (CTM), but not coelenteramide (CTMD), and no significant luminescence was observed. The counterparts of CTM from CTZ-OOH were identified as 4-hydroxyphenylpyruvic acid (4HPPA) and 4-hydroxyphenylacetic acid (4HPAA) by liquid chromatography/electrospray ionization–time-of-flight mass spectrometry (LC/ESI-TOF-MS). In the luminescence reaction of aequorin with Ca2+, similar amounts of 4HPPA and 4HPAA were detected, indicating that CTM is formed by two pathways from CTZ-OOH through dioxetanone anion and not by hydrolysis from CTMD.

Multicomponent synthesis of novel coelenterazine derivatives substituted at the C-3 position

Three novel coelenterazine derivatives substituted at the C-3 position were synthesized through a multicomponent strategy based on Groebke-Blackburn-Bienaymé reaction without using protecting groups. An efficient one-pot tert-butyl group cleavage from an