14097-24-6Relevant articles and documents
Microwave-assisted solid reaction: Reduction of ketones using sodium borohydride
Chen, Same-Ting
, p. 509 - 511 (1999)
A general and efficient procedure for microwave-assisted reduction of liquid and solid ketones using sodium borohydride without solvents is described. The added support can enhance both the efficiency and chemoselectivity of reduction.
Nickel-catalysed three-component connection reaction of a phenyl group, conjugated dienes, and aldehydes: Stereoselective synthesis of (E)-5-phenyl-3-penten-1-ols and (E)-3-methyl-5-phenyl-3-penten-1-ols
Shibata, Kazufumi,Kimura, Masanari,Kojima, Keisuke,Tanaka, Shuji,Tamaru, Yoshinao
, p. 348 - 353 (2001)
In the presence of 10 mol% of Ni(acac)2, Ph2Zn reacts with 1,3-butadiene and aldehydes at room temperature to give 1-alkyl and 1-aryl substituted (E)-5-phenyl-3-penten-1-ols (3) in good yields. Under similar conditions, the three components of Ph3BZnEt2, isoprene, and aldehydes combine with each other to furnish 1-alkyl and 1-aryl substituted (E)-3-methyl-5-phenyl-3-penten-1-ols (5) in good yields.
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Brewin,Turner
, p. 502 (1930)
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Selective C-alkylation Between Alcohols Catalyzed by N-Heterocyclic Carbene Molybdenum
Liu, Jiahao,Li, Weikang,Li, Yinwu,Liu, Yan,Ke, Zhuofeng
supporting information, p. 3124 - 3128 (2021/09/20)
The first implementation of a molybdenum complex with an easily accessible bis-N-heterocyclic carbene ligand to catalyze β-alkylation of secondary alcohols via borrowing-hydrogen (BH) strategy using alcohols as alkylating agents is reported. Remarkably high activity, excellent selectivity, and broad substrate scope compatibility with advantages of catalyst usage low to 0.5 mol%, a catalytic amount of NaOH as the base, and H2O as the by-product are demonstrated in this green and step-economical protocol. Mechanistic studies indicate a plausible outer-sphere mechanism in which the alcohol dehydrogenation is the rate-determining step.
Application of 4, 6-dimethyl-2-mercaptopyrimidine bivalent nickel complex in preparation of [alpha]-alkyl ketone
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Paragraph 0019, (2021/04/07)
The invention relates to the field of metal organic chemistry, in particular to application of a 4, 6-dimethyl-2-mercaptopyrimidine bivalent nickel complex in preparation of [alpha]-alkyl ketone, which takes a 4, 6-dimethyl-2-mercaptopyrimidine nickel (II) compound as a catalyst and realizes selective preparation of [alpha]-alkyl ketone through cross-coupling reaction of secondary alcohol and primary alcohol by regulating and controlling reaction conditions. The coupling reaction is carried out in anhydrous toluene in the presence of alkali under the protection of inert gas. The application has the advantages of mild reaction system conditions and wide substrate applicability, and effectively avoids the use of organic phosphine ligands and noble metals.
