1421312-32-4

Basic information

• Product Name: C₁₇H₁₃NO₅
• Synonyms: C₁₇H₁₃NO₅
• CAS NO: 1421312-32-4
• Molecular Weight: 311.294
• Mol File: 1421312-32-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 556.6±50.0 °C(Predicted)
• Density: 1.394±0.06 g/cm3(Predicted)
• CAS DataBase Reference: C₁₇H₁₃NO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₃NO₅(1421312-32-4)
• EPA Substance Registry System: C₁₇H₁₃NO₅(1421312-32-4)

Safety Data

• Hazardous Substances Data: 1421312-32-4(Hazardous Substances Data)

Upstream product

• 31643-49-9 4-Nitrophthalonitrile 
• 38791-62-7 4-phenoxyphthalonitrile 
• 37951-15-8 4-phenoxyphthalic acid 
• 21345-01-7 4-phenoxyphthalic anhydride 
• 1421312-31-3 C₁₈H₁₃NO₆ 

Downstream Products

• 808118-40-3 [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid 
• 1421312-33-5 methyl 4-hydroxy-1-chloro-7-phenoxyisoquinoline-3-carboxylate 
• 1421312-34-6 4-hydroxy-1-methyl-7-phenoxyisoquinolinyl-3-carboxylic acid methyl ester 
• 1421312-35-7 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid 
• 1421312-36-8 [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester 

Relevant articles and documents

Preparation method of roxadustat intermediate

The invention discloses a preparation method of a roxadustat intermediate. The method comprises the following steps: anhydride ring opening, esterification, ring closing, aromatization, deprotection, chlorination and methylation to obtain the roxadustat intermediate. According to the invention, the preparation method provided by the invention makes full use of the atom economy theory, is easy to operate, low in cost and low in pollution, and is suitable for large-scale industrial production; and only one-time refining is carried out, the chromatographic purity can reach 99.5% or above, and the total yield of the six-step reaction is 30% or above.

CRYSTAL TYPES OF COMPOUNDS INHIBITING ACTIVITY OF PROLYL HYDROXYLASE AND USE THEREOF

The invention relates to crystal types of compound shown as structural formula I, methods of preparing the compound, intermediate, pharmaceutical composition, and use of treating disease or pharmaceutical preparations for treating disease.

POLYMORPHIC FORMS OF COMPOUNDS AS PROLYL HYDROXYLASE INHIBITOR, AND USES THEREOF

The present invention relates to the polymorphic forms of the compound of Formula (I), preparation thereof including the preparation of intermediates and pharmaceutical compositions, and use of a polymorph above in the treatment of a disease, a disorder o