1421312-34-6

Basic information

• Product Name: fg-4592 int 2
• Synonyms: fg-4592 int 2;methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate;1 - methyl - 4 - hydroxy - 7 - phenoxy isoquinoline - 3 - methyl formate;4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester;Fg-4592/FG4592 int 2
• CAS NO: 1421312-34-6
• Molecular Formula: C₁₈H₁₅NO₄
• Molecular Weight: 309.316
• EINECS: -0
• Product Categories: API
• Mol File: 1421312-34-6.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 537.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.289±0.06 g/cm3(Predicted)
• PKA: 6.24±0.50(Predicted)
• CAS DataBase Reference: fg-4592 int 2(CAS DataBase Reference)
• NIST Chemistry Reference: fg-4592 int 2(1421312-34-6)
• EPA Substance Registry System: fg-4592 int 2(1421312-34-6)

Safety Data

• Hazardous Substances Data: 1421312-34-6(Hazardous Substances Data)

Usage

Description

fg-4592 int 2, also known as 4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid, is a chemical compound with significant applications in the pharmaceutical industry. It is characterized by its unique molecular structure and properties, which make it a valuable component in the development of certain drugs.

Uses

Used in Pharmaceutical Industry:
fg-4592 int 2 is used as a reagent for the preparation of Roxadustat (H948180), a drug that is utilized in the treatment of anemia and chronic renal insufficiency. Its role in the synthesis process is crucial, as it contributes to the development of a medication that can help improve the quality of life for patients suffering from these conditions.

Upstream product

• 31643-49-9 4-Nitrophthalonitrile 
• 38791-62-7 4-phenoxyphthalonitrile 
• 593-90-8 trimethylborane 
• 1421312-33-5 methyl 4-hydroxy-1-chloro-7-phenoxyisoquinoline-3-carboxylate 
• 37951-15-8 4-phenoxyphthalic acid 
• 21345-01-7 4-phenoxyphthalic anhydride 
• 1421312-31-3 C₁₈H₁₃NO₆ 
• 1421312-32-4 C₁₇H₁₃NO₅ 
• 1455091-04-9 2-(chloromethyl)-4-phenoxybenzoic acid methyl ester 
• 1455091-06-1 2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester 
• 1455091-10-7 4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester 
• 1455091-21-0 1-bromo-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester 
• 594-27-4 tetramethylstannane 
• 64169-34-2 5-bromophthalide 

Downstream Products

• 808118-40-3 [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid 
• 1421312-35-7 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid 
• 1421312-36-8 [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester 
• 1455089-22-1 3-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid 

Relevant articles and documents

A General Organocatalytic System for Electron Donor-Acceptor Complex Photoactivation and Its Use in Radical Processes

We report herein a modular class of organic catalysts that, acting as donors, can readily form photoactive electron donor-acceptor (EDA) complexes with a variety of radical precursors. Excitation with visible light generates open-shell intermediates under mild conditions, including nonstabilized carbon radicals and nitrogen-centered radicals. The modular nature of the commercially available xanthogenate and dithiocarbamate anion organocatalysts offers a versatile EDA complex catalytic platform for developing mechanistically distinct radical reactions, encompassing redox-neutral and net-reductive processes. Mechanistic investigations, by means of quantum yield determination, established that a closed catalytic cycle is operational for all of the developed radical processes, highlighting the ability of the organic catalysts to turn over and iteratively drive every catalytic cycle. We also demonstrate how the catalysts' stability and the method's high functional group tolerance could be advantageous for the direct radical functionalization of abundant functional groups, including aliphatic carboxylic acids and amines, and for applications in the late-stage elaboration of biorelevant compounds and enantioselective radical catalysis.

Preparation method of isoquinolinone compound

The invention relates to a preparation method of an isoquinolinone compound. Specifically, the method for preparing the compound shown in the formula 2 comprises the step that a compound shown in a formula b reacts with a methylation reagent to obtain the compound shown in the formula 2. The method provided by the invention is used for preparing the isoquinolinone compound (such as Roxadustat), and has the excellent effects of reasonable route, convenience, feasibility, high yield, high purity, suitability for industrial production and the like.

Preparation method of isoquinoline derivative

Disclosed is a preparation method of an isoquinoline derivative. A preparation method of a compound represented by a general formula II, i.e., 4-hydroxy-1-methyl-7-phenoxy isoquinoline-3-formate, is provided, wherein substituent definitions are as defined in the specification. The preparation method comprises the following steps of: under an acidic condition, dissolving a compound shown as a structural formula III in dimethyl sulfoxide, catalyzing by a ferrous ion (Fe) catalyst, and oxidizing by H2O2 to obtain the 4-hydroxy-1-methyl- 7-phenoxy isoquinoline-3-formate shown as the structuralformula II. By using the method, the production efficiency can be greatly improved, the production cost is reduced, the product purity can be ensured, and the method is suitable for industrial mass production.