14802-30-3

Basic information

• Product Name: 1-(4-Methylphenyl)-3-phenylprop-2-en-1-one
• Synonyms: (2E)-1-(4-methylphenyl)-3-phenylprop-2-en-1-one
• CAS NO: 14802-30-3
• Molecular Formula: C₁₆H₁₄O
• Molecular Weight: 222.28176
• Mol File: 14802-30-3.mol
• Article Data: 98

Chemical Properties

• Melting Point: 69.5-75.9 °C
• Boiling Point: 373.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.078±0.06 g/cm3(Predicted)
• Solubility: soluble in Methanol
• CAS DataBase Reference: 1-(4-Methylphenyl)-3-phenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Methylphenyl)-3-phenylprop-2-en-1-one(14802-30-3)
• EPA Substance Registry System: 1-(4-Methylphenyl)-3-phenylprop-2-en-1-one(14802-30-3)

Safety Data

• Hazardous Substances Data: 14802-30-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 122-00-9 para-methylacetophenone 
• 102-92-1 Cinnamoyl chloride 
• 108-88-3 toluene 
• 72758-71-5 3c-phenyl-1-p-tolyl-propenone 
• 66866-14-6 acetyl-p-methylphenyltriphenylarsonium bromide 
• 138043-33-1 2,2-Dimethyl-3-phenyl-5-p-tolyl-isoxazolidin-2-ium; iodide 
• 10325-65-2 2,3-Dibromo-3-phenyl-1-p-tolyl-propan-1-one 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 
• 536-74-3 phenylacetylene 
• 150015-89-7 (3-oxo-1-phenyl-3-p-tolyl-propyl)-malonic acid diethyl ester 
• 51246-20-9 1-phenyl-1-iodoethylene 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 26957-11-9 5-morpholin-4-yl-3-phenyl-1-p-tolyl-pentan-1-one 
• 132042-61-6 C₂₆H₂₆N₂O₄S 
• 101854-97-1 3-methoxyamino-3-phenyl-1-p-tolyl-propan-1-one 
• 106368-99-4 ((3R,4S)-1-Methyl-4-phenyl-pyrrolidin-3-yl)-p-tolyl-methanone 
• 116509-24-1 4-methyl-4-nitro-3-phenyl-1-(p-tolyl)pentan-1-one 
• 86118-53-8 (4-Methylphenyl)(c-2,t-3-diphenylcycloprop-r-1-yl)methanon 
• 603-35-0 triphenylphosphine 
• 113273-72-6 (2S,3R,4S,5R)-4-(4-Methyl-benzoyl)-3,5-diphenyl-pyrrolidine-2-carboxylic acid methyl ester 
• 72666-51-4 2-Biphenyl-4-yl-4-phenyl-6-p-tolyl-pyridine 
• 107710-44-1 Dithiocarbamic acid 3-oxo-1-phenyl-3-p-tolyl-propyl ester 
• 32046-97-2 (αR,βS)-2,3-epoxy-4'-methyl-3-phenylpropiophenone 
• 189017-49-0 (αS,βR)-2,3-epoxy-4'-methyl-3-phenylpropiophenone 
• 5012-90-8 4-methylphenyl phenethyl ketone 
• 72758-71-5 3c-phenyl-1-p-tolyl-propenone 

Relevant articles and documents

Efficient synthesis of chalcones by a solid base catalyst

A simple and efficient heterogeneous procedure has been developed for the synthesis of chalcones (α,β-unsaturated ketones) by the Claisen-Schmidt condensation between arylaldehydes and ketones using Mg-Al-OtBu hydrotalcite (HT-OtBu) as catalyst. Copyright Taylor & Francis, Inc.

Synthesis of chalcones catalyzed by aminopropylated silica sol-gel under solvent-free conditions

Aminopropylated nanosilica was prepared by a simple sol-gel process from tetraethyl orthosilicate (TEOS) and then it was functionalized with different amounts of 3-aminopropyltriethoxysilane (APS) under toluene reflux. The prepared solids were characterized by means of XRD, FT-IR, TGA-DTA, SEM-EDS, and TEM. Their textural properties were determined by adsorption-desorption isotherms of N2 at 77 K. It was proved that the amount of APS used in the preparation process had a great influence on the physicochemical properties of the hybrid organic-inorganic solid materials. The materials were used as catalyst in the Claisen-Schmidt preparation of chalcones for the reaction of substituted acetophenones and benzaldehydes under solvent-free conditions. The result showed that the presence of a high amount of aminopropyl groups was important for a very good performance of the catalyst in the substrate conversion. Also, the influence of different groups in the aromatic ring of acetophenones and benzaldehydes was investigated. In all cases, coproduct formation was not observed; the catalysts were recovered and can be recycled twice without appreciable loss of reactivity.

Aluminosilicate catalysis of chalcone Diels-Alder reactions

Previously unreported Diels-Alder adducts of substituted chalcones with isoprene and myrcene have been formed at more than 0°C by employing a nanoporous aluminosilicate catalyst. This catalyst eliminates problems with diene polymerization that are encountered with many other Lewis acids. The chalcone component has some size restrictions. Copyright Taylor & Francis Group, LLC.

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Orchestrating a β-Hydride Elimination Pathway in Palladium(II)-Catalyzed Arylation/Alkenylation of Cyclopropanols Using Organoboron Reagents

The scope of chemoselective β-hydride elimination in the context of arylation/alkenylation of homoenolates from cyclopropanol precursors using organoboronic reagents as transmetalation coupling partners was examined. The reaction optimization paradigm revealed a simple ligand-free Pd(II) catalytic system to be most efficient under open air conditions. The preparative scope, which was investigated with 48 examples, supported the applicability of this reaction to a wide range of substrates tolerating a variety of functional groups while delivering β-substituted enone and dienone derivatives in 62-95% yields.

Green method for high-selectivity synthesis of chalcone compounds

Under the condition of air, the water-soluble inorganic weak base is used as a catalyst to catalyze the hydrogen transfer reaction of the propargyl alcohol compound, so that the green synthesis of the high-trans selective chalcone compound is realized. Reaction temperature: 80 - 120 °C and reaction time 12 - 48 hours. To the technical scheme, any transition metal catalyst and ligand do not need to be used, inert gas protection is not needed, no other byproducts are generated, the atom economy 100%, green and environment friendliness are avoided, and the product is a high-selectivity (E)-type product. The reaction conditions are relatively low in requirement. Compared with the prior art, the alkali catalyst is obvious in advantages, and has a certain application prospect in the fields of organic synthesis, biochemistry, medicine and the like.