167316-06-5

Basic information

• Product Name: L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-L-tyrosyl-, methyl ester
• CAS NO: 167316-06-5
• Molecular Formula: C19H28N2O6
• Molecular Weight: 380.441
• Mol File: 167316-06-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-L-tyrosyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-L-tyrosyl-, methyl ester(167316-06-5)
• EPA Substance Registry System: L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-L-tyrosyl-, methyl ester(167316-06-5)

Safety Data

• Hazardous Substances Data: 167316-06-5(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 
• 188966-57-6 Boc-L-Tyr-L-Ala-OMe 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 60-18-4 L-tyrosine 
• 94790-24-6 (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoate 
• 6230-11-1 O-Methyltyrosine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2491-20-5 L-alanine methyl ester hydrochloride 
• 53267-93-9 O-methyl-N-tert-butoxycarbonyl-L-tyrosine 

Downstream Products

• 944059-32-9 C₁₉H₂₇N₂O₆I 
• 167316-10-1 BOC-D-alanyl-L-alanyl-O⁴-methyl-L-tyrosyl-L-alanyl-L-tyrosyl-N,O⁴-dimethyl-L-tyrosine cyclic 5⁴<*>6³ ether, methyl ester 
• 167316-08-7 BOC-D-alanyl-L-alanyl-O-methyl-L-tyrosyl-L-alanyl-N-methyl-L-tyrosyl-N,O⁴-dimethyl-L-tyrosine cyclic 5⁴<*>6³ ether, methyl ester 
• 167316-11-2 BOC-D-alanyl-L-alanyl-O⁴-methyl-L-tyrosyl-L-alanyl-N-methyl-L-tyrosyl-O⁴-methyl-L-tyrosine cyclic 5⁴<*>6³ ether, methyl ester 
• 167316-13-4 BOC-D-alanyl-L-alanyl-O⁴-methyl-L-tyrosyl-L-alanyl-L-tyrosyl-O⁴-methyl-L-tyrosine cyclic 5⁴<*>6³ ether, methyl ester 
• 167316-16-7 C₄₄H₅₆N₆O₁₂ 
• 167316-19-0 C₄₃H₅₄N₆O₁₂ 
• 167316-14-5 C₄₅H₅₈N₆O₁₂ 
• 167316-17-8 C₄₄H₅₆N₆O₁₂ 
• 167316-07-6 BOC-D-Ala-L-Ala-L-Tyr(OMe)-L-Ala-OMe 
• 167316-05-4 BOC-D-Ala-L-Ala-L-Tyr(OMe)-L-Ala-OH 
• 161635-05-8 BOC-D-Ala-L-Ala-L-Tyr(OMe)-L-Ala-OC₆F₅ 
• 137606-77-0 RA-VII 
• 684233-21-4 (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-3-(4-methoxy-phenyl)-propionylamino]-propionic acid methyl ester 

Relevant articles and documents

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Five new analogs 4-8 of rubiyunnanin B (1), mainly modified on the tetrapeptide subunit, were synthesized. These agents 4-8 were substituted d-Ala-l-Ala-l-Tyr(OMe)-l-Ala, d-Ala-l-Ala-l-Phe-l-Ala, d-Ala-l-Ala-l-Try-l-Ala, d-Ala-l-Ala-l-Pro-l-Ala, and d-Ala-l-Ala-l-Ala for the d-Ala-l-Ala-l-N-Me-Tyr(OMe)-l-Ala tetrapeptide subunit. Unlike the natural product, the synthetic agents 4-8 adopt only a single solution conformation, and the central peptide bond in the cyclodityrosine subunit of compounds 4-8 adopt trans stereochemistry. Cytotoxic activities of analogs 4-8 against three human cancer cell lines including A549, BGC-823, and HeLa were evaluated and all the five synthesized peptides exhibited no effects against the test cell lines. These compounds were also evaluated for their antiinsulin resistance and insulin sensitizing activities and none of them showed activity in these assays.

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