184848-89-3Relevant articles and documents
Preparation method of N-(2-methoxycarbonyl vinyl)-4, 4, 4-trifluoro-3-ketone-1-buteneamine
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Paragraph 0017-0018; 0020-0021; 0023-0024; 0026-0027; ..., (2021/07/17)
The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of N-(2-methoxycarbonyl vinyl)-4, 4, 4-trifluoro-3-ketone-1-buteneamine, and the preparation method of N-(2-methoxycarbonyl vinyl)-4, 4, 4-trifluoro-3-ketone-1-buteneamine comprises the following steps: taking trifluoroacetic acid, vinyl ethyl ether, methylsulfonyl chloride and pyridine as raw materials, firstly preparing 4-ethoxy-1, 1, 1-trifluoro-3-butene-2-ketone, carrying out ammonia ammoniation to obtain 4-amino-1, 1, 1-trifluoro-3-butene-2-ketone, then, under the action of sodium hydroxide, reacting with methyl 3-methoxyacrylate to obtain a target product N-(2-methoxycarbonyl vinyl)-4, 4, 4-trifluoro-3-ketone-1-buteneamine. The adopted raw materials are relatively cheap and easy to obtain, and the method is easy and convenient to operate, safe, feasible, high in cost performance and suitable for industrial production.
A straightforward preparation of fluorine-containing 1,2-dihydropyrimidines and pyrimidines with 2,2-dihydropolyfluoroalkylaldehydes
Yang, Xian-Jin,Zhang, Li-Si,Liu, Jin-Tao
, p. 5643 - 5648 (2008/01/05)
The reactions of 2,2-dihydropolyfluoroalkylaldehydes with ammonia and enol ethers or carbonyl compounds are described. In the presence of zinc chloride, all reactions took place readily in THF at 50 °C to give fluorine-containing 1,2-dihydropyrimidines in
A new method for the synthesis of CF3-containing aminovinyl ketones
Krasovsky,Nenajdenko,Balenkova
, p. 1395 - 1400 (2007/10/03)
A new method for the synthesis of aminovinyl trifluoroinethyl ketones was developed. The method is based on the reactions of 4-sulfonyl-1,1,1-trifluorobut-3-ene-2,2-diols with various alkyl-, aryl-, dialkyl-, and alkylarylamines. The stereochemistry of the compounds obtained was studied.