221530-44-5 Usage
Description
(1,2,6,7,-Tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile is a white solid chemical compound that belongs to the indenofuran class. It is primarily used as an intermediate in the synthesis of pharmaceuticals, specifically for the development of drugs targeting sleep disorders.
Uses
Used in Pharmaceutical Industry:
(1,2,6,7,-Tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile is used as an intermediate for the synthesis of pharmaceuticals for the treatment of sleep disorders. Its unique chemical structure allows it to be a key component in the development of drugs that can effectively address sleep-related issues.
Used in Ramelteon Production:
(1,2,6,7,-Tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile is used as a Ramelteon intermediate, which is an essential step in the production of Ramelteon. Ramelteon is a medication prescribed for the treatment of insomnia, particularly for patients who have difficulty falling asleep or staying asleep.
Used in Sleep Disorder Treatment:
(1,2,6,7,-Tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile is used as a crucial component in the development of pharmaceuticals aimed at treating sleep disorders. Its role as an intermediate in the synthesis of such drugs highlights its importance in creating effective treatments for individuals suffering from sleep-related issues.
Check Digit Verification of cas no
The CAS Registry Mumber 221530-44-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,5,3 and 0 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 221530-44:
(8*2)+(7*2)+(6*1)+(5*5)+(4*3)+(3*0)+(2*4)+(1*4)=85
85 % 10 = 5
So 221530-44-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H11NO/c14-7-5-10-2-1-9-3-4-12-11(13(9)10)6-8-15-12/h3-5H,1-2,6,8H2/b10-5+
221530-44-5Relevant articles and documents
A novel and practical synthesis of ramelteon
Xiao, Sa,Chen, Chao,Li, Hongyan,Lin, Kuaile,Zhou, Weicheng
, p. 373 - 377 (2015)
An efficient and practical process for the synthesis of ramelteon 1, a sedative-hypnotic, is described. Highlights in this synthesis are the usage of acetonitrile as nucleophilic reagent to add to 4,5-dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one 2 and the subsequent hydrogenation which successfully implement four processes (debromination, dehydration, olefin reduction, and cyano reduction) into one step to produce the ethylamine compound 13 where dibenzoyl-l-tartaric acid is selected both as an acid to form the salt in the end of hydrogenation and as the resolution agent. Then, target compound 1 is easily obtained from 13 via propionylation. The overall yield in this novel and concise process is almost twice as much as those in the known routes, calculated on compound 2.
