448964-37-2Relevant articles and documents
Preparation method of ramelteon
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Paragraph 0016-0022, (2020/06/16)
The invention belongs to the field of medicinal chemistry, and mainly relates to a (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)-1-ethylamine compound represented by a formula I. The method has the advantages that the operation is simple, the steps are reduced compared with the previous method, the route is shortened, and the used solvent is single in variety, convenient to recycle and high in yield, wherein the formula I is defined in the specification.
Preparation of 2 - (1, 6, 7, 8 - tetrahydro - 2H - indenyl and [5, 4 - b] furan - 8 - subunit of ethylamine
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Paragraph 0051-0068, (2017/08/25)
The invention discloses a method for preparing 2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-idenethamine. The method comprises the following steps: (a) synthesizing a compound of a structural formula (III) by taking a compound of a structural formula (II) as an initial raw material under the conditions of certain temperature, catalyst, carbonic acid ditert-butyl ester, solvent and hydrogen source; (b) generating 2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-idenethamine from the compound of the structural formula (III) under the conditions of certain temperature, acid and solvent. In addition, the invention further discloses a novel compound, namely the compound of the structural formula (III). By adopting the method, the defects that the reaction of the conventional method is hard to control, the reaction time is too long and byproducts such as secondary amine and tertiary amine are easy to produce in the reaction process, are avoided.
PROCESS OF MAKING RAMELTEON AND RELATED SUBSTANCES
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, (2009/01/24)
The present patent application provides a process for the preparation of compounds of the Formula (I) Wherein represents a single bond or a double bond. R represents ethyl, vinyl or ethynyl.