26131-22-6

Basic information

• Product Name: 1-(4-chloro-benzoyl)-4-ethyl-thiosemicarbazide
• Synonyms: 1-(4-chloro-benzoyl)-4-ethyl-thiosemicarbazide
• CAS NO: 26131-22-6
• Molecular Weight: 257.744
• Mol File: 26131-22-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(4-chloro-benzoyl)-4-ethyl-thiosemicarbazide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chloro-benzoyl)-4-ethyl-thiosemicarbazide(26131-22-6)
• EPA Substance Registry System: 1-(4-chloro-benzoyl)-4-ethyl-thiosemicarbazide(26131-22-6)

Safety Data

• Hazardous Substances Data: 26131-22-6(Hazardous Substances Data)

Upstream product

• 13431-34-0 N-ethylthiosemicarbazide 
• 122-01-0 4-chloro-benzoyl chloride 
• 74-11-3 para-chlorobenzoic acid 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 542-85-8 Ethyl isothiocyanate 
• 536-40-3 4-chlorobenzoic acid hydrazide 

Downstream Products

• 150535-90-3 2-[5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-propionic acid methyl ester 
• 150536-02-0 2-[5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-propionic acid 
• 150535-89-0 [5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid methyl ester 
• 150536-01-9 [5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid 
• 26131-64-6 5-(4-Chloro-phenyl)-4-ethyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 26131-64-6 5-(4-chlorophenyl)-4-ethyl-1,2,4-triazole-3-thiol 
• 35317-61-4 [5-(4-chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-ethyl-amine 
• 31409-18-4 3-(4-chloro-phenyl)-4-ethyl-5-methylsulfanyl-4H-[1,2,4]triazole 

Relevant articles and documents

Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity

New N-4-piperazinyl ciprofloxacin-triazole hybrids 6a-o were prepared and characterized. The in vitro antimycobacterial activity revealed that compound 6a experienced promising antimycobacterial activity against Mycobactrium smegmatis compared with the reference isoniazide (INH). Additionally, compound 6a exhibited broad spectrum antibacterial activity against all the tested strains either Gram-positive or Gram-negative bacteria compared with the reference ciprofloxacin. Also, compounds 6g and 6i displayed considerable antifungal activity compared with the reference ketoconazole. DNA cleavage assay of the highly active compounds 6c and 6h showed a good correlation between the Mycobactrium cleaved DNA gyrase assay and their in vitro antimycobactrial activity. Moreover, molecular modeling studies were done for the designed ciprofloxacin derivatives to predict their binding modes towards Topoisomerase II enzyme (PDB: 5bs8).

Synthesis of [(4,5-disubstituted-4H-1,2,4-triazol-3-yl)thio]alkanoic acids and their analogues as possible antiinflammatory agents

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