26131-64-6

Basic information

• Product Name: 5-(4-CHLORO-PHENYL)-4-ETHYL-4H-[1,2,4]TRIAZOLE-3-THIOL
• Synonyms: 5-(4-chlorophenyl)-4-ethyl-2H-1,2,4-triazole-3-thione
• CAS NO: 26131-64-6
• Molecular Formula: C₁₀H₁₀ClN₃S
• Molecular Weight: 239.73
• Mol File: 26131-64-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 313.9°Cat760mmHg
• Flash Point: 143.6°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 0.000483mmHg at 25°C
• Refractive Index: 1.674
• CAS DataBase Reference: 5-(4-CHLORO-PHENYL)-4-ETHYL-4H-[1,2,4]TRIAZOLE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-CHLORO-PHENYL)-4-ETHYL-4H-[1,2,4]TRIAZOLE-3-THIOL(26131-64-6)
• EPA Substance Registry System: 5-(4-CHLORO-PHENYL)-4-ETHYL-4H-[1,2,4]TRIAZOLE-3-THIOL(26131-64-6)

Safety Data

• Hazardous Substances Data: 26131-64-6(Hazardous Substances Data)

Usage

Main properties

1. Chemical name: 5-(4-chloro-phenyl)-4-ethyl-4H-[1,2,4]triazole-3-thiol
2. Molecular formula: C7H7ClN4S
3. Chemical class: Organic compound
4. Therapeutic class: Antihistamine medication

Specific content

1. Also known as cetirizine
2. Chemical derivative of triazole and thiol
3. Used to treat symptoms of allergies, such as sneezing, runny nose, and itchy or watery eyes
4. Works by blocking the action of histamine in the body
5. Available over-the-counter in the form of tablets or syrup
6. Considered a safe and effective treatment for allergies with minimal side effects.

InChI:InChI=1/C10H10ClN3S/c1-2-14-9(12-13-10(14)15)7-3-5-8(11)6-4-7/h3-6H,2H2,1H3,(H,13,15)

Upstream product

• 26131-22-6 1-(4-chloro-benzoyl)-4-ethyl-thiosemicarbazide 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 150535-89-0 [5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid methyl ester 
• 150535-90-3 2-[5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-propionic acid methyl ester 
• 82100-36-5 3-(p-chlorophenyl)-4-ethyl-S-(2-p-phenacyl)-mercapto-1,2,4-triazole 
• 31409-18-4 3-(4-chloro-phenyl)-4-ethyl-5-methylsulfanyl-4H-[1,2,4]triazole 
• 150536-01-9 [5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid 
• 150536-02-0 2-[5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-propionic acid 

Relevant articles and documents

Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity

New N-4-piperazinyl ciprofloxacin-triazole hybrids 6a-o were prepared and characterized. The in vitro antimycobacterial activity revealed that compound 6a experienced promising antimycobacterial activity against Mycobactrium smegmatis compared with the reference isoniazide (INH). Additionally, compound 6a exhibited broad spectrum antibacterial activity against all the tested strains either Gram-positive or Gram-negative bacteria compared with the reference ciprofloxacin. Also, compounds 6g and 6i displayed considerable antifungal activity compared with the reference ketoconazole. DNA cleavage assay of the highly active compounds 6c and 6h showed a good correlation between the Mycobactrium cleaved DNA gyrase assay and their in vitro antimycobactrial activity. Moreover, molecular modeling studies were done for the designed ciprofloxacin derivatives to predict their binding modes towards Topoisomerase II enzyme (PDB: 5bs8).

5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents

Selected examples from three series of isomeric (alkylthio)-1,2,4- triazoles were prepared and examined for anticonvulsant activity versus strychnine-, maximal-electroshock-, pentylenetetrazole-, and 3- mercaptopropionic-acid-induced seizures in mice. A n