329185-67-3

Basic information

• Product Name: 1H-Indole-5-carboxamide, N-phenyl-
• CAS NO: 329185-67-3
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Mol File: 329185-67-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Indole-5-carboxamide, N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-5-carboxamide, N-phenyl-(329185-67-3)
• EPA Substance Registry System: 1H-Indole-5-carboxamide, N-phenyl-(329185-67-3)

Safety Data

• Hazardous Substances Data: 329185-67-3(Hazardous Substances Data)

Usage

Structure

An amide derivative of indole with a phenyl group attached to the nitrogen atom of the carboxamide group

Usage

Widely used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceutical drugs

Biological activity

The N-phenylsubstitution enhances the biological activity of the compound

Potential applications

As an antitumor agent, analgesic, anti-inflammatory, and inhibitor of protein kinase C

Promise

Showing promise as a potential candidate for the development of novel therapeutic agents

Upstream product

• 16066-91-4 5-iodo-1H-indole 
• 201230-82-2 carbon monoxide 
• 62-53-3 aniline 
• 32996-16-0 ethyl indole-5-carboxylate 
• 329185-63-9 1-(N,N-dimethylsulfamoyl)-1H-indole-5-(N-phenyl)carboxamide 

Downstream Products

• 329185-63-9 1-(N,N-dimethylsulfamoyl)-1H-indole-5-(N-phenyl)carboxamide 

Relevant articles and documents

Functionalization of indole at C-5 or C-7 via palladium-catalysed double carbonylation. A facile synthesis of indole ketocarboxamides and carboxamide dimers

Palladium-catalysed aminocarbonylation of 7-iodoindole derivatives (the parent compound and 5-bromo-7-iodoindole), as well as 5-iodoindole with various primary and secondary amines, including amino acid esters and chiral diamines, was carried out. In this

NOVEL RHO KINASE INHIBITORS AND METHODS OF USE

The subject invention concerns materials and methods for treating diseases and disorders associated with expression of Rho associated kinases (ROCKs). Examples of diseases and disorders contemplated within the scope of the invention include, but are not limited to, oncological disorders, cardiovascular diseases, CNS disorders, and inflammatory disorders. In one embodiment, a method of the invention comprises administering a therapeutically effective amount of one or more compounds of the present invention, or a composition comprising the compounds, to a person or animal in need of treatment. The subject invention also concerns compounds that inhibit ROCKs, and compositions that comprise the inhibitor compounds of the invention. Compounds contemplated within the scope of the invention include, but are not limited to, those compounds shown in Table (5).

Efficient electrochemical cleavage of N,N-dimethylaminosulfonyl-protected indoles

Indoles protected at the N-1 position with the N,N-dimethylaminosulfonyl group were efficiently deprotected by electrolysis. Yields were in the 80-90% range and the method was compatible with a number of functional groups (nitrile, ester, chloride, carboxamide). (C) 2000 Elsevier Science Ltd.