32996-16-0

Basic information

• Product Name: ETHYL INDOLE-5-CARBOXYLATE
• Synonyms: RARECHEM AL BI 0874;INDOLE-5-CARBOXYLIC ACID ETHYL ESTER;ETHYL INDOLE-5-CARBOXYLATE;5-CARBETHOXYINDOLE;1H-Indole-5-carboxylicacidethylester;INDOLE-5-CARBOXYLIC ACID ETHYL ESTER (I5CAEt);ethyl 1H-indole-5-carboxylate
• CAS NO: 32996-16-0
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21
• Product Categories: Indoles and derivatives;Heterocycle-Indole series
• Mol File: 32996-16-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 96.5-97.5 °C
• Boiling Point: 342.357°C at 760 mmHg
• Flash Point: 160.852°C
• Appearance: /
• Density: 1.211g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.09±0.30(Predicted)
• CAS DataBase Reference: ETHYL INDOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL INDOLE-5-CARBOXYLATE(32996-16-0)
• EPA Substance Registry System: ETHYL INDOLE-5-CARBOXYLATE(32996-16-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 32996-16-0(Hazardous Substances Data)

Usage

Description

Ethyl Indole-5-carboxylate is an organic compound with the chemical formula C10H9NO2. It is a derivative of indole, which is a heterocyclic aromatic organic compound. Ethyl Indole-5-carboxylate is characterized by its unique chemical structure and properties, making it a valuable compound in various applications.

Uses

Used in Pharmaceutical Industry:
Ethyl Indole-5-carboxylate is used as a reagent for the synthesis of pyrazole-based cathepsin S inhibitors. Cathepsin S is a lysosomal cysteine protease that plays a crucial role in the immune system and has been implicated in various diseases, including cancer and neurodegenerative disorders. By inhibiting cathepsin S, these pyrazole-based inhibitors can potentially be used as therapeutic agents for treating these conditions.

InChI:InChI=1/C11H11NO2/c1-2-14-11(13)9-3-4-10-8(7-9)5-6-12-10/h3-7,12H,2H2,1H3

Upstream product

• 153602-63-2 pyrano<4,3-b>pyrrol-6(1H)-one 
• 623-47-2 propynoic acid ethyl ester 
• 153602-65-4 isobutyl 6-oxopyrano<4,3-b>pyrrole-1-carboxylate 
• 10075-50-0 5-bromo-1H-indole 
• 1609-47-8 diethyl dicarbonate 
• 936840-07-2 ethyl 4-amino-3-ethynylbenzoate 
• 1034269-62-9 ethyl 4-amino-3-[2-(trimethylsilyl)ethynyl]benzoate 
• 62875-84-7 3-iodobenzocaine 
• 94-09-7 p-aminoethylbenzoate 
• 1670-81-1 1H-Indole-5-carboxylic acid 
• 64-17-5 ethanol 

Downstream Products

• 329185-67-3 1H-indole-5-(N-phenyl)carboxamide 
• 884507-16-8 5-isocyanato-1-methyl-1H-indole 
• 186129-25-9 1-methyl-1H-indole-5-carboxylic acid 
• 329185-63-9 1-(N,N-dimethylsulfamoyl)-1H-indole-5-(N-phenyl)carboxamide 
• 420783-73-9 1-(N,N-dimethylsulfamoyl)-2-trimethylsilyl-1H-indole-5-(N-phenyl)carboxamide 
• 1095885-49-6 C₁₈H₁₆N₂O₃ 
• 406192-82-3 1H-indole-5-carbohydrazide 
• 739365-22-1 1-acetyl-1H-indole-5-carboxylic acid 
• 496946-82-8 1-benzoyl-1H-indole-5-carboxylic acid 
• 118757-13-4 ethyl 1-phenylsulfonylindole-5-carboxylate 

Relevant articles and documents

Discovery and synthesis of 2-amino-1-methyl-1H-imidazol-4(5H)-ones as GPCR ligands; an approach to develop breast cancer drugs via GPCR associated PAR1 and PI3Kinase inhibition mechanism

Efforts were taken to synthesis and characterize 2-amino-1-methyl-1H-imidazole-4(5H)-one derivatives (4a-u) through a four-step reaction. The achieved compounds in remarkable yield have characterized through standard analytical techniques such as FTIR, LC

Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters

An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.

INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS

There is provided according to the invention novel compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: (I) useful as PPAR activators.