3406-75-5

Basic information

• Product Name: 2-[(4-NITROPHENYL)SULFANYL]ACETIC ACID
• Synonyms: 2-[(4-NITROPHENYL)SULFANYL]ACETIC ACID;2-[(4-NITROPHENYL)SULPHANYL]ACETIC ACID;Acetic acid, [ (4-nitrophenyl)thio]-;[(4-Nitrophenyl)sulphanyl]acetic acid, [(4-Nitrophenyl)mercapto]acetic acid;[(4-Nitrophenyl)sulphanyl]acetic acid;[(4-Nitrophenyl)thio]acetic acid, 2-[(4-Nitrophenyl)sulphanyl]ethanoic acid
• CAS NO: 3406-75-5
• Molecular Formula: C₈H₇NO₄S
• Molecular Weight: 213.21
• Mol File: 3406-75-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 155-157
• Boiling Point: 417.2 °C at 760 mmHg
• Flash Point: 206.1 °C
• Appearance: /
• Density: 1.48 g/cm³
• Vapor Pressure: 1.05E-07mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: 2-[(4-NITROPHENYL)SULFANYL]ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-NITROPHENYL)SULFANYL]ACETIC ACID(3406-75-5)
• EPA Substance Registry System: 2-[(4-NITROPHENYL)SULFANYL]ACETIC ACID(3406-75-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 3406-75-5(Hazardous Substances Data)

Usage

General Description

2-[(4-Nitrophenyl)sulfanyl]acetic acid is a chemical compound with the molecular formula C8H7NO4S. It is a white to yellow crystalline powder that is used in the preparation of various pharmaceutical compounds. The compound contains a nitro group and a thiol group, which makes it reactive and able to participate in various chemical reactions. 2-[(4-NITROPHENYL)SULFANYL]ACETIC ACID is also used as a starting material in the synthesis of other organic compounds and can be used as a building block for the development of new drugs or agrochemicals. It is important to handle this compound with care as it can be potentially hazardous if not handled properly.

InChI:InChI=1/C8H7NO4S/c10-8(11)5-14-7-3-1-6(2-4-7)9(12)13/h1-4H,5H2,(H,10,11)

Upstream product

• 68-11-1 mercaptoacetic acid 
• 100-00-5 4-chlorobenzonitrile 
• 79-11-8 chloroacetic acid 
• 1849-36-1 para-nitrobenzenethiol 
• 3926-62-3 sodium monochloroacetic acid 
• 79-08-3 bromoacetic acid 
• 97209-76-2 3-Hydroxy-3-(4-methoxy-phenyl)-2-(4-nitro-phenylsulfanyl)-propionic acid methyl ester 
• 75032-27-8 ethyl <(p-nitrophenyl)thio>acetate 
• 171414-22-5 N-Benzyl-N-(4-methoxy-benzyl)-4-nitro-benzenesulfonamide 
• 7732-18-5 water 
• 900537-28-2 N-methyl-N-(4-methoxyphenyl)-4-nitrobenzene sulphonamide 
• 900537-29-3 N-methyl-N-nosyl-o-fluoroaniline 
• 900537-33-9 N-methyl-N-nosyl-m-aminobenzonitrile 
• 900537-30-6 N-(2-iodophenyl)-N-methyl-4-nitrobenzenesulfonamide 

Downstream Products

• 3406-71-1 (4-nitrophenylsulfinyl)acetic acid 
• 3937-94-8 2-(4-nitrophenyl)sulfonylacetic acid 
• 104-18-7 2-(4-aminophenylthio)acetic acid 
• 100959-23-7 bromo-(4-nitro-phenylsulfanyl)-acetic acid 
• 16503-73-4 Dichlor-(4-nitrophenylmercapto)-acetylchlorid 
• 6625-35-0 methyl 2-(4-nitrophenylsulfanyl)acetate 
• 102582-90-1 tris(2-hydroxyethyl)ammonium 4-nitrophenylsulfanylacetate 
• 67141-29-1 2-(p-nitrophenylthiaoxy)acetyl chloride 
• 105892-18-0 2-hydroxyethylammonium 4-nitrophenylsulfanylacetate 
• 105892-19-1 (4-Nitro-phenylsulfanyl)-acetic acid; compound with 2-(2-hydroxy-ethylamino)-ethanol 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 1849-36-1 para-nitrobenzenethiol 
• 298-12-4 Glyoxilic acid 
• 21298-67-9 2,2-Di-(4-nitro-thiophenoxy)-essigsaeure 

Relevant articles and documents

Hydrogen-bonded molecular ladders in S-(4-nitrophenyl)thioglycolic acid

Hydrogen-bonded molecular ladders in S-(4-nitrophenyl)thioglycolic acid was studied. The supramolecular structure of S-(4-nitrophynl)thioglycolic acid, O2NC6H4S-CH2COOH where both C-H···O hydrogen bonds and arom

Thiopyrimidine heterocycle anti-tumor compounds as well as preparation method and application thereof

The invention relates to thiopyrimidine heterocycle anti-tumor compounds as well as a preparation method and an application thereof. The anti-tumor compounds specifically have the structure shown in aformula (I). The invention also relates to the compounds shown in the formula (I), pharmaceutically acceptable salts of the compounds or pharmaceutical composition containing the compounds. The pharmaceutical composition can treat tumor diseases by inhibiting wild type EGFR (epidermal growth factor receptor) and mutant type EGFR-T790M PTK (protein tyrosine kinase) and is particularly applied to treatment of small cell lung cancer, non-small cell lung cancer and EGFR-T790M mutant type non-small cell lung cancer.

Synthesis of thioether andrographolide derivatives and their inhibitory effect against cancer cells

A series of novel thioether andrographolide derivatives were synthesized by incorporating various aromatic (or heteroaromatic) substituents into C-12 or 14-OH. A total of 38 andrographolide derivatives were prepared and evaluated for their in vitro inhibi