370893-06-4

Basic information

• Product Name: [4-[4-[C-(4-bromophenyl)-N-ethoxy-carbonimidoyl]-1-piperidyl]-4-methyl-1-piperidyl]-(2,4-dimethyl-1-oxido-pyridin-3-yl)methanone
• Synonyms: [4-[4-[C-(4-bromophenyl)-N-ethoxy-carbonimidoyl]-1-piperidyl]-4-methyl-1-piperidyl]-(2,4-dimethyl-1-oxido-pyridin-3-yl)methanone;Ancriviroc;Ancriviroc (usan/inn);D03210
• CAS NO: 370893-06-4
• Molecular Formula: C28H37BrN4O3
• Molecular Weight: 557.52
• Mol File: 370893-06-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [4-[4-[C-(4-bromophenyl)-N-ethoxy-carbonimidoyl]-1-piperidyl]-4-methyl-1-piperidyl]-(2,4-dimethyl-1-oxido-pyridin-3-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [4-[4-[C-(4-bromophenyl)-N-ethoxy-carbonimidoyl]-1-piperidyl]-4-methyl-1-piperidyl]-(2,4-dimethyl-1-oxido-pyridin-3-yl)methanone(370893-06-4)
• EPA Substance Registry System: [4-[4-[C-(4-bromophenyl)-N-ethoxy-carbonimidoyl]-1-piperidyl]-4-methyl-1-piperidyl]-(2,4-dimethyl-1-oxido-pyridin-3-yl)methanone(370893-06-4)

Safety Data

• Hazardous Substances Data: 370893-06-4(Hazardous Substances Data)

Usage

Uses

Antiviral; treatment of autoimmune conditions (CCR5 antagonist).

Upstream product

• 372156-99-5 3-carboxy-2,4-dimethylpyridine 1-oxide 
• 515881-16-0 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1-(4-methyl-4-piperidinyl)-piperidine 
• 498-94-2 isonipecotic acid 
• 55314-30-2 2,4-dimethylnicotinic acid 
• 126501-70-0 1-(2,2,2-trifluoroacetyl)piperidine-4-carboxylic acid 
• 126501-71-1 1-(2,2,2-trifluoroacetyl)piperidine-4-carbonyl chloride 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 203186-02-1 4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-piperidine 
• 203186-01-0 1-[4-(4-bromobenzoyl)piperidin-1-yl]-2,2,2-trifluoroethanone 
• 305794-44-9 (4-bromo-phenyl)-(4'-methyl-[1,4']bipiperidinyl-4-yl)-methanone 
• 203187-77-3 1-{4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]piperidin-1-yl}-2,2,2-trifluoroethanone 
• 305794-45-0 4-(4-bromobenzoyl)-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine 
• 438207-93-3 4-[(4-bromo-phenyl)-ethoxyimino-methyl]-4'-methyl-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester 
• 305794-43-8 4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine 

Relevant articles and documents

PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS

Pharmaceutical compositions for the treatment of HIV are provided comprising compounds of formula (II) or a pharmaceutically acceptable salt or isomer thereof, in combination with specified antiviral agents.

Discovery of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl- 3pyridinyl)carbonyl]-4′-methyl-1,4′bipiperidine N-oxide (SCH 351125): An orally bioavailable human CCR5 antagonist for the treatment of HIV infection

Structure - activity studies on piperidino-piperidine 3 led to the discovery of SCH 351125 (1), a selective CCR5 antagonist with potent activity against RANTES binding (Ki=2 nM), which possesses subnanomolar activity in blocking viral entry and