372156-99-5

Basic information

• Product Name: 2,4-DIMETHYLPYRIDINE-3-CARBOXYLIC ACID N-OXIDE
• Synonyms: 2,4-DIMETHYLPYRIDINE-3-CARBOXYLIC ACID N-OXIDE;N-OXIDE-2,4-DIMETHYL-3-PYRIDINE CARBOXYLIC ACID;2,4-dimethyl-1-oxidopyridin-1-ium-3-carboxylic acid
• CAS NO: 372156-99-5
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• Mol File: 372156-99-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 436.6°Cat760mmHg
• Flash Point: 217.8°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 2.15E-08mmHg at 25°C
• Refractive Index: 1.556
• PKA: 0.90±0.34(Predicted)
• CAS DataBase Reference: 2,4-DIMETHYLPYRIDINE-3-CARBOXYLIC ACID N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHYLPYRIDINE-3-CARBOXYLIC ACID N-OXIDE(372156-99-5)
• EPA Substance Registry System: 2,4-DIMETHYLPYRIDINE-3-CARBOXYLIC ACID N-OXIDE(372156-99-5)

Safety Data

• Hazardous Substances Data: 372156-99-5(Hazardous Substances Data)

Usage

General Description

2,4-Dimethylpyridine-3-carboxylic acid N-oxide is a chemical compound with the molecular formula C8H9NO3. It is a derivative of pyridine and belongs to the class of N-oxides. 2,4-DIMETHYLPYRIDINE-3-CARBOXYLIC ACID N-OXIDE is used in the production of pharmaceuticals, agrochemicals, and other organic compounds. It has been studied for its potential biological activities, including its antibacterial and antifungal properties. Additionally, 2,4-Dimethylpyridine-3-carboxylic acid N-oxide has been investigated for its potential use in organic electronics and as a building block for the synthesis of new materials.

InChI:InChI=1/C8H9NO3/c1-5-3-4-9(12)6(2)7(5)8(10)11/h3-4H,1-2H3,(H,10,11)

Upstream product

• 55314-30-2 2,4-dimethylnicotinic acid 
• 405058-67-5 2,4-dimethyl-1-oxy-nicotinic acid ethyl ester 
• 37669-78-6 ethyl 2,4-dimethylnicotinate 

Downstream Products

• 370893-06-4 ancriviroc 
• 678975-03-6 4-({[1'-(2,4-dimethyl-1-oxy-pyridine-3-carbonyl)-4'-methyl-[1,4']bipiperidinyl-4-yl]-phenyl-amino}-methyl)-benzonitrile 
• 306293-41-4 Sch 350634 

Relevant articles and documents

Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication

A series of CCR5 antagonists were optimized for potent inhibition of R5 HIV-1 replication in peripheral blood mononuclear cells. Compounds that met acceptable ADME criteria, selectivity, human plasma protein binding, potency shift in the presence of α-glycoprotein were evaluated in rat and dog pharmacokinetics.

Discovery of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl- 3pyridinyl)carbonyl]-4′-methyl-1,4′bipiperidine N-oxide (SCH 351125): An orally bioavailable human CCR5 antagonist for the treatment of HIV infection

Structure - activity studies on piperidino-piperidine 3 led to the discovery of SCH 351125 (1), a selective CCR5 antagonist with potent activity against RANTES binding (Ki=2 nM), which possesses subnanomolar activity in blocking viral entry and