37669-78-6

Basic information

• Product Name: ETHYL 2,4-DIMETHYLPYRIDINE-3-CARBOXYLATE
• Synonyms: LABOTEST-BB LT00455664;ETHYL 2,4-DIMETHYL-3-PYRIDINECARBOXYLATE;ETHYL-2,4-DIMETHYL NICOTINATE;ETHYL 2,4-DIMETHYLPYRIDINE-3-CARBOXYLATE;2,4-DIMETHYLNICOTINIC ACID ETHYL ESTER;2,4-DIMETHYL-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER;2,4-Dimethylpyridine-3-carboxylic acid ethyl ester~Ethyl 2,4-dimethylnicotinate;ETHYL 2,4-DIMETHYLPYRIDINE-3-CARBOXYLATE 96%
• CAS NO: 37669-78-6
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Product Categories: pharmacetical
• Mol File: 37669-78-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 116-118°C 10mm
• Flash Point: 116-118°C/10mm
• Appearance: /
• Density: 1.056
• Vapor Pressure: 0.0447mmHg at 25°C
• Refractive Index: 1.4980
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.67±0.18(Predicted)
• Water Solubility: Slightly soluble in water.
• BRN: 133910
• CAS DataBase Reference: ETHYL 2,4-DIMETHYLPYRIDINE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DIMETHYLPYRIDINE-3-CARBOXYLATE(37669-78-6)
• EPA Substance Registry System: ETHYL 2,4-DIMETHYLPYRIDINE-3-CARBOXYLATE(37669-78-6)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 37669-78-6(Hazardous Substances Data)

Usage

Description

Ethyl 2,4-dimethylpyridine-3-carboxylate is an organic compound that belongs to the pyridine carboxylate family. It is characterized by the presence of a pyridine ring with two methyl groups at the 2nd and 4th positions and a carboxylate group attached to the 3rd position. Ethyl 2,4-dimethylpyridine-3-carboxylate is known for its potential applications in various fields, particularly in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
Ethyl 2,4-dimethylpyridine-3-carboxylate is used as a key intermediate in the design, synthesis, and evaluation of a family of propargyl pyridinyl ethers. These propargyl pyridinyl ethers are potential cytochrome P450 inhibitors, which play a crucial role in the metabolism of various drugs and other xenobiotics in the body. By inhibiting cytochrome P450 enzymes, these propargyl pyridinyl ethers can modulate drug metabolism and potentially improve the efficacy and safety of certain medications.
Used in Chemical Industry:
In the chemical industry, Ethyl 2,4-dimethylpyridine-3-carboxylate can be utilized as a building block or a precursor for the synthesis of various complex organic molecules and pharmaceutical compounds. Its unique structure and functional groups make it a valuable component in the development of new chemical entities with potential applications in various fields, such as agrochemicals, materials science, and specialty chemicals.

InChI:InChI=1/C10H13NO2/c1-4-13-10(12)9-7(2)5-6-11-8(9)3/h5-6H,4H2,1-3H3

Upstream product

• 52199-37-8 2,4-dimethyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 2976-86-5 1-amino-1-buten-3-one 
• 141-97-9 ethyl acetoacetate 
• 58052-80-5 2,4,6-Trimethyl-[1,3,5]triazinane; hydrate 
• 75-07-0 acetaldehyde 
• 593-67-9 vinylamine 
• 626-34-6 ethyl aminocrotonate 
• 62022-04-2 ethyl 2,4-dichloropyridine-3-carboxylate 
• 544-97-8 dimethyl zinc(II) 
• 1522-41-4 ethyl-2-fluoroacetoacetate 
• 123-73-9 crotonaldehyde 
• 14369-81-4 ethyl 2,3-butadienoate 
• 14044-63-4 but-3-yn-1-amine 

Downstream Products

• 38059-38-0 3-Acetyl-2,4-dimethylpyridin 
• 55314-30-2 2,4-dimethylnicotinic acid 
• 194151-96-7 (2,4-dimethylpyridin-3-yl)-methanol 
• 193889-74-6 4,4',6,6'-tetramethyl-5,5'-bis[(S)-(-)-1-phenylethylcarbamoyl]-2,2'-bipyridine 
• 168072-32-0 2,4-dimethyl-3-pyridinecarboxaldehyde 
• 1027913-91-2 3-[2'-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-ylmethyl]-2,4-dimethyl-pyridine 
• 1026431-90-2 [2'-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-yl]-(2,4-dimethyl-pyridin-3-yl)-methanol 
• 1027899-64-4 3-{Chloro-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-yl]-methyl}-2,4-dimethyl-pyridine 
• 405058-67-5 2,4-dimethyl-1-oxy-nicotinic acid ethyl ester 
• 871492-83-0 6-chloro-N-(R)-{3-[4-(4-methoxy-phenylamino)-piperidin-1-yl]-butyl}-2,4-dimethyl-nicotinamide 
• 372156-99-5 3-carboxy-2,4-dimethylpyridine 1-oxide 
• 1421928-62-2 methyl 2-(4-((2,4-dimethylpyridin-3-yl)methoxy)phenyl)acetate 
• 588729-46-8 (2,4-dimethylpyridin-3-yl)methanamine 
• 1687855-47-5 ethyl 2-(chloromethyl)-4-methylnicotinate 

Relevant articles and documents

Synthesis of 3-Keto Pyridines from the Conjugated Allenone – Alkynylamine Oxidative Cyclization Catalyzed by Supported Au Nanoparticles

Recyclable supported Au nanoparticles on TiO2 catalyze the cyclization of N-propargyl or N-homopropargyl β-enaminones followed by dehydrogenation (aromatization) leading to substituted 3-keto pyridines or 4-picolines in very good yields. This pathway is in contrast to their known cyclization in the presence of Au(I) or Au(III) catalysts which provides 1,4-oxazepines, instead. The enaminones are formed in situ upon mixing a conjugated allenone or allenyl ester with the alkynylamine, thus the pyridine-forming transformation is typically a one pot process. (Figure presented.).

METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS

The present invention relates to pyrimidine derivatives of Formula (Ia) and (Ib) (including tautomers, isomers, prodrugs, and pharmaceutically acceptable salts thereof). Said compounds are useful in the treatment of pain (such as neuropathic pain), inflammation, and epilepsy (by acting as anticonvulsants). Methods of medical treatment making use of said compounds, as well as additional compounds of Formula (IIa) and (IIb), are also disclosed.

Nonpeptide angiotensin II receptor antagonists. I. Synthesis and biological activity of pyridine derivatives

Substituted pyridines were synthesized as potential angiotensin II (AII) receptor antagonists. Substitution at the position 2 in the pyridine resulted in potent activity, and the optimal alkyl length was four carbons. The potency further increased with the introduction of a hydroxymethyl group at the position 4. One of the compounds, 2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-[[2'-(1H-tetrazol-5-yl)bip henyl-4-yl]methyl]pyridine 9 h (KT3-579)is a competitive AII antagonist with a pA2 value of 9.31, and is about 10 times more potent than Du Pont 753. It was found to be an AT1 specific antagonist with an IC50 of 3.09 nM.