52199-37-8

Basic information

• Product Name: 2,4-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2,4-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER;3-ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine
• CAS NO: 52199-37-8
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.2316
• Mol File: 52199-37-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 269.4°Cat760mmHg
• Flash Point: 116.7°C
• Appearance: /
• Density: 1.011g/cm³
• Vapor Pressure: 0.00728mmHg at 25°C
• Refractive Index: 1.476
• CAS DataBase Reference: 2,4-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(52199-37-8)
• EPA Substance Registry System: 2,4-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(52199-37-8)

Safety Data

• Hazardous Substances Data: 52199-37-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 3413, 1984 DOI: 10.1021/jo00192a043

InChI:InChI=1/C10H15NO2/c1-4-13-10(12)9-7(2)5-6-11-8(9)3/h5-7,11H,4H2,1-3H3

Upstream product

• 110-89-4 piperidine 
• 123-73-9 trans-Crotonaldehyde 
• 64-17-5 ethanol 
• 626-34-6 ethyl aminocrotonate 
• 139943-10-5 N,N-dimethyl-1,3-butadien-1-amine 
• 123-73-9 crotonaldehyde 

Downstream Products

• 37669-78-6 ethyl 2,4-dimethylnicotinate 
• 102810-89-9 5-(2,4-dinitro-phenylhydrazono)-2-[1-(2,4-dinitro-phenylhydrazono)-ethyl]-3-methyl-valeric acid ethyl ester 
• 168072-32-0 2,4-dimethyl-3-pyridinecarboxaldehyde 
• 194151-96-7 (2,4-dimethylpyridin-3-yl)-methanol 
• 1027913-91-2 3-[2'-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-ylmethyl]-2,4-dimethyl-pyridine 
• 1026431-90-2 [2'-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-yl]-(2,4-dimethyl-pyridin-3-yl)-methanol 
• 1027899-64-4 3-{Chloro-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-yl]-methyl}-2,4-dimethyl-pyridine 
• 55314-30-2 2,4-dimethylnicotinic acid 

Relevant articles and documents

Nonpeptide angiotensin II receptor antagonists. I. Synthesis and biological activity of pyridine derivatives

Substituted pyridines were synthesized as potential angiotensin II (AII) receptor antagonists. Substitution at the position 2 in the pyridine resulted in potent activity, and the optimal alkyl length was four carbons. The potency further increased with the introduction of a hydroxymethyl group at the position 4. One of the compounds, 2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-[[2'-(1H-tetrazol-5-yl)bip henyl-4-yl]methyl]pyridine 9 h (KT3-579)is a competitive AII antagonist with a pA2 value of 9.31, and is about 10 times more potent than Du Pont 753. It was found to be an AT1 specific antagonist with an IC50 of 3.09 nM.