485841-47-2

Basic information

• Product Name: 2-Pyridinecarboxamide, 4-[3-amino-4-(methylamino)phenoxy]-N-methyl-
• CAS NO: 485841-47-2
• Molecular Formula: C14H16N4O2
• Molecular Weight: 272.307
• Mol File: 485841-47-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pyridinecarboxamide, 4-[3-amino-4-(methylamino)phenoxy]-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxamide, 4-[3-amino-4-(methylamino)phenoxy]-N-methyl-(485841-47-2)
• EPA Substance Registry System: 2-Pyridinecarboxamide, 4-[3-amino-4-(methylamino)phenoxy]-N-methyl-(485841-47-2)

Safety Data

• Hazardous Substances Data: 485841-47-2(Hazardous Substances Data)

Upstream product

• 220000-87-3 4-chloro-N-methylpicolinamide 
• 610-81-1 4-hydroxy-2-nitroaniline 
• 485841-45-0 4-(4-amino-3-nitro-phenoxy)-pyridine-2-carboxylic acid methylamide 
• 485841-46-1 4-(4-methylamino-3-nitrophenoxy)-pyridine-2-carboxylic acid methylamide 

Downstream Products

• 611213-97-9 4-({1-methyl-5-[2-(N-methylcarbamoyl)(4-pyridyloxy)]benzimidazol-2-yl}amino)benzoic acid 
• 611214-71-2 3-{[1-methyl-5-({2-[(methylamino)carbonyl]pyridin-4-yl}-oxy)-1H-benzimidazol-2-yl]amino}benzoic acid 
• 611225-83-3 [4-(2-{[4-(chloromethyl)phenyl]carbonylamino}-1-methylbenzimidazol-5-yloxy)(2-pyridyl)]-N-methylcarboxamide 
• 611214-36-9 4-({2-[(4-fluorophenyl)amino]-1-methyl-1H-benzimidazol-5-yl}oxy)-N-methylpyridine-2-carboxamide 
• 611213-93-5 (4-{2-[(3,4-difluorophenyl)-amino]-1-methylbenzimidazol-5-yloxy}(2-pyridyl))-N-methylcarboxamide 
• 611214-21-2 (4-{2-[(2-fluorophenyl)amino]-1-methylbenzimidazol-5-yloxy}-(2-pyridyl))-N-methylcarboxamide 
• 611214-15-4 (4-{2-[(4-cyanophenyl)amino]-1-methylbenzimidazol-5-yloxy}-(2-pyridyl))-N-methylcarboxamide 
• 611213-96-8 (4-{2-[(3-fluorophenyl)amino]-1-methylbenzimidazol-5-yloxy}-(2-pyridyl))-N-methylcarboxamide 
• 611214-77-8 4-({2-[(2,3-difluorophenyl)amino]-1-methyl-1H-benzimidazol-5-yl}oxy)-N-methylpyridine-2-carboxamide 
• 611213-70-8 4-[2-(4-bromophenylamino)-1-methyl-1H-benzimidazol-5-yloxy]pyridine-2-carboxylic acid 
• 611213-71-9 4-[(2-{[4-chloro-3-(trifluoromethyl)phenyl]amino}-1-methyl-1H-benzimidazol-5-yl)-oxy]-N-methylpyridine-2-carboxamide 
• 611214-16-5 N-methyl[4-(1-methyl-2-{[3-(trifluoromethyl)phenyl]amino}-benzimidazol-5-yloxy)(2-pyridyl)]carboxamide 
• 611214-42-7 4-{[2-(cyclohexylamino)-1-methyl-1H-benzimidazol-5-yl]-oxy}-N-methylpyridine-2-carboxamide 

Relevant articles and documents

Design and synthesis of orally bioavailable benzimidazoles as raf kinase inhibitors

A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure-activity relationship resulted in compounds that are potent in vitro and show desirable in vivo properties.

Substituted benzazoles and methods of their use as inhibitors of Raf kinase

New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.