502761-26-4Relevant articles and documents
Cyanopeptide analogues: New lead structures for the design and synthesis of new thrombin inhibitors
Radau, Gregor,Stuerzebecher
, p. 729 - 732 (2007/10/03)
This contribution deals with the structure-based design and syntheses of the new serine protease inhibitors RA-1001 and RA-1002, which are analogues of the blue-green algae derived cyanopeptide aeruginosin 98-B. Both compounds inhibit thrombin with Ki values of 5.6 μM and 8.7 μM, respectively.