658053-31-7

Basic information

• Product Name: L-Proline, N-[3-(4-hydroxyphenyl)-1-oxopropyl]-L-isoleucyl-
• CAS NO: 658053-31-7
• Molecular Formula: C20H28N2O5
• Molecular Weight: 376.453
• Mol File: 658053-31-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Proline, N-[3-(4-hydroxyphenyl)-1-oxopropyl]-L-isoleucyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, N-[3-(4-hydroxyphenyl)-1-oxopropyl]-L-isoleucyl-(658053-31-7)
• EPA Substance Registry System: L-Proline, N-[3-(4-hydroxyphenyl)-1-oxopropyl]-L-isoleucyl-(658053-31-7)

Safety Data

• Hazardous Substances Data: 658053-31-7(Hazardous Substances Data)

Upstream product

• 275801-69-9 N-[3-(4-hydroxyphenyl)propionyl]-L-isoleucine 
• 54793-61-2 L-isoleucyl-L-proline methyl ester 
• 68856-94-0 (S)-methyl 1-((2S,3S)-2(tert-butoxycarbonylamino)-3-mehylpentanoyl)pyrrolidine-2-carboxylate 
• 501-97-3 4-hydroxyphenylpropionic acid 
• 34071-95-9 N-succinimidyl-3-(p-hydroxyphenyl)propionate 
• 502761-23-1 N-[3-(4-hydroxyphenyl)propionyl]-L-isoleucyl-L-proline methyl ester 

Downstream Products

• 502761-26-4 RA-1003 
• 658053-32-8 N-[3-(4-hydroxyphenyl)propionyl]-L-isoleucyl-L-proline 2-[4-(tert-butyloxycarbonyl)piperazin-1-yl]ethyl ester 
• 502761-25-3 1-tert-butoxycarbonylamino-4-{N-[3-(4-hydroxyphenyl)propionyl]-L-isoleucyl-L-prolylamino}butane 

Relevant articles and documents

New cyanopeptide-derived low molecular weight thrombin inhibitors

Thrombosis is the result of defective regulation of the hemostasis system. This cardiovascular disorder may lead to deep vein thrombosis, myocardial infarction, and stroke. The majority of current drug research is focused on finding inhibitors of thrombin - the global player in hemostasis. In our work, we emphasize investigation of the marine environment to yield new lead structures from marine organisms like blue-green algae (cyanobacteria). This article deals with the design, syntheses, and inhibition tests of new low molecular weight thrombin inhibitors utilizing cyanopeptides, the secondary metabolites of cyanobacteria with interesting biological activities, as new lead structures. Starting with aeruginosin 98-B (2) as a lead structure, we have developed and synthesized new, selective acting inhibitors of thrombin (RA-1001 and RA-1002), which are suitable targets for further structure-activity studies.