63593-03-3Relevant articles and documents
Synthesis method of 3-O-benzyl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose
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, (2021/07/01)
The invention provides a synthesis method of 3-O-benzyl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose. The synthesis method comprises the following steps: reacting glucose with acetone to obtain a first intermediate product; carrying out oxidation reaction on the first intermediate product through N-bromosuccinimide to obtain a second intermediate product; carrying out reduction reaction on the second intermediate product through sodium borohydride to obtain a third intermediate product; reacting benzyl chloride with the third intermediate product to obtain a fourth intermediate product; reacting the fourth intermediate product with an acidic solution to obtain a fifth intermediate product; and carrying out oxidation reaction and disproportionation reaction on the fifth intermediate product to obtain the 3-O-benzyl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose. The 3-O-benzyl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose is synthesized by taking the glucose with low price as a raw material through six steps.
NOVEL PROCESS FOR MAKING ALLOFURANOSE FROM GLUCOFURANOSE
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, (2019/12/15)
The present invention relates to the manufacture of allofuranose from glucofuranose as defined in the description and in the claim. Allofuranos is an intermediate in the manufacture of oligonucleotides which can be used as a medicament.
SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
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, (2016/03/11)
Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.