72571-06-3

Basic information

• Product Name: 5-(4-BROMOPHENYL)-1,3-OXAZOLE
• Synonyms: 5-(4-BROMOPHENYL)-1,3-OXAZOLE;5-(4-BROMOPHENYL)OXAZOLE;1-Bromo-4-(1,3-oxazol-5-yl)benzene
• CAS NO: 72571-06-3
• Molecular Formula: C₉H₆BrNO
• Molecular Weight: 224.05
• Product Categories: Halides;Heterocycles
• Mol File: 72571-06-3.mol
• Article Data: 18

Chemical Properties

• Melting Point: 78-80°C
• Boiling Point: 315.8 °C at 760 mmHg
• Flash Point: 144.8 °C
• Appearance: /
• Density: 1.524 g/cm³
• Vapor Pressure: 0.000794mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 5-(4-BROMOPHENYL)-1,3-OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-BROMOPHENYL)-1,3-OXAZOLE(72571-06-3)
• EPA Substance Registry System: 5-(4-BROMOPHENYL)-1,3-OXAZOLE(72571-06-3)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 72571-06-3(Hazardous Substances Data)

Usage

General Description

5-(4-Bromophenyl)-1,3-oxazole is a chemical compound with the molecular formula C9H6BrNO. It is a heterocyclic compound containing a five-membered oxazole ring with a bromophenyl substituent. 5-(4-BROMOPHENYL)-1,3-OXAZOLE is commonly used in pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active compounds such as medicinal drugs and pesticides. It is also utilized in chemical research and development processes for the creation of new chemical entities and materials. The presence of the bromine atom in the phenyl ring provides unique chemical and physical properties to this compound, making it a valuable intermediate in organic synthesis.

InChI:InChI=1/C9H6BrNO/c10-8-3-1-7(2-4-8)9-5-11-6-12-9/h1-6H

Upstream product

• 5467-72-1 α-amino-4-bromoacetophenone hydrochloride 
• 122-51-0 orthoformic acid triethyl ester 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 1122-91-4 4-bromo-benzaldehyde 
• 72571-05-2 ethyl 5-(4-bromophenyl)oxazole-2-carboxylate 
• 77287-34-4 formamide 
• 99-73-0 para-bromophenacyl bromide 
• 55605-27-1 (4-bromophenyl)methylenediacetate 
• 68-12-2 N,N-dimethyl-formamide 
• 873-75-6 4-bromobenzenemethanol 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 7099-87-8 4-bromophenylglyoxylic acid 
• 72571-04-1 ethyl [[2-(4-bromophenyl)-2-oxoethyl]amino]oxoacetate 

Downstream Products

• 282117-22-0 5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxazole 
• 859536-72-4 1-(2-(6-(4-oxazol-5-yl-phenoxy)-2-pyridin-2-yl-3-(2-trimethylsilanyl-ethoxymethyl)-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone 
• 929918-42-3 (R)-2-[4-(4-Oxazol-5-yl-phenoxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1021919-20-9 5-(4-(trimethylstannyl)phenyl)oxazole 
• 96908-21-3 2-phenyl-5-(4-bromophenyl)-5-oxazole 
• 1170659-61-6 methyl 4-(5-(4-bromophenyl)oxazol-2-yl)benzoate 
• 1283595-57-2 2-(benzothiazol-2-yl)-5-(4-bromophenyl)oxazole 
• 4271-09-4 2,2'-benzothiazolyl 
• 1395681-39-6 5-(4-bromophenyl)-2-(4,5-dimethylthiazol-2-yl)oxazole 
• 3944-30-7 4,4’,5,5’-tetramethyl-2,2’-bithiazole 
• 1445218-27-8 4-(4-bromophenyl)-6,7-dihydro-5H-cyclopenta[c]pyridine 
• 1552273-99-0 5-(4-bromophenyl)-1-cyclopentyl-1H-imidazole 
• 1552274-14-2 5-(4-bromophenyl)-1-[2-(4-fluorophenyl)ethyl]-1H-imidazole 
• 1552274-28-8 1-cyclopropylmethyl-5-(4-bromophenyl)-1H-imidazole 

Relevant articles and documents

INHIBITOR COMPOUNDS

The disclosure relates to heterocyclic compounds and methods for their preparation. The disclosure provides compounds that may have beneficial therapeutic activity in the treatment of a disease or condition mediated by excessive or otherwise undesirable Des1 and/or fibrotic activity.

Libraries of C-5 Substituted Imidazoles and Oxazoles by Sequential Van Leusen (VL)–Suzuki, VL–Heck and VL–Sonogashira in Imidazolium-ILs with Piperidine-Appended-IL as Base

Facile access to diverse C5-substituted imidazoles and oxazoles via sequential Van Leusen–Suzuki, Van Leusen–Heck, and Van Leusen–Sonogashira protocols, employing imidazolium-ILs as solvents along with piperidine-appended imidazolium [PAIM][NTf2/sub

A One-Pot Tandem Approach for the Synthesis of 5-(Het)aryloxazoles from Substituted (Het)aryl Methyl Alcohols and Benzyl Bromides

A new modified van Leusen strategy has been developed for the synthesis of biologically significant 5-substituted oxazoles by the reaction of (het)aryl methyl alcohols or benzyl bromides as precursors with tosylmethylisocyanide (TosMIC) under basic conditions. This method is efficient, takes place under mild reaction conditions, and is tolerant of various functional groups with high yield.