74273-47-5

Basic information

• Product Name: Benzeneacetic acid, a-aMino-4-Methoxy-, Methyl ester
• Synonyms: Benzeneacetic acid, a-aMino-4-Methoxy-, Methyl ester;5-(BroMoMethyl)-1-Methylcyclopent-1-ene;Methyl 2-aMino-2-(4-Methoxyphenyl)acetate hcl;methyl 2-amino-2-(4-methoxyphenyl)acetate hydrochloride
• CAS NO: 74273-47-5
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.21512
• Mol File: 74273-47-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 183～186℃
• Appearance: /
• CAS DataBase Reference: Benzeneacetic acid, a-aMino-4-Methoxy-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-aMino-4-Methoxy-, Methyl ester(74273-47-5)
• EPA Substance Registry System: Benzeneacetic acid, a-aMino-4-Methoxy-, Methyl ester(74273-47-5)

Safety Data

• Hazardous Substances Data: 74273-47-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 104-47-2 p-methoxybenzylnitrile 
• 2540-53-6 2-(4-methoxyphenyl)glycine 
• 32766-61-3 4-methoxyphenylglyoxylate methyl ester 
• 1076-95-5 p-methoxyphenylglyoxal 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 13226-99-8 amino(3-chloro-4-methoxyphenyl)acetic acid methyl ester hydrochloride 
• 104-01-8 4-Methoxyphenylacetic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 2540-53-6 2-(4-methoxyphenyl)glycine 
• 24593-48-4 (2S)-2-amino-2-(4-methoxyphenyl)acetic acid 
• 24593-49-5 D-(-)-2-(4-methoxyphenyl)glycine 
• 475475-37-7 [formyl-(2-{[methoxycarbonyl-(4-methoxy-phenyl)-methyl]-amino}-ethyl)-amino]-(2-methoxy-phenyl)-acetic acid methyl ester 
• 532986-34-8 N-[2-hydroxy-1-(4-methoxyphenyl)ethyl]octanamide 
• 76986-15-7 2-amino-2-(4-methoxyphenyl)acetamide 
• 1227294-10-1 (2S,3S,3aS,9bS)-3-ethyl-2-methyl-2-(4-methoxyphenyl)-1,2,3,3a,4,9b-hexahydrochromeno[4,3-b]pyrrole-2,3-dicarboxylate 
• 1423136-76-8 methyl 4-benzoyl-2-(4-methoxyphenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate 
• 1423136-77-9 methyl 4-benzoyl-2-(4-methoxyphenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate 
• 1356585-03-9 2,4-bis(4-methoxyphenyl)oxazol-5(4H)-one 

Relevant articles and documents

Catalytic Aerobic Cross-Dehydrogenative Coupling of Azlactones en Route to α,α-Disubstituted α-Amino Acids

We developed a catalytic aerobic method to synthesize α,α-disubstituted α-amino acids through cross-dehydrogenative coupling of azlactones. Combining an iron catalyst with a bisoxazolidine ligand resulted in high catalytic performance, and cross-coupling with an indole proceeded smoothly under aerobic conditions. A wide variety of α-aryl and aliphatic amino acid derived azlactones were applied to the present catalysis. In addition, a quaternary carbon could be constructed using oxindole and benzofuranone under aerobic conditions.

Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer

A new strategy, a transient homocoupling dimer strategy, for direct catalytic oxidative cross-enolate coupling reactions is developed. Cross-enolate coupling products bearing a (contiguous) tetrasubstituted carbon center were obtained chemoselectively without the need for stoichiometric amounts of strong bases/metal oxidants, and thus, the present catalysis provides a general method for the synthesis of unnatural α,α-disubstituted amino acid motifs. The distinct transformation of azlactone and 2-acylimidazole units highlighted the synthetic utility of the present catalysis.

Rh-catalyzed asymmetric hydrogenation of racemic aldimines via dynamic kinetic resolution

Catalyzed by a rhodium complex of P-stereogenic diphosphine ligand trichickenfootphos (TCFP), asymmetric hydrogenation of racemic aldimines via dynamic kinetic resolution has been realized for the preparation of chiral arylglycines with good yields and enantioselectivities.