82544-13-6Relevant articles and documents
Process for the preparation of Drospirenone
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Page/Page column 7; 9; 28, (2009/02/10)
A process for the preparation of Drospirenone (I) according to the following scheme wherein the substituent R is defined in the description. The process improves the product yield and purity by reducing the formation of undesired side-products and is particularly convenient for industrial-scale manufacturing.
Process for preparing 3β,7β-dihydroxy-Δ5 -steroids
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, (2008/06/13)
A process for preparing a 3β,7β-dihydroxy-Δ5 steroid of the formula STR1 wherein Q is STR2 and R1 is hydrogen, trimethylacetyl, tert-butyldimethylsilyl, dimethyl-2-(3-methylbutyl)silyl or tribenzylsilyl, comprises fermenting a 3β-hydroxy-Δ5 -steroid of the formula STR3 wherein Q is as defined above, and R2 is hydrogen or alkanoyl of 2-6 carbon atoms, with a culture of Botryodiplodia malorum to obtain the corresponding 3β,7β-dihydroxy-Δ5 -steroid; and, optionally, reacting the resultant product with trimethylacetic anhydride, tert-butyldimethylsilyl chloride, dimethyl-2-(3-methylbutyl)silyl chloride, or tribenzylsilyl chloride.
