82543-09-7

Basic information

• Product Name: 3H-Cycloprop[15,16]androsta-5,15-dien-17-one,3-(2,2-dimethyl-1-
• Synonyms: 3H-Cycloprop[15,16]androsta-5,15-dien-17-one,3-(2,2-dimethyl-1-;7β-hydroxy-15β,16β-Methylen-3β-pivaloyloxy-5-androsten-17-one(Q0);(3β,7β,15α,16α)-3-(2,2-DiMethyl-1-oxopropoxy)-15,16-dihydro-7-hydroxy-3'H-cycloprop[15,16]androsta-5,15-dien-17-one;7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5-androsten-17-one(Q0);7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-androst-5-en-17-one;MLROWSBVFNKEEF-UZXCHYPJSA-N
• CAS NO: 82543-09-7
• Molecular Formula: C₂₅H₃₆O₄
• Molecular Weight: 400.55094
• Product Categories: STEROID;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 82543-09-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 515.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• PKA: 13.95±0.70(Predicted)
• CAS DataBase Reference: 3H-Cycloprop[15,16]androsta-5,15-dien-17-one,3-(2,2-dimethyl-1-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Cycloprop[15,16]androsta-5,15-dien-17-one,3-(2,2-dimethyl-1-(82543-09-7)
• EPA Substance Registry System: 3H-Cycloprop[15,16]androsta-5,15-dien-17-one,3-(2,2-dimethyl-1-(82543-09-7)

Safety Data

• Hazardous Substances Data: 82543-09-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Crystalline Solid

Uses

Drospirenone intermediate.

Upstream product

• 1774-47-6 trimethylsulfoxonium iodide 
• 85390-94-9 7β-hydroxy-3β,15α-dipivaloyloxy-5-androsten-17-one 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 82543-07-5 3β,7β-dihydroxy-15β,16β-methylene-5-androsten-17-one 
• 53-43-0 dehydroepiandrosterone 
• 67372-65-0 3β-hydorxy-15β,16β-methylene androst-5-ene-17-one 
• 85390-92-7 C₂₂H₃₂O₄ 
• 2963-69-1 3β,7α,15α-trihydroxy-5-androstene-17-one 
• 85390-93-8 3β,7β,15α-trihydroxy-5-androsten-17-one 

Downstream Products

• 82544-13-6 5,6β-epoxy-7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one 
• 90457-65-1 dihydrospirorenone 
• 82543-18-8 17α-(3-hydroxypropyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol 
• 82543-16-6 (2S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR,9bR)-2,9b-dihydroxy-4a,6a-dimethyloctadecahydro-7H-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-7-one 
• 82543-15-5 3β,5-dihydroxy-15β,16β-methylene-5β-androst-6-en-17-one 
• 82543-17-7 17α-(3-hydroxy-1-propinyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol 
• 74220-07-8 Spirorenone 
• 82543-14-4 5-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androst-6-en-17-one 
• 82543-13-3 7α-chloro-5,6β-epoxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one 

Relevant articles and documents

Process for preparing 3β,7β-dihydroxy-Δ5 -steroids

A process for preparing a 3β,7β-dihydroxy-Δ5 steroid of the formula STR1 wherein Q is STR2 and R1 is hydrogen, trimethylacetyl, tert-butyldimethylsilyl, dimethyl-2-(3-methylbutyl)silyl or tribenzylsilyl, comprises fermenting a 3β-hydroxy-Δ5 -steroid of the formula STR3 wherein Q is as defined above, and R2 is hydrogen or alkanoyl of 2-6 carbon atoms, with a culture of Botryodiplodia malorum to obtain the corresponding 3β,7β-dihydroxy-Δ5 -steroid; and, optionally, reacting the resultant product with trimethylacetic anhydride, tert-butyldimethylsilyl chloride, dimethyl-2-(3-methylbutyl)silyl chloride, or tribenzylsilyl chloride.

Synthese von Spirorenon, einem neuen stark wirksamen Aldosteron-Antagonisten

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