(1S,2S)-trans-2-Aminocyclopentanol hydrochloride supplier

Name
(1S,2S)-trans-2-Aminocyclopentanol hydrochloride
EINECS
CAS No. 68327-04-8
Article Data6
CAS DataBase
Density
Solubility
Melting Point
Formula C₅H₁₁NO^.HCl
Boiling Point 220.9 °C at 760 mmHg
Molecular Weight 137.609
Flash Point 87.4 °C
Transport Information
Appearance
Safety 26-37
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms Cyclopentanol,2-amino-, hydrochloride, (1S,2S)- (9CI);Cyclopentanol, 2-amino-,hydrochloride, (1S-trans)-;(1S,2S)-2-Aminocyclopentanol hydrochloride;
PSA 46.25000
LogP 1.36080

Synthetic route

: (1R,2R)-2-acetamidocyclopentanol acetate

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride for 3h; Hydrolysis; Heating;	97%

: (1S,2S)-2-(benzyloxy)cyclopentanamine

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In methanol at 20℃; under 2068.65 Torr; for 24h;	93%

: 930-45-0, 33092-86-3, 33092-90-9, 57070-95-8, 59260-76-3, 68327-03-7, 89381-13-5, 135969-63-0
(1S,2S)-2-aminocyclopentanol

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; ethanol Yield given;

: 221110-46-9
1-azido-2-(trimethylsilyloxy)cyclopentane

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) TFA, 2.) H2 / 2.) PtO2 / 1) MeOH, rt, 30 min; 2) MeOH, rt, 40 h 2: HCl / ethanol; diethyl ether View Scheme

: 1428988-52-6
17-(5-fluoropyridin-3-yl)oestra-1,3,5(10),16-tetraene-3-carboxylic acid

: 11β-fluoro-17-(5-fluoropyridin-3-yl)-N-(2-sulphamoylethyl)oestra-1,3,5(10),16-tetraene-3-carboxamide

A: 17-(5-fluoropyridin-3-yl)-N-[(1S,2S)-2-hydroxycyclopentyl]oestra-1,3,5(10),16-tetraene-3-carboxamide

B: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

...Expand

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 123843-67-4
4-bromo-2,6-difluorobenzonitrile

: 1073973-68-8
4-bromo-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzonitrile

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 120℃; for 2h;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 145106-43-0
(1S,2S)-trans-2-(tert-butoxycarbonylamino)cyclopentanol

Conditions

Conditions	Yield
With triethylamine In methanol for 22h;	97.76%
With potassium carbonate In tetrahydrofuran; water at 20℃; for 0.75h;	7.21 g
With triethylamine In methanol at 0 - 20℃;	2.87 g
With triethylamine In methanol Inert atmosphere;

: 108-24-7
acetic anhydride

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 137254-02-5
(S,S)-trans-2-acetamidocyclopentanol

Conditions

Conditions	Yield
With sodium carbonate In acetone 1) 0 deg C --> rt, 1 h; 2) rt, 2 h;	95%

: 141-75-3
butyryl chloride

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: (1S,2S)-N-(2-hydroxycyclopentyl)butyramide

Conditions

Conditions	Yield
With sodium carbonate In dichloromethane at 20℃; for 1h;	87%

: 1073973-06-4
4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-2,6-difluoro-benzonitrile

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(trans-4-hydroxycyclohexylamino)benzamide

Conditions

Conditions	Yield
Stage #1: 4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-2,6-difluoro-benzonitrile; (1S,2S)-2-aminocyclopentanol hydrochloride With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 50℃; for 1h; Stage #2: With sodium hydroxide; water; dihydrogen peroxide In methanol; dimethyl sulfoxide at 50℃; for 1h;	85.1%

: C22H27Cl2N8O3(1-)*Li(1+)

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: C27H37Cl2N9O3

Conditions

Conditions	Yield
With dmap; HATU In N,N-dimethyl-formamide at 20℃; for 20h;	83%

: 500860-54-8
2,6-dichloro-N4,N8-dimethyl-pyrimido[5,4-d]pyrimidine-4,8-diamine

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: (1S,2S)-2-((6-chloro-4,8-bis(methylamino)pyrimido[5,4-d]pyrimidin-2-yl)amino)cyclopentanol

Conditions

Conditions	Yield
In butan-1-ol	83%

: 85-44-9
phthalic anhydride

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 223761-82-8
2-((1S,2S)-2-hydroxycyclopentyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
Stage #1: (1S,2S)-2-aminocyclopentanol hydrochloride With triethylamine In toluene at 20℃; for 0.0833333h; Stage #2: phthalic anhydride for 4h; Reflux;	73.5%

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 1403863-98-8
ethyl 4-((1S,2S)-2-hydroxycyclopentylamino)-2-(methylthio)-pyrimidine-5-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethanol at 60℃; for 15h;	73%

: 1310875-94-5
4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic acid

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 1310876-01-7
(1S,2S)-4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-N-(2-hydroxycyclopentyl)-4-oxobut-2-enamide

Conditions

Conditions	Yield
Stage #1: 4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 0.5h; Stage #2: (1S,2S)-2-aminocyclopentanol hydrochloride With sodium hydrogencarbonate In N,N-dimethyl-formamide at 0 - 5℃; for 2h;	66%

: 4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic acid

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 1445953-99-0
(1S,2S)-4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-4-hydroxy-N-(2-hydroxycyclopentyl)-2-oxobut-3-enamide

Conditions

Conditions	Yield
Stage #1: 4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 0.5h; Cooling; Stage #2: (1S,2S)-2-aminocyclopentanol hydrochloride With sodium hydrogencarbonate In N,N-dimethyl-formamide at 0 - 5℃; for 2h;	66%

: 6-((3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxy)methyl)nicotinic acid

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: N-((1S,2S)-2-hydroxycyclopentyl)-6-(((3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)oxy)methyl)nicotinamide

Conditions

Conditions	Yield
Stage #1: 6-((3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxy)methyl)nicotinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: (1S,2S)-2-aminocyclopentanol hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h;	65.8%

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 821801-03-0
2,2-difluoro-3-hydroxydodecanoic acid

: 821801-05-2
2,2-Difluoro-3-hydroxy-dodecanoic acid ((1S,2S)-2-hydroxy-cyclopentyl)-amide

Conditions

Conditions	Yield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;	65%

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 75321-89-0
2-(3-fluorophenyl)acetaldehyde

: (+/-)-tert-butyl 3-((2'-[tert-butoxycarbonyl(3''-fluorophenethyl)amino]ethyl)(methyl)amino)-4-([6'-(tert-butoxycarbonylamino)-4'-methylpyridin-2'-yl]methyl)-pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: (1S,2S)-2-aminocyclopentanol hydrochloride With triethylamine In 1,2-dichloro-ethane at 20℃; for 0.166667h; Molecular sieves 3 Å; Stage #2: 2-(3-fluorophenyl)acetaldehyde With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; Product distribution / selectivity;	62%

: 67-56-1
methanol

: 1073973-06-4
4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-2,6-difluoro-benzonitrile

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

A: 1073969-37-5
4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide

B: 1073969-71-7
4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)-6-methoxybenzamide

Conditions

Conditions	Yield
Stage #1: 4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-2,6-difluoro-benzonitrile; (1S,2S)-2-aminocyclopentanol hydrochloride With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 50℃; for 18h; Stage #2: With sodium hydroxide; water; dihydrogen peroxide In dimethyl sulfoxide at 50℃; for 2h; Stage #3: methanol With sodium hydroxide; dihydrogen peroxide In dimethyl sulfoxide at 70℃; for 1h;	A 51% B 8%

Yield

Stage #1: 4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-2,6-difluoro-benzonitrile; (1S,2S)-2-aminocyclopentanol hydrochloride With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 50℃; for 18h;
Stage #2: With sodium hydroxide; water; dihydrogen peroxide In dimethyl sulfoxide at 50℃; for 2h;
Stage #3: methanol With sodium hydroxide; dihydrogen peroxide In dimethyl sulfoxide at 70℃; for 1h;

A 51%
B 8%

...Expand

: 3-oxo-2-(pyridin-3-yl)-6-[4-(trifluoromethyl)phenyl]-2,3-dihydropyridazine-4-carboxylic acid

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: N-[(1S,2S)-2-hydroxycyclopentyl]-3-oxo-2-(pyridin-3-yl)-6-[4-(trifluoromethyl)phenyl]-2,3-dihydropyridazine-4-carboxamide

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h;	36%

: 1073973-06-4
4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-2,6-difluoro-benzonitrile

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 1073969-37-5
4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide

Conditions

Conditions	Yield
Stage #1: 4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-2,6-difluoro-benzonitrile; (1S,2S)-2-aminocyclopentanol hydrochloride With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 50℃; Stage #2: With sodium hydroxide; water; dihydrogen peroxide In methanol; dimethyl sulfoxide at 50℃;	28%

: 1414773-00-4
6-chloro-3-(4-methoxyfuro[3,2-c]pyridin-2-yl)imidazo[1,2-b]pyridazine

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 1443499-98-6
(1S,2S)-2-{[3-(4-methoxyfuro[3,2-c]pyridin-2-yl)imidazo[1,2-b]pyridazin-6-yl]-oxy}cyclopentanamine

Conditions

Conditions	Yield
Stage #1: (1S,2S)-2-aminocyclopentanol hydrochloride With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 5℃; for 0.0833333h; Cooling with ice; Stage #2: 6-chloro-3-(4-methoxyfuro[3,2-c]pyridin-2-yl)imidazo[1,2-b]pyridazine In N,N-dimethyl-formamide; mineral oil at 20℃; for 3h;	23%

: 1414772-61-4
3-(1-benzofuran-2-yl)-6-chloroimidazo[1,2-b]pyridazine

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 1610454-10-8
(1S,2S)-2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclopentanol

Conditions

Conditions	Yield
With sodium hydrogencarbonate In butan-1-ol at 150℃; for 72h;	16%

: 5987-73-5
2',3',5'-O-triacetyl-6-chloroinosine

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: N-[(1S,trans)-2-hydroxycyclopentyl]adenosine 2',3',5'-tri-O-acetate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In isopropyl alcohol at 82℃; for 4h; Substitution;

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 6-chloro-[8-14C]purineriboside 2',3',5'-tri-O-acetate

: N-[(1S,trans)-2-hydroxycyclopentyl]-[8-14C]adenosine 2',3',5'-tri-O-acetate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In isopropyl alcohol at 82℃; for 4h; Substitution;

: 67-66-3
chloroform

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

phosphorus (V)-chloride: phosphorus (V)-chloride

(-)-cis-2-chloro-cyclopentylamine: (-)-cis-2-chloro-cyclopentylamine

...Expand

: 85-44-9
phthalic anhydride

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 2-(2S-Hydroxy-(S)-cyclopentyl)-isoindole-1,3-dione

Conditions

Conditions	Yield
In methanol; sodium methylate; ethyl acetate; toluene

: 676559-69-6
(2S,5R)-1-(2-chloroacetyl)-5-ethynylpyrrolidine-2-carbonitrile

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: (2S,5R)-5-ethynyl-1-{N-((2S)-2-hydroxycyclopentyl)glycyl}pyrrolidine-2-carbonitrile

Conditions

Conditions	Yield
With triethylamine In acetonitrile
With triethylamine In acetonitrile

: 1073973-05-3
(2,6-difluoro-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzonitrile)

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 1073974-02-3
2-fluoro-6-((1S,2S)-2-hydroxy-cyclopentylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-benzonitrile

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 60℃; for 4h;

: 68327-04-8
(1S,2S)-2-aminocyclopentanol hydrochloride

: 313279-15-1
4-((triisopropylsilyloxy)methyl)benzaldehyde

: C22H37NO2Si

Conditions

Conditions	Yield
With magnesium sulfate; triethylamine In dichloromethane at 20℃; for 3h;

(1S,2S)-trans-2-Aminocyclopentanol hydrochloride Specification

The CAS register number of Cyclopentanol,2-amino-, hydrochloride (1:1), (1S,2S)- is 68327-04-8. It also can be called as trans-(1S,2S)-2-Aminocyclopentanol Hydrochloride and the systematic name about this chemical is (1S,2S)-2-aminocyclopentanol hydrochloride. The molecular formula about this chemical is C₅H₁₁NO^.HCl and the molecular weight is 137.61. It belongs to the following product categories which include Amino Alcohols; Chiral Building Blocks; Organic Building Blocks and so on. This chemical is harmful if swallowed.

Physical properties about Cyclopentanol,2-amino-, hydrochloride (1:1), (1S,2S)- are: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 1; (4)ACD/KOC (pH 7.4): 1; (5)#H bond acceptors: 2; (6)#H bond donors: 3; (7)#Freely Rotating Bonds: 2; (8)Polar Surface Area: 12.47Å²; (9)Flash Point: 87.4 °C; (10)Enthalpy of Vaporization: 53.18 kJ/mol; (11)Boiling Point: 220.9 °C at 760 mmHg; (12)Vapour Pressure: 0.0229 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.O[C@H]1CCC[C@@H]1N
(2)InChI: InChI=1/C5H11NO.ClH/c6-4-2-1-3-5(4)7;/h4-5,7H,1-3,6H2;1H/t4-,5-;/m0./s1
(3)InChIKey: ZFSXKSSWYSZPGQ-FHAQVOQBBN
(4)Std. InChI: InChI=1S/C5H11NO.ClH/c6-4-2-1-3-5(4)7;/h4-5,7H,1-3,6H2;1H/t4-,5-;/m0./s1
(5)Std. InChIKey: ZFSXKSSWYSZPGQ-FHAQVOQBSA-N

Product Name

(1S,2S)-trans-2-Aminocyclopentanol hydrochloride

Synthetic route

(1S,2S)-trans-2-Aminocyclopentanol hydrochloride Specification

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