Product Name

  • Name

    (3S)-(-)-3-Acetamidopyrrolidine

  • EINECS -0
  • CAS No. 114636-31-6
  • Article Data5
  • CAS DataBase
  • Density 1.04 g/cm3
  • Solubility
  • Melting Point 56-58 °C
  • Formula C6H12N2O
  • Boiling Point 306.8 °C at 760 mmHg
  • Molecular Weight 128.174
  • Flash Point 150.8 °C
  • Transport Information
  • Appearance Colorless transparent liquid
  • Safety 26-36/37/39-45
  • Risk Codes 34-36/37/38
  • Molecular Structure Molecular Structure of 114636-31-6 ((3S)-(-)-3-Acetamidopyrrolidine)
  • Hazard Symbols IrritantXi
  • Synonyms Acetamide,N-3-pyrrolidinyl-, (S)-;(3S)-3-Acetamidopyrrolidine;(S)-3-Acetamidopyrrolidine;(S)-N-(Pyrrolidin-3-yl)ethanamide;N-(3S)-3-Pyrrolidinylacetamide;
  • PSA 41.13000
  • LogP 0.20410

Synthetic route

acetic anhydride
108-24-7

acetic anhydride

(3S)-3-azido-1-(phenylmethyl)pyrrolidine
114636-29-2

(3S)-3-azido-1-(phenylmethyl)pyrrolidine

A

N-[(3R)-3-pyrrolidinyl]acetamide
131900-62-4

N-[(3R)-3-pyrrolidinyl]acetamide

B

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

Conditions
ConditionsYield
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
...Expand
1,2-bis(4-bromo-2,6-dimethoxyphenyl)diazene

1,2-bis(4-bromo-2,6-dimethoxyphenyl)diazene

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N,N’-((3S,3'S)-((-diazene-1,2-diyl)bis(3,5-dimethoxy-4,1-phenylene))bis(pyrrolidine-1,3-diyl))diacetamide

N,N’-((3S,3'S)-((-diazene-1,2-diyl)bis(3,5-dimethoxy-4,1-phenylene))bis(pyrrolidine-1,3-diyl))diacetamide

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; ruphos In toluene at 100℃; for 18h; Inert atmosphere;94%
C45H29N5O

C45H29N5O

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

C51H41N7O2

C51H41N7O2

Conditions
ConditionsYield
at 20℃;92%
C45H29N5O

C45H29N5O

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

C51H41N7O2

C51H41N7O2

Conditions
ConditionsYield
With triethylamine at 20℃;92%
2-amino-4-formyl-5-trifluoromethyl-benzoic acid ethyl ester

2-amino-4-formyl-5-trifluoromethyl-benzoic acid ethyl ester

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

ethyl 4-[[(3S)-3-acetamidopyrrolidin-1-yl]methyl]-2-amino-5-(trifluoromethyl)benzoate

ethyl 4-[[(3S)-3-acetamidopyrrolidin-1-yl]methyl]-2-amino-5-(trifluoromethyl)benzoate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; for 1h;92%
7-chloro-2-(4-chlorobenzyl)-5-methylpyrazolo[1,5-a]pyrimidine

7-chloro-2-(4-chlorobenzyl)-5-methylpyrazolo[1,5-a]pyrimidine

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N-{(3S)-1-[2-(4-chlorobenzyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-yl}acetamide

N-{(3S)-1-[2-(4-chlorobenzyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-yl}acetamide

Conditions
ConditionsYield
With potassium carbonate In 1,4-dioxane at 95℃;86.4%
(4-benzenesulfonyl-6-chloropyridin-2-yl)-(5-methyl-1H-pyrazol-3-yl)amine

(4-benzenesulfonyl-6-chloropyridin-2-yl)-(5-methyl-1H-pyrazol-3-yl)amine

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N-{(S)-1-[4-benzenesulfonyl-6-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2-yl]pyrrolidin-3-yl}acetamide

N-{(S)-1-[4-benzenesulfonyl-6-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2-yl]pyrrolidin-3-yl}acetamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 120℃; for 4h;86%
3,7-dihydro-9,10-difluoro-3-methyl-7-oxo-2H-pyrido<3,2,1-ij><1,3,4>benzoxadiazine-6-carboxylic acid ethyl ester
137435-09-7

3,7-dihydro-9,10-difluoro-3-methyl-7-oxo-2H-pyrido<3,2,1-ij><1,3,4>benzoxadiazine-6-carboxylic acid ethyl ester

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

9-((S)-3-Acetylamino-pyrrolidin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3,3a-diaza-phenalene-5-carboxylic acid ethyl ester

9-((S)-3-Acetylamino-pyrrolidin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3,3a-diaza-phenalene-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With pyridine Heating;85%
C14H7Cl3N4O2S
896459-67-9

C14H7Cl3N4O2S

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

(S)-N-(1-(6-cyano-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-ylsulfonyl)pyrrolidin-3-yl)acetamide
896459-68-0

(S)-N-(1-(6-cyano-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-ylsulfonyl)pyrrolidin-3-yl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane for 14h;81%
C13H9BrClN3

C13H9BrClN3

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

C19H20BrN5O

C19H20BrN5O

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 100℃; for 3h; Sealed tube;81%
(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

2-tert-butyl-6-chloro-9H-purine

2-tert-butyl-6-chloro-9H-purine

N-[(S)-1-(2-tert-butyl-9H-purin-6-yl)pyrrolidin-3-yl]acetamide

N-[(S)-1-(2-tert-butyl-9H-purin-6-yl)pyrrolidin-3-yl]acetamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In ethanol at 100℃; for 16h;76%
2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]benzoyl chloride

2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]benzoyl chloride

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N-[(3S)-1-{2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]benzoyl}pyrrolidin-3-yl]acetamide

N-[(3S)-1-{2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]benzoyl}pyrrolidin-3-yl]acetamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h;76%
2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
885618-31-5

2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

(S)-N-(1-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-methyl)pyrrolidin-3-yl)acetamide

(S)-N-(1-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-methyl)pyrrolidin-3-yl)acetamide

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In chloroform at 20℃; for 16h;74%
p-benzyloxyphenylbromide
6793-92-6

p-benzyloxyphenylbromide

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N-[(S)-1-(4-benzyloxyphenyl)pyrrolidin-3-yl]acetamide

N-[(S)-1-(4-benzyloxyphenyl)pyrrolidin-3-yl]acetamide

Conditions
ConditionsYield
With potassium phosphate; CVT-2537 In dimethyl sulfoxide at 110℃; for 16h; Inert atmosphere;71%
N-((3-(3,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)propane-2-sulfonamide

N-((3-(3,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)propane-2-sulfonamide

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N-((3S)-1-(2-fluoro-4-((5S)-5-((1-methylethylsulfonamido)methyl)-4,5-dihydroisoxazol-3-yl)phenyl)pyrrolidin-3-yl)acetamide

N-((3S)-1-(2-fluoro-4-((5S)-5-((1-methylethylsulfonamido)methyl)-4,5-dihydroisoxazol-3-yl)phenyl)pyrrolidin-3-yl)acetamide

Conditions
ConditionsYield
With potassium carbonate at 135 - 140℃; Sealed tube; Inert atmosphere;68%
5-chloro-7-{[methoxy(methyl)amino]carbonyl}quinolin-8-yl trifluoromethanesulfonate
1312684-94-8

5-chloro-7-{[methoxy(methyl)amino]carbonyl}quinolin-8-yl trifluoromethanesulfonate

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

8-[(3S)-3-(acetylamino)pyrrolidin-1-yl]-5-chloro-N-methoxy-N-methylquinoline-7-carboxamide
1312685-07-6

8-[(3S)-3-(acetylamino)pyrrolidin-1-yl]-5-chloro-N-methoxy-N-methylquinoline-7-carboxamide

Conditions
ConditionsYield
With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate In tetrahydrofuran at 65℃;66%
(3R,4S)-4-(4-bromophenyl)-1-(2-fluoro-6-methylbenzyl)-N,N-dimethylpyrrolidin-3-amine

(3R,4S)-4-(4-bromophenyl)-1-(2-fluoro-6-methylbenzyl)-N,N-dimethylpyrrolidin-3-amine

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

C26H35FN4O

C26H35FN4O

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; XPhos In 1,4-dioxane at 100℃; under 1034.32 Torr; for 8h; Buchwald-Hartwig Coupling; Inert atmosphere; Sealed tube;64%
4,5-dichloro-3-nitropyridin-2-ylamine
662116-67-8

4,5-dichloro-3-nitropyridin-2-ylamine

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

(S)-N-(1-(2-amino-5-chloro-3-nitropyridin-4-yl)pyrrolidin-3-yl)acetamide

(S)-N-(1-(2-amino-5-chloro-3-nitropyridin-4-yl)pyrrolidin-3-yl)acetamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 45℃; for 18h;61%
2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(4-methoxybenzyl)oxy]benzoic acid

2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(4-methoxybenzyl)oxy]benzoic acid

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N-[(3S)-1-(2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(4-methoxybenzyl)oxy]benzoyl)pyrrolidin-3-yl]acetamide

N-[(3S)-1-(2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(4-methoxybenzyl)oxy]benzoyl)pyrrolidin-3-yl]acetamide

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 20h;59%
7-chloro-5-methyl-2-{1-[4-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine

7-chloro-5-methyl-2-{1-[4-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N-[(3S)-1-(5-methyl-2-{1-[4-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-yl]acetamide

N-[(3S)-1-(5-methyl-2-{1-[4-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-yl]acetamide

Conditions
ConditionsYield
With triethylamine In acetonitrile at 60℃; Inert atmosphere;46.1%
N-[1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-2-yl)ethyl]-6-fluoro-2-methylpyrido[3,4-d]pyrimidin-4-amine

N-[1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-2-yl)ethyl]-6-fluoro-2-methylpyrido[3,4-d]pyrimidin-4-amine

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N-[(3S)-1-(4-{[(1S)-1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-2-yl)ethyl]amino}-2-methylpyrido[3,4-d]pyrimidin-6-yl)pyrrolidin-3-yl]acetamide

N-[(3S)-1-(4-{[(1S)-1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-2-yl)ethyl]amino}-2-methylpyrido[3,4-d]pyrimidin-6-yl)pyrrolidin-3-yl]acetamide

Conditions
ConditionsYield
With triethylamine In 1-methyl-pyrrolidin-2-one at 170℃;46%
7-chloro-2-[1-(4-chlorophenyl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidine

7-chloro-2-[1-(4-chlorophenyl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidine

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N-[(3S)-1-{2-[1-(4-chlorophenyl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidin-7-yl}pyrrolidin-3-yl]acetamide

N-[(3S)-1-{2-[1-(4-chlorophenyl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidin-7-yl}pyrrolidin-3-yl]acetamide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 65℃;43.2%
6-(chloromethyl)-N-(4-(piperidin-1-yl)-2-(4-(3-(trifluoromethyl)benzylcarbamoyl)pyridin-2-yl)phenyl)picolinamide

6-(chloromethyl)-N-(4-(piperidin-1-yl)-2-(4-(3-(trifluoromethyl)benzylcarbamoyl)pyridin-2-yl)phenyl)picolinamide

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

(S)-6-((3-acetamidopyrrolidin-1-yl)methyl)-N-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)picolinamide

(S)-6-((3-acetamidopyrrolidin-1-yl)methyl)-N-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)picolinamide

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 60℃; for 3h;39%
(S)-2-(2-(2-(1H-pyrazol-1-yl)ethyl)-6-(methoxycarbonyl)-7-methyl-6,7,8,9-tetrahydro-3H-imidazo[4,5-f]quinolin-3-yl)acetic acid

(S)-2-(2-(2-(1H-pyrazol-1-yl)ethyl)-6-(methoxycarbonyl)-7-methyl-6,7,8,9-tetrahydro-3H-imidazo[4,5-f]quinolin-3-yl)acetic acid

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

methyl (S)-2-(2-(1H-pyrazol-1-yl)ethyl)-3-(2-((S)-3-acetamidopyrrolidin-1-yl)-2-oxoethyl)-7-methyl-3,7,8,9-tetrahydro-6H-imidazo[4,5-f]quinoline-6-carboxylate

methyl (S)-2-(2-(1H-pyrazol-1-yl)ethyl)-3-(2-((S)-3-acetamidopyrrolidin-1-yl)-2-oxoethyl)-7-methyl-3,7,8,9-tetrahydro-6H-imidazo[4,5-f]quinoline-6-carboxylate

Conditions
ConditionsYield
With 2-chloro-1,3-dimethylimidazolinium chloride; N-ethyl-N,N-diisopropylamine In 1,4-dioxane; 1,2-dichloro-ethane at 20℃; for 20h;34%
methyl 6-(4-bromo-3-methylphenyl)pyrazine-2-carboxylate

methyl 6-(4-bromo-3-methylphenyl)pyrazine-2-carboxylate

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

methyl 6-[4-[(3S)-3-acetamidopyrrolidin-1-yl]-3-methylphenyl]pyrazine-2-carboxylate

methyl 6-[4-[(3S)-3-acetamidopyrrolidin-1-yl]-3-methylphenyl]pyrazine-2-carboxylate

Conditions
ConditionsYield
With potassium phosphate; palladium diacetate; ruphos In toluene for 3h; Molecular sieve; Inert atmosphere; Reflux;33%
(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

1-cyclopropyl-7-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid - difluoroboron complex

1-cyclopropyl-7-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid - difluoroboron complex

7-((S)-3-Acetylamino-pyrrolidin-1-yl)-1-cyclopropyl-8-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-((S)-3-Acetylamino-pyrrolidin-1-yl)-1-cyclopropyl-8-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
With triethylamine In dimethyl sulfoxide at 120℃; for 14h;31%
2-((3R,4aR,6aS,7R,10bR)-3-cyclopentyl-6a,10b-dimethyl-8-methylidenedecahydro-1H-naphtho[2,1-d][1,3]dioxin-7-yl)acetaldehyde

2-((3R,4aR,6aS,7R,10bR)-3-cyclopentyl-6a,10b-dimethyl-8-methylidenedecahydro-1H-naphtho[2,1-d][1,3]dioxin-7-yl)acetaldehyde

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N-((3 S)-1-(2-((3R,4aR,6aS,7R,10bR)-3-cyclopentyl-6a,10b-dimethyl-8-methylenedecahydro-1H-naphtho[2,1-d][1,3]dioxain-7-yl)ethyl)pyrrolidin-3-yl)acetamide

N-((3 S)-1-(2-((3R,4aR,6aS,7R,10bR)-3-cyclopentyl-6a,10b-dimethyl-8-methylenedecahydro-1H-naphtho[2,1-d][1,3]dioxain-7-yl)ethyl)pyrrolidin-3-yl)acetamide

Conditions
ConditionsYield
Stage #1: 2-((3R,4aR,6aS,7R,10bR)-3-cyclopentyl-6a,10b-dimethyl-8-methylidenedecahydro-1H-naphtho[2,1-d][1,3]dioxin-7-yl)acetaldehyde; (S)-N-(pyrrolidin-3-yl)acetamide In tetrahydrofuran at 20℃; for 10h;
Stage #2: With sodium cyanoborohydride In tetrahydrofuran at 20℃; for 2h;		29.1%
2-(2-(3-(bromomethyl)benzamido)-5-(piperidin-1-yl)phenyl)-N-(3-(trifluoromethyl)benzyl)isonicotinamide

2-(2-(3-(bromomethyl)benzamido)-5-(piperidin-1-yl)phenyl)-N-(3-(trifluoromethyl)benzyl)isonicotinamide

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

(S)-2-(2-(3-((3-Acetamidopyrrolidin-1-yl)methyl)benzamido)-5-(piperidin-1-yl)phenyl)-N-(3-(trifluoromethyl)benzyl)isonicotinamide

(S)-2-(2-(3-((3-Acetamidopyrrolidin-1-yl)methyl)benzamido)-5-(piperidin-1-yl)phenyl)-N-(3-(trifluoromethyl)benzyl)isonicotinamide

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 70℃; for 3h;24%
7-chloro-2-[1-(5-chloropyridin-2-yl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidine

7-chloro-2-[1-(5-chloropyridin-2-yl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidine

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

N-[(3S)-1-{2-[1-(5-chloropyridin-2-yl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidin-7-yl}pyrrolidin-3-yl]acetamide

N-[(3S)-1-{2-[1-(5-chloropyridin-2-yl)ethyl]-5-methylpyrazolo[1,5-a]pyrimidin-7-yl}pyrrolidin-3-yl]acetamide

Conditions
ConditionsYield
With potassium carbonate In 1,4-dioxane at 90℃; for 10h;15.2%
2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

(S)-N-(pyrrolidin-3-yl)acetamide
114636-31-6

(S)-N-(pyrrolidin-3-yl)acetamide

(S)-N-(1-(2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)pyrrolidin-3-yl)acetamide

(S)-N-(1-(2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)pyrrolidin-3-yl)acetamide

Conditions
ConditionsYield
With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1.5h;15%

(3S)-(-)-3-Acetamidopyrrolidine Specification

The (3S)-(-)-3-Acetamidopyrrolidine, also known as (S)-N-Pyrrolidin-3-ylacetamide, is an organic compound with the formula C6H12N2O. It belongs to the product categories of 3-Aminopyrrolidines; Amides (Chiral); Chiral 3-Aminopyrrolidines; Chiral Building Blocks; Synthetic Organic Chemistry. With the CAS registry number 114636-31-6, its IUPAC name is N-[(3S)-pyrrolidin-3-yl]acetamide. It is stable at common pressure and temperature, and it should be sealed and stored in a cool and dry place.

Physical properties of (3S)-(-)-3-Acetamidopyrrolidine: (1)ACD/LogP: -1.24; (2)ACD/LogD (pH 5.5): -4.3; (3)ACD/LogD (pH 7.4): -3.47; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 1; (11)Index of Refraction: 1.485; (12)Molar Refractivity: 35.17 cm3; (13)Molar Volume: 122.5 cm3; (14)Surface Tension: 36 dyne/cm; (15)Density: 1.04 g/cm3; (16)Flash Point: 150.8 °C; (17)Enthalpy of Vaporization: 54.74 kJ/mol; (18)Boiling Point: 306.8 °C at 760 mmHg; (19)Vapour Pressure: 0.000752 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(=O)NC1CCNC1
(2)Isomeric SMILES: CC(=O)N[C@H]1CCNC1
(3)InChI: InChI=1S/C6H12N2O/c1-5(9)8-6-2-3-7-4-6/h6-7H,2-4H2,1H3,(H,8,9)/t6-/m0/s1
(4)InChIKey: HDCCJUCOIKLZNM-LURJTMIESA-N

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