N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In tetrahydrofuran at 15 - 20℃; for 0.5h; | 95% |
N-(9-fluorenylmethoxycarbonyl)-N-n-decylaminoethanol
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
With sodium hypochlorite solution; 2,2,6,6-tetramethylpiperidin-1-ol; sodium hydrogencarbonate; potassium bromide In dichloromethane; water at -5℃; pH=8.5; | 92.4% |
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-n-decylaminoethanol With N-ethyl-N,N-diisopropylamine In dichloromethane at -5℃; for 0.25h; Stage #2: With sulfur trioxide pyridine complex; dimethyl sulfoxide In dichloromethane at -5℃; for 0.5h; | 90% |
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-n-decylaminoethanol With N-ethyl-N,N-diisopropylamine In dichloromethane at -5℃; for 0.0833333h; Stage #2: With pyridine; sulfur trioxide In dichloromethane; dimethyl sulfoxide at -5℃; for 0.5h; |
C29H41NO4
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
With hydrogenchloride In dichloromethane at -10 - 30℃; | 82.2% |
With formic acid at 20℃; for 4h; | |
Multi-step reaction with 2 steps 1.1: formic acid / toluene / 4 h / 20 °C 1.2: 1 h 2.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.5 h / 15 - 20 °C View Scheme |
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
Stage #1: N-FMOC-N-allyldecylamine With ozone In methanol; dichloromethane; oxygen at -65 - -55℃; for 2.5h; Stage #2: With triethylamine In methanol; dichloromethane at -55 - 21℃; for 3h; Stage #3: With hydrogenchloride; water In methanol; dichloromethane | 61% |
oxalyl dichloride
N-(9-fluorenylmethoxycarbonyl)-N-n-decylaminoethanol
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
With sulfuric acid; triethylamine In n-heptane; dichloromethane; water; dimethyl sulfoxide | |
With sulfuric acid; triethylamine In n-heptane; dichloromethane; water; dimethyl sulfoxide |
caprinaldehyde
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: butan-1-ol / 60 °C 2.1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 48 h / 50 °C / 2280.15 Torr 3.1: sodium hydroxide / toluene; water / 0.08 - 0.17 h / 0 - 5 °C 3.2: 0.92 h / 0 - 5 °C 4.1: formic acid / 4 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: butan-1-ol / 60 °C 2.1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 48 h / 50 °C / 2280.15 Torr 3.1: sodium hydroxide / toluene; water / 0.08 - 0.17 h / 0 - 5 °C 3.2: 0.92 h / 0 - 5 °C 4.1: formic acid / toluene / 4 h / 20 °C 4.2: 1 h 5.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.5 h / 15 - 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: butan-1-ol / 60 °C 2: hydrogen / platinum on activated charcoal / butan-1-ol; water / 48 h / 50 °C / 2280.15 Torr 3: toluene / 40 - 50 °C 4: sodium hydroxide / toluene; water / 1.17 h / 0 - 5 °C 5: formic acid / 4 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: butan-1-ol / 60 °C 2.1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 48 h / 50 °C / 2280.15 Torr 3.1: toluene / 40 - 50 °C 4.1: sodium hydroxide / toluene; water / 1.17 h / 0 - 5 °C 5.1: formic acid / toluene / 4 h / 20 °C 5.2: 1 h 6.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.5 h / 15 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 5%-palladium/activated carbon; hydrogen / methanol / 20 - 100 °C / 3750.38 Torr 2: N-ethyl-N,N-diisopropylamine / dichloromethane / -20 - 30 °C 3: hydrogenchloride / dichloromethane / -10 - 30 °C View Scheme |
1-aminodecane
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: butan-1-ol; water / 60 °C 2.1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 16 h / 50 °C 3.1: sodium hydroxide / toluene; water / 0.08 - 0.17 h / 0 - 5 °C 3.2: 0.92 h / 0 - 5 °C 4.1: formic acid / 4 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 3.5 h / 50 °C / 3750.38 Torr 2.1: sodium hydroxide / toluene; water / 0.08 - 0.17 h / 0 - 5 °C 2.2: 0.92 h / 0 - 5 °C 3.1: formic acid / 4 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 3.5 h / 50 °C / 3750.38 Torr 2.1: sodium hydroxide / toluene; water / 0.08 - 0.17 h / 0 - 5 °C 2.2: 0.92 h / 0 - 5 °C 3.1: formic acid / toluene / 4 h / 20 °C 3.2: 1 h 4.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.5 h / 15 - 20 °C View Scheme |
C7H8O3S*C14H31NO2
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / toluene; water / 1.17 h / 0 - 5 °C 2: formic acid / 4 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydroxide / toluene; water / 1.17 h / 0 - 5 °C 2.1: formic acid / toluene / 4 h / 20 °C 2.2: 1 h 3.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.5 h / 15 - 20 °C View Scheme |
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 48 h / 50 °C / 2280.15 Torr 2.1: sodium hydroxide / toluene; water / 0.08 - 0.17 h / 0 - 5 °C 2.2: 0.92 h / 0 - 5 °C 3.1: formic acid / 4 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 48 h / 50 °C / 2280.15 Torr 2.1: sodium hydroxide / toluene; water / 0.08 - 0.17 h / 0 - 5 °C 2.2: 0.92 h / 0 - 5 °C 3.1: formic acid / toluene / 4 h / 20 °C 3.2: 1 h 4.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.5 h / 15 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 48 h / 50 °C / 2280.15 Torr 2: toluene / 40 - 50 °C 3: sodium hydroxide / toluene; water / 1.17 h / 0 - 5 °C 4: formic acid / 4 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 48 h / 50 °C / 2280.15 Torr 2.1: toluene / 40 - 50 °C 3.1: sodium hydroxide / toluene; water / 1.17 h / 0 - 5 °C 4.1: formic acid / toluene / 4 h / 20 °C 4.2: 1 h 5.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.5 h / 15 - 20 °C View Scheme |
decylaminoethanal dimethylacetal
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide / toluene; water / 0.08 - 0.17 h / 0 - 5 °C 1.2: 0.92 h / 0 - 5 °C 2.1: formic acid / 4 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydroxide / toluene; water / 0.08 - 0.17 h / 0 - 5 °C 1.2: 0.92 h / 0 - 5 °C 2.1: formic acid / toluene / 4 h / 20 °C 2.2: 1 h 3.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.5 h / 15 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: toluene / 40 - 50 °C 2: sodium hydroxide / toluene; water / 1.17 h / 0 - 5 °C 3: formic acid / 4 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: toluene / 40 - 50 °C 2.1: sodium hydroxide / toluene; water / 1.17 h / 0 - 5 °C 3.1: formic acid / toluene / 4 h / 20 °C 3.2: 1 h 4.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.5 h / 15 - 20 °C View Scheme |
decylimminoethanolacetal
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 16 h / 50 °C 2.1: sodium hydroxide / toluene; water / 0.08 - 0.17 h / 0 - 5 °C 2.2: 0.92 h / 0 - 5 °C 3.1: formic acid / 4 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 16 h / 50 °C 2.1: sodium hydroxide / toluene; water / 0.08 - 0.17 h / 0 - 5 °C 2.2: 0.92 h / 0 - 5 °C 3.1: formic acid / toluene / 4 h / 20 °C 3.2: 1 h 4.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.5 h / 15 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 16 h / 50 °C 2: toluene / 40 - 50 °C 3: sodium hydroxide / toluene; water / 1.17 h / 0 - 5 °C 4: formic acid / 4 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: hydrogen / platinum on activated charcoal / butan-1-ol; water / 16 h / 50 °C 2.1: toluene / 40 - 50 °C 3.1: sodium hydroxide / toluene; water / 1.17 h / 0 - 5 °C 4.1: formic acid / toluene / 4 h / 20 °C 4.2: 1 h 5.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.5 h / 15 - 20 °C View Scheme |
1-Decanol
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate / dichloromethane / -10 - 50 °C 2: 5%-palladium/activated carbon; hydrogen / methanol / 20 - 100 °C / 3750.38 Torr 3: N-ethyl-N,N-diisopropylamine / dichloromethane / -20 - 30 °C 4: hydrogenchloride / dichloromethane / -10 - 30 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: pyridine / dichloromethane / 24 h / 20 °C 2.1: ethanol / 5 h / 90 °C 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / -5 °C 4.2: 0.5 h / -5 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: dichloromethane / 0.08 h / 0 °C 1.2: 24 h / 20 - 25 °C 2.1: ethanol / 24 h / 90 °C 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / -5 °C 4.2: 0.5 h / -5 °C View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 12 h / 0 - 20 °C 2: ethanol / 12 h / 90 °C 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C 4: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-tetramethylpiperidin-1-ol; sodium hypochlorite solution / dichloromethane; water / -5 °C / pH 8.5 View Scheme |
methanesulfonic acid decyl ester
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ethanol / 5 h / 90 °C 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / -5 °C 3.2: 0.5 h / -5 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: ethanol / 24 h / 90 °C 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / -5 °C 3.2: 0.5 h / -5 °C View Scheme | |
Multi-step reaction with 3 steps 1: ethanol / 12 h / 90 °C 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C 3: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-tetramethylpiperidin-1-ol; sodium hypochlorite solution / dichloromethane; water / -5 °C / pH 8.5 View Scheme |
(fluorenylmethoxy)carbonyl chloride
2-(n-Decylamino)ethanol
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / -5 °C 2.2: 0.5 h / -5 °C View Scheme |
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
Stage #1: N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester; vancomycin hydrochloride With N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 15h; Stage #2: With methanol; trifluoroacetic acid In DMF (N,N-dimethyl-formamide) at 0℃; for 1h; Stage #3: With hydrogenchloride; borane pyridine; water; methylamine more than 3 stages; |
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
Conditions | Yield |
---|---|
In methanol; N,N-dimethyl-formamide at 65℃; for 2h; |
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
vancomycin hydrochloride
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 55℃; for 4h; | |
Stage #1: vancomycin hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 55 - 60℃; Stage #2: N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester In N,N-dimethyl-formamide at 25℃; for 18h; Stage #3: With trifluoroacetic acid In methanol; N,N-dimethyl-formamide at 25℃; for 2h; Temperature; Reagent/catalyst; |
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
vancomycin hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester; vancomycin hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25 - 65℃; for 18h; Stage #2: With sodium cyanoborohydride; trifluoroacetic acid In methanol; N,N-dimethyl-formamide at 20℃; for 3h; Stage #3: With piperidine for 1h; Temperature; Reagent/catalyst; |
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
L-Lactic acid
vancomycin hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester; vancomycin hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 55 - 60℃; Stage #2: With trifluoroacetic acid In methanol; N,N-dimethyl-formamide at 2℃; Stage #3: L-Lactic acid Further stages; |
N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
vancomycin
Conditions | Yield |
---|---|
Stage #1: N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester; vancomycin With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20 - 25℃; for 2h; Stage #2: With sodium cyanoborohydride; trifluoroacetic acid In methanol; N,N-dimethyl-formamide at 20 - 25℃; for 1h; | 700 mg |
The Carbamic acid,decyl(2-oxoethyl)-, 9H-fluoren-9-ylmethyl ester (9CI) is an organic compound with the formula C27H35NO3. The systematic name of this chemical is 9H-fluoren-9-ylmethyl decyl(2-oxoethyl)carbamate. With the CAS registry number 239088-22-3, it is also named as carbamic acid, N-decyl-N-(2-oxoethyl)-, 9H-fluoren-9-ylmethyl ester.
Physical properties about Carbamic acid,decyl(2-oxoethyl)-, 9H-fluoren-9-ylmethyl ester (9CI) are: (1)ACD/LogP: 8.18; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 9; (4)ACD/LogD (pH 7.4): 9; (5)ACD/BCF (pH 5.5): 1000000; (6)ACD/BCF (pH 7.4): 1000000; (7)ACD/KOC (pH 5.5): 1130350; (8)ACD/KOC (pH 7.4): 1130350; (9)#H bond acceptors: 4; (10)#Freely Rotating Bonds: 14; (11)Polar Surface Area: 46.61 Å2; (12)Index of Refraction: 1.547; (13)Molar Refractivity: 124.4 cm3; (14)Molar Volume: 392.039 cm3; (15)Polarizability: 49.316×10-24cm3; (16)Surface Tension: 43.634 dyne/cm; (17)Density: 1.075 g/cm3; (18)Flash Point: 286.787 °C; (19)Enthalpy of Vaporization: 83.07 kJ/mol; (20)Boiling Point: 550.59 °C at 760 mmHg.
You can still convert the following datas into molecular structure:
(1)SMILES: O=CCN(C(=O)OCC3c1ccccc1c2c3cccc2)CCCCCCCCCC
(2)InChI: InChI=1/C27H35NO3/c1-2-3-4-5-6-7-8-13-18-28(19-20-29)27(30)31-21-26-24-16-11-9-14-22(24)23-15-10-12-17-25(23)26/h9-12,14-17,20,26H,2-8,13,18-19,21H2,1H3
(3)InChIKey: AWGULBUAOMFSCY-UHFFFAOYAY
(4)Std. InChI: InChI=1S/C27H35NO3/c1-2-3-4-5-6-7-8-13-18-28(19-20-29)27(30)31-21-26-24-16-11-9-14-22(24)23-15-10-12-17-25(23)26/h9-12,14-17,20,26H,2-8,13,18-19,21H2,1H3
(5)Std. InChIKey: AWGULBUAOMFSCY-UHFFFAOYSA-N
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