(S)-(-)-2-Chloropropionic acid supplier

Name
(S)-(-)-2-Chloropropionic acid
EINECS 411-150-5
CAS No. 29617-66-1
Article Data49
CAS DataBase
Density 1.285 g/cm³
Solubility soluble in water
Melting Point 4 °C
Formula C₃H₅ClO₂
Boiling Point 189 °C at 760 mmHg
Molecular Weight 108.525
Flash Point 68.1 °C
Transport Information UN 2511 8/PG 3
Appearance colourless oil
Safety 23-26-28-36/37/39-45
Risk Codes 21/22-35
Molecular Structure
Hazard Symbols C
Synonyms (2S)-2-chloropropanoic acid;(S)-2-Chloropropionic acid;Propionic acid, 2-chloro-, L- (8CI);Propanoic acid, 2-chloro-, (S)-;alpha-L-Chloropropionic acid;S-2-Chloropropionic acid;(S)-2-Chloropropanoic acid;L-2-Chloropropanoic acid;(2S)-Chloropropanoic acid;L-2-chloropropinonical;
PSA 37.30000
LogP 0.69830

Synthetic route

: 56-41-7
L-alanin

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; nitrosylchloride In water at 0℃; for 1h; Temperature;	94%
With hydrogenchloride; sodium nitrite In water at -5 - 20℃;	89%
Stage #1: L-alanin With hydrogenchloride; tartaric acid; iron(II) chloride In water for 1h; Stage #2: With sodium nitrite In water at 0℃; for 4h; Reagent/catalyst;	85.4%

: (1R,2R)-2-(naphthalen-2-yloxy)cyclohexyl (S)-2-chloropropanoate

A: 29617-66-1
(S)-2-chloropropanoic acid

B: trans-2-(naphthalen-2-yloxy)cyclohexan-1-ol

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane; water at 50℃; for 24h; Inert atmosphere;	A 91% B 93%

: C20H19ClO2

A: 29617-66-1
(S)-2-chloropropanoic acid

B: 9,10-dihydro-9,10-ethanoanthracene-11-methanol

C: 7474-05-7
(R)-2-chloropropionic acid

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 50℃; for 8h; Inert atmosphere; Resolution of racemate;	A n/a B 91% C n/a

...Expand

: (S)-2-Chloro-propionic acid (R)-4,4-dimethyl-2-oxo-1-phenyl-pyrrolidin-3-yl ester

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran at 0℃; for 0.25h;	86%

: 74497-15-7
(+)-ethyl 2-chloropropionate

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water	85%

: 56-41-7
L-alanine

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite at 0℃; for 20h;	71%

: 83261-15-8
(S)-2-Chlorpropionsaeure-isobutylester

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With potassium hydroxide In water at 0℃;	59%

: 127304-29-4
(2R,3S)-(+)-3-chlorobutane-2-ol

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With potassium hydroxide; bromine at 50℃;

: 73246-45-4
methyl-(S)-2-chloropropionate

A: 67-56-1
methanol

B: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
subtilisin In water at 30℃; Kinetics;
With 2-(di(2-hydroxyethyl)amino)ethanesulfonic acid; esterase from Pseudomonas fluorescens In water at 25℃; pH=7.20; Enzyme kinetics;
With 2-(di(2-hydroxyethyl)amino)ethanesulfonic acid; lipase from Ophiostoma piliferum In water at 25℃; pH=7.20; Enzyme kinetics;
With 2-(di(2-hydroxyethyl)amino)ethanesulfonic acid; lipase from Bacillus thermocatenulanatus In water at 40℃; pH=7.20; Enzyme kinetics;

: 129974-79-4, 129974-81-8, 129974-82-9
(RS)-1-Pentylpropynyl (L)-2-chloropropanoate

A: 29617-66-1
(S)-2-chloropropanoic acid

B: 32556-71-1
1-octyn-3-ol

C: 129974-82-9
(R)-1-Pentylpropynyl (L)-2-chloropropanoate

Conditions

Conditions	Yield
With water; lipase CC lipase P;
With water; lipase CC Product distribution; or lipase P;
With lipase CC; water or lipase P;

...Expand

: 129974-80-7, 129974-83-0, 129974-84-1
(RS)-Bicyclo<2.2.1>hept-2-yl (L)-2-chloropropanoate

A: 29617-66-1
(S)-2-chloropropanoic acid

B: 497-36-9, 497-37-0, 1632-68-4, 24325-44-8, 29583-34-4, 36779-79-0, 60133-16-6, 61277-90-5, 61277-93-8
(S)-Bicyclo[2.2.1]heptan-2-ol

C: 129974-80-7, 129974-83-0, 129974-84-1
(1R)-Bicyclo<2.2.1>hept-2-yl (L)-2-chloropropanoate

Conditions

Conditions	Yield
With water; lipase CC lipase P;
With water; lipase CC Product distribution; lipase P;

...Expand

: 598-78-7
(R,S)-2-chloropropionic acid

: 29617-66-1
(S)-2-chloropropanoic acid

: 167937-27-1
1,2:5,6-di-O-isopropylidene-α-D-glucofuranos-3-O-yl α-chloropropionate

A: 29617-66-1
(S)-2-chloropropanoic acid

B: 7474-05-7
(R)-2-chloropropionic acid

Conditions

Conditions	Yield
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran for 0.5h; Yields of byproduct given. Title compound not separated from byproducts;

: 17639-93-9
2-chloro-propionic acid methyl ester

A: 29617-66-1
(S)-2-chloropropanoic acid

B: 7474-05-7
(R)-2-chloropropionic acid

Conditions

Conditions	Yield
With Aspergillus niger lipase; sodium acetate buffer In diethyl ether Title compound not separated from byproducts;

barium salt of/the/ L(-)-p-toluenesulfonyllactic acid: barium salt of/the/ L(-)-p-toluenesulfonyllactic acid

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With acetone; lithium chloride

D(+)-p-toluenesulfonyllactic acid: D(+)-p-toluenesulfonyllactic acid

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With water; acetone; lithium chloride
With hydrogenchloride

dextrorotatory α-chloro-propionyl chloride: dextrorotatory α-chloro-propionyl chloride

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With water at 25℃;

dextrorotatory 2-chloro-propanol-(1): dextrorotatory 2-chloro-propanol-(1)

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With chromic acid at 25℃;

DL-2-chloro-propionic acid: DL-2-chloro-propionic acid

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
ueber das Cinchoninsalz;

L(+)-alanine: L(+)-alanine

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; nitric acid; urea

L-erythro-3-chloro-butan-2-ol: L-erythro-3-chloro-butan-2-ol

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With nitric acid; sodium nitrite

: 7647-01-0
hydrogenchloride

: 130368-69-3
(2R)-2-(4-Toluenesulfonyloxy)propionic Acid

lithium chloride: lithium chloride

: 29617-66-1
(S)-2-chloropropanoic acid

...Expand

: 130368-69-3
(2R)-2-(4-Toluenesulfonyloxy)propionic Acid

: 7732-18-5
water

lithium chloride: lithium chloride

: 29617-66-1
(S)-2-chloropropanoic acid

...Expand

: 130368-69-3
(2R)-2-(4-Toluenesulfonyloxy)propionic Acid

: 67-64-1
acetone

lithium chloride: lithium chloride

: 29617-66-1
(S)-2-chloropropanoic acid

...Expand

: 692291-15-9
2-chloropropanal

A: 29617-66-1
(S)-2-chloropropanoic acid

B: 7474-05-7
(R)-2-chloropropionic acid

Conditions

Conditions	Yield
With potassium permanganate; disodium hydrogenphosphate; tert-butyl alcohol for 0.0166667h; Title compound not separated from byproducts;

: 598-79-8
2-Chloroacrylic acid

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With potassium phosphate buffer; Burkholderia sp. WS expressing reductase at 30℃; pH=7.1;

: 598-78-7
(R,S)-2-chloropropionic acid

: 71-36-3
butan-1-ol

A: 29617-66-1
(S)-2-chloropropanoic acid

B: 79398-16-6
(R)-2-Chloro-propionic acid butyl ester

Conditions

Conditions	Yield
With iron oxide-Candida rugosa (E.C.3.1.1.3) lipase In hexane at 30℃; for 168h;

...Expand

: 73246-45-4
methyl-(S)-2-chloropropionate

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 29617-66-1
(S)-2-chloropropanoic acid

: 115-11-7
isobutene

: 101617-24-7
(S)-tert-butyl 2-chloropropanoate

Conditions

Conditions	Yield
With hydrogen cation	100%
With hydrogen cation	93%
With sulfuric acid In dichloromethane at 20℃; for 48h;	73%

: 29617-66-1
(S)-2-chloropropanoic acid

: 70110-24-6
(S)-2-chloropropionyl chloride

Conditions

Conditions	Yield
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 25℃; for 3h;	99%
With thionyl chloride for 4h; Product distribution / selectivity; Reflux;	88.2%
With benzoyl chloride at 150℃;	52%

: 29617-66-1
(S)-2-chloropropanoic acid

: 108-95-2
phenol

: 1129-46-0
(R)-(+)-2-phenoxypropionic acid

Conditions

Conditions	Yield
Stage #1: phenol With sodium hydroxide In water at 55℃; for 0.5h; Stage #2: (S)-2-chloropropanoic acid In water at 60℃; for 2h; Temperature; Reagent/catalyst;	96.6%
With water; sodium hydroxide at 50 - 70℃; Inert atmosphere;	95%

: 106-41-2
4-bromo-phenol

: 29617-66-1
(S)-2-chloropropanoic acid

: 37819-43-5
(2S)-2-(4-bromophenoxy)propanoic acid

Conditions

Conditions	Yield
Stage #1: 4-bromo-phenol With sodium hydride In tetrahydrofuran for 1h; Heating / reflux; Stage #2: (S)-2-chloropropanoic acid In tetrahydrofuran for 120h; Heating / reflux; Stage #3: With hydrogenchloride In dichloromethane at 20℃;	96.4%

: 29617-66-1
(S)-2-chloropropanoic acid

: 582-52-5
1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

: 73892-71-4, 74112-33-7, 79982-05-1
3-O-(D-1-carboxyethyl)-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

Conditions

Conditions	Yield
With sodium hydride In 1,4-dioxane at 65℃; for 3h;	96%

: 29617-66-1
(S)-2-chloropropanoic acid

: 69323-66-6
benzyl 2-acetamido-2-deoxy-5,6-O-isopropylidene-α-D-mannofuranoside

: 69323-68-8, 79943-18-3, 81082-00-0
benzyl 2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-5,6-O-isopropylidene-α-D-mannofuranoside

Conditions

Conditions	Yield
With sodium hydride In 1,4-dioxane at 65℃; for 3h;	95%

: 78246-81-8
benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-α-D-glucopyranoside

: 29617-66-1
(S)-2-chloropropanoic acid

: 73089-68-6
benzyl 2-acetamido-4,6-O-benzylidene-3-O-[(R)-1-carboxyethyl]-2-deoxy-α-D-glucopyranoside

Conditions

Conditions	Yield
Stage #1: benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-α-D-glucopyranoside With sodium hydride In 1,4-dioxane; mineral oil at 60℃; for 0.0833333h; Inert atmosphere; Stage #2: (S)-2-chloropropanoic acid In 1,4-dioxane; mineral oil at 60℃; for 16.5h; Inert atmosphere;	94%
Stage #1: benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-α-D-glucopyranoside With sodium hydride In 1,4-dioxane at 95℃; for 2h; Stage #2: (S)-2-chloropropanoic acid In 1,4-dioxane at 60℃; for 3h;	80%
With sodium hydride In 1,4-dioxane at 65℃;	80%
Stage #1: benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-α-D-glucopyranoside With sodium hydride In 1,4-dioxane; mineral oil at 70 - 95℃; for 1h; Williamson Ether Synthesis; Stage #2: (S)-2-chloropropanoic acid In 1,4-dioxane; mineral oil at 65 - 70℃; for 25h; Williamson Ether Synthesis;	78%
With sodium hydride In 1,4-dioxane; mineral oil at 0 - 70℃; for 3h;	18 g

: 29617-66-1
(S)-2-chloropropanoic acid

: 491-30-5
1-isoquinolone

: 1255662-58-8
(R)-2-(1-oxoisoquinolin-2(1H)-yl)propanoic acid

Conditions

Conditions	Yield
Stage #1: (S)-2-chloropropanoic acid With magnesium tert butanolate In tetrahydrofuran at 35℃; for 0.166667h; Inert atmosphere; Stage #2: With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere; Stage #3: 1-isoquinolone In tetrahydrofuran at 20 - 55℃; for 14.5h; Inert atmosphere; optical yield given as %ee; stereospecific reaction;	94%

: 29617-66-1
(S)-2-chloropropanoic acid

: 610314-16-4
(S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(4-methoxy-benzylamino)-propionic acid methyl ester

: 1342305-95-6
N-[(S)-2-chloropropionyl]-N-p-methoxybenzyl-L-Tyr(2,6-dichlorobenzyl)-OMe

Conditions

Conditions	Yield
Stage #1: (S)-2-chloropropanoic acid With trichloroacetonitrile; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 1h; Stage #2: (S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(4-methoxy-benzylamino)-propionic acid methyl ester With methyloxirane In tetrahydrofuran	93%

: 29617-66-1
(S)-2-chloropropanoic acid

: 175519-63-8
2-acetamido-4,6-O-benzylidene-N-benzyloxycarbonyl-1,5-imino-1,2,5-trideoxy-D-glucitol

: 1356848-62-8
2-acetamido-4,6-O-benzylidene-1,5-(benzyloxycarbonyl)imino-3-O-[(1R)-1-carboxy]ethyl-1,2,5-trideoxy-D-glucitol

Conditions

Conditions	Yield
Stage #1: 2-acetamido-4,6-O-benzylidene-N-benzyloxycarbonyl-1,5-imino-1,2,5-trideoxy-D-glucitol With sodium hydride In tetrahydrofuran; oil at 60℃; for 0.5h; Inert atmosphere; Stage #2: (S)-2-chloropropanoic acid In tetrahydrofuran; oil at 20 - 60℃; for 21h;	91%

: 100-02-7
4-nitro-phenol

: 29617-66-1
(S)-2-chloropropanoic acid

: 2852-88-2
R-(+)-2- (4-nitrophenoxy) propionic acid

Conditions

Conditions	Yield
Stage #1: 4-nitro-phenol With sodium hydroxide In water at 75℃; for 0.5h; pH=13; Stage #2: (S)-2-chloropropanoic acid In water at 75℃; for 2h; Temperature; pH-value;	90.9%

: 29617-66-1
(S)-2-chloropropanoic acid

: Benzyl 2-deoxy-4,6-O-isopropylidene-2-(2-tetradecylhexadecanoylamino)-α-D-glucopyranoside

: 81639-20-5
Benzyl 3-O-(D-1-carboxyethyl)-2-deoxy-4,6-O-isopropylidene-2-(2-tetradecylhexadecanoylamino)-α-D-glucopyranoside

Conditions

Conditions	Yield
With sodium hydride In 1,4-dioxane 1.) 90 deg C, 1 h, 2.) 60 deg C, 5 h;	88%

: 29617-66-1
(S)-2-chloropropanoic acid

: 1342305-93-4
C25H27NO4

: 1342305-94-5
C28H30ClNO5

Conditions

Conditions	Yield
Stage #1: (S)-2-chloropropanoic acid With trichloroacetonitrile; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 1h; Stage #2: C25H27NO4 With methyloxirane In tetrahydrofuran	88%

: 29617-66-1
(S)-2-chloropropanoic acid

: (2S,4aR,7R,8R,8aS)-7-azido-6-(benzyloxy)-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-8-ol

: (R)-2-(((2S,4aR,7R,8R,8aS)-7-azido-6-(benzyloxy)-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-8-yI)oxy)propanoic acid

Conditions

Conditions	Yield
Stage #1: (2S,4aR,7R,8R,8aS)-7-azido-6-(benzyloxy)-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-8-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Inert atmosphere; Stage #2: (S)-2-chloropropanoic acid With hydrogen In N,N-dimethyl-formamide; mineral oil for 0.5h; Stage #3: With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 16h;	88%

: 55287-54-2
3,4-di-O-benzyl-2-acetamido-2-desoxy-α-benzyl-D-glucopyranoside

: 29617-66-1
(S)-2-chloropropanoic acid

: 75281-03-7, 79548-56-4
benzyl 2-acetamido-3,4-di-O-benzyl-6-O-(D-1-carboxyethyl)-2-deoxy-α-D-glucopyranoside

Conditions

Conditions	Yield
With sodium hydride In 1,4-dioxane at 65℃; for 1h;	87%

: 29617-66-1
(S)-2-chloropropanoic acid

: 709669-20-5
allyl 2-acetamido-2,4-dideoxy-4-fluoro-6-O-benzyl-α-D-glucopyranoside

: 709669-21-6
2-N-acetyl-1-α-allyl-6-O-benzyl-4-deoxy-4-fluoro-muramic acid

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 40℃; for 18h;	87%

: 29617-66-1
(S)-2-chloropropanoic acid

: 610314-17-5
N-Pmb-L-Orn(Z)-OMe

: 1252809-27-0
N-[(S)-2-chloropropionyl]-N-(p-methoxybenzyl)-L-orn(Z)-OMe

Conditions

Conditions	Yield
Stage #1: (S)-2-chloropropanoic acid With trichloroacetonitrile; triphenylphosphine In tetrahydrofuran at 0℃; for 0.5h; Stage #2: N-Pmb-L-Orn(Z)-OMe With methyloxirane In tetrahydrofuran for 48h;	87%

: 29617-66-1
(S)-2-chloropropanoic acid

: 1342305-87-6
N-p-propoxybenzyl-L-Phe-OMe

: 1342305-89-8
N-[(S)-2-chloropropionyl]-N-p-propoxybenzyl-L-Phe-OMe

Conditions

Conditions	Yield
Stage #1: (S)-2-chloropropanoic acid With trichloroacetonitrile; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 1h; Stage #2: N-p-propoxybenzyl-L-Phe-OMe With methyloxirane In tetrahydrofuran	87%

: 29617-66-1
(S)-2-chloropropanoic acid

: 66026-10-6
N-((4aR,6S,7R,8R,8aS)-6-(benzyloxy)-8-hydroxy-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-7-yl)acetamide

: 69323-67-7
(R)-2-(((4aR,6S,7R,8R,8aS)-7-acetamido-6-(benzyloxy)-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)propanoic acid

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20 - 50℃; for 18h; Inert atmosphere;	85%
With sodium hydride 1) THF, 2) 50 deg C, 18 h; Yield given. Multistep reaction;

: 29617-66-1
(S)-2-chloropropanoic acid

: 196214-70-7
N-phenethyl-L-Phe-OMe

: 1342305-90-1
N-[(S)-2-chloropropionyl]-N-phenethyl-L-Phe-OMe

Conditions

Conditions	Yield
Stage #1: (S)-2-chloropropanoic acid With trichloroacetonitrile; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 1h; Stage #2: N-phenethyl-L-Phe-OMe With methyloxirane In tetrahydrofuran	85%

: 29617-66-1
(S)-2-chloropropanoic acid

: 84034-62-8
N-((1R,2S,3R,4R,5R)-3-hydroxy-2-(trityloxy)-6,8-dioxabicyclo[3.2.1]octan-4-yl)acetamide

: (R)-2-(((1R,2S,3R,4R,5R)-4-acetamido-2-(trityloxy)-6,8-dioxabicyclo[3.2.1]octan-3-yl)oxy)propanoic acid

Conditions

Conditions	Yield
Stage #1: N-((1R,2S,3R,4R,5R)-3-hydroxy-2-(trityloxy)-6,8-dioxabicyclo[3.2.1]octan-4-yl)acetamide With sodium hydride In 1,4-dioxane; mineral oil at 20 - 45℃; for 0.416667h; Inert atmosphere; Stage #2: (S)-2-chloropropanoic acid In 1,4-dioxane; mineral oil at 90℃; for 1.5h; Inert atmosphere;	85%
Stage #1: N-((1R,2S,3R,4R,5R)-3-hydroxy-2-(trityloxy)-6,8-dioxabicyclo[3.2.1]octan-4-yl)acetamide With sodium hydride In 1,4-dioxane; mineral oil at 45℃; for 0.166667h; Stage #2: (S)-2-chloropropanoic acid In 1,4-dioxane; mineral oil at 90℃; for 0.5h; diastereoselective reaction;	70%

: 29617-66-1
(S)-2-chloropropanoic acid

: ethyl ((4aR,6S,7R,8R,8aS)-6-(benzyloxy)-8-hydroxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-7-yl)-1,4-dioxaspiro[4.5]decane-2-carboxamide

: (2R)-2-((4aR,6S,7R,8R,8aS)-6-(benzyloxy)-2-phenyl-7-(1,4-dioxaspiro[4.5]decane-2-carboxamido)hexahydropyrano[3,2-d][1,3]dioxin-8-yloxy)propanoic acid

Conditions

Conditions	Yield
Stage #1: ethyl ((4aR,6S,7R,8R,8aS)-6-(benzyloxy)-8-hydroxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-7-yl)-1,4-dioxaspiro[4.5]decane-2-carboxamide With sodium hydride In 1,4-dioxane; mineral oil at 95℃; for 1h; Stage #2: (S)-2-chloropropanoic acid In 1,4-dioxane; mineral oil at 65℃; for 17h;	85%

: 29617-66-1
(S)-2-chloropropanoic acid

: 81639-18-1
Benzyl 2-deoxy-4,6-O-isopropylidene-2-(tetracosanoylamino)-α-D-glucopyranoside

: 81639-19-2
Benzyl 3-O-(D-1-carboxyethyl)-2-deoxy-4,6-O-isopropylidene-2-(tetracosanoylamino)-α-D-glucopyranoside

Conditions

Conditions	Yield
With sodium hydride In 1,4-dioxane 1.) 90 deg C, 1 h, 2.) 60 deg, 5 h;	84%

: 29617-66-1
(S)-2-chloropropanoic acid

: 13343-63-0
benzyl 4,6-O-benzylidene-2-acetylamino-2-deoxy-α-D-glucopyranoside

: 2862-03-5
Benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-3-O-<(R)-1-carboxyethyl>-α-D-glucopyranoside

Conditions

Conditions	Yield
With sodium hydride In 1,4-dioxane at 60℃; for 0.833333h;	84%

: 29617-66-1
(S)-2-chloropropanoic acid

: 95068-66-9
allyl 2-N-acetamido-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranoside

: 364368-47-8
2-N-acetyl-1-β-O-allyl 4,6-O-isopropylidenemuramic acid

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 20h; Heating;	84%

(S)-(-)-2-Chloropropionic acid Chemical Properties

The Molecular Structure of (S)-(-)-2-Chloropropionic acid (CAS NO.29617-66-1):

Empirical Formula: C₃H₅ClO₂
Molecular Weight: 108.5236
CAS registry number: 29617-66-1
Appearance: Colourless Oil
IUPAC Name: (2S)-2-chloropropanoic acid
Nominal Mass: 108 Da
Average Mass: 108.5236 Da
Monoisotopic Mass: 107.997807 Da
Index of Refraction: 1.441
Molar Refractivity: 22.31 cm³
Molar Volume: 84.4 cm³
Surface Tension: 37.6 dyne/cm
Density: 1.285 g/cm³
Flash Point: 68.1 °C
Enthalpy of Vaporization: 46.87 kJ/mol
Boiling Point: 189 °C at 760 mmHg
Vapour Pressure: 0.26 mmHg at 25°C
InChI
InChI=1/C3H5ClO2/c1-2(4)3(5)6/h2H,1H3,(H,5,6)/t2-/m0/s1
Smiles
C([C@@H](Cl)C)(O)=O
Synonyms: (2S)-Chloropropanoic acid ; (S)-2-Chloropropanoic acid ; (S)-2-Chloropropionic acid ; 2(S)-Chloropropionic acid ; L-2-Chloropropanoic acid ; L-2-Chloropropionic acid ; alpha-L-Chloropropionic acid ; Propanoic acid, 2-chloro-, (S)- ; Propionic acid, 2-chloro-, L- (8CI)
Product Categories: Chiral Compounds;chiral;Miscellaneous Reagents;Building Blocks for Liquid Crystals;Carboxylic Acids (Chiral);Chiral Building Blocks;Chiral Compounds (Building Blocks for Liquid Crystals);Functional Materials;Synthetic Organic Chemistry

(S)-(-)-2-Chloropropionic acid Uses

(S)-(-)-2-Chloropropionic acid (CAS NO.29617-66-1) is used in the synthesis of muramic acid derivatives; Preparation of its ester and reaction with protected amino acid CESIUM salts to depsipeptides.

(S)-(-)-2-Chloropropionic acid Toxicity Data With Reference

1、RTECS#: CAS# 29617-66-1: UA2451950
2、LD50/LC50: RTECS: Not available.
3、Carcinogenicity: (S)-(-)-2-Chloropropionic Acid - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
4、Other: See actual entry in RTECS for complete information.

(S)-(-)-2-Chloropropionic acid Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 21/22-35
R21/22: Harmful in contact with skin and if swallowed
R35: Causes severe burns
Safety Statements: 23-26-28-36/37/39-45
S23: Do not breathe vapour
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S28: After contact with skin, wash immediately with plenty of soap-suds
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2511 8/PG 3
WGK Germany: 1
RTECS: UA2451950
HazardClass: 8
PackingGroup: III
HS Code: 29159080

(S)-(-)-2-Chloropropionic acid Specification

(1)Fire Fighting Measures of (S)-(-)-2-Chloropropionic acid (CAS NO.29617-66-1):
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use foam, dry chemical, or CARBON dioxide
(2)Handling and Storage of (S)-(-)-2-Chloropropionic Acid
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

Product Name

(S)-(-)-2-Chloropropionic acid

Synthetic route

(S)-(-)-2-Chloropropionic acid Chemical Properties

(S)-(-)-2-Chloropropionic acid Uses

(S)-(-)-2-Chloropropionic acid Toxicity Data With Reference

(S)-(-)-2-Chloropropionic acid Safety Profile

(S)-(-)-2-Chloropropionic acid Specification

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