(S)-3-N-Boc-aminopiperidine supplier

Name
(S)-3-N-Boc-aminopiperidine
EINECS 626-980-5
CAS No. 216854-23-8
Article Data3
CAS DataBase
Density 1.02 g/cm³
Solubility
Melting Point 122-127 °C
Formula C₁₀H₂₀N₂O₂
Boiling Point 304.8 °C at 760 mmHg
Molecular Weight 200.281
Flash Point 138.2 °C
Transport Information
Appearance
Safety 26-39
Risk Codes 37/38-41
Molecular Structure
Hazard Symbols Xi
Synonyms Carbamicacid, (3S)-3-piperidinyl-, 1,1-dimethylethyl ester (9CI);(S)-(-)-3-(tert-Butoxycarbonylamino)piperidine;(S)-3-tert-Butoxycarbonylaminopiperidine;(S)-tert-ButylN-[piperidin-3-yl]carbamate;tert-Butyl ((3S)-piperidin-3-yl)carbamate;
PSA 50.36000
LogP 1.98280

Synthetic route

: 92235-39-7
3(S)-<(butoxycarbonyl)amino>-2-oxopiperidine

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

Conditions

Conditions	Yield
With borane-THF In tetrahydrofuran at 0 - 25℃; for 6.75h;	30%

: 607376-86-3
(S)-2-(tert-butoxycarbonylamino)pentane-1,5-diyl dimethanesulfonate

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

Conditions

Conditions	Yield
With ammonium hydroxide In acetonitrile for 48h; Ambient temperature; Yield given;

: 56-86-0
L-glutamic acid

2-benzyloxycarbonylaminomethyl-4-benzyliden-Δ2-oxazolinone-(5): 2-benzyloxycarbonylaminomethyl-4-benzyliden-Δ2-oxazolinone-(5)

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: H2SO4 / 2 h / Heating 2: Et3N / dioxane; H2O / 2 h / 0 °C 3: NaBH4, CaCl2 / ethanol / 2 h / 0 °C 4: Et3N / CH2Cl2 / 1 h / -10 - 0 °C 5: aq. NH4OH / acetonitrile / 48 h / Ambient temperature View Scheme

: 6525-53-7, 16422-27-8, 40149-68-6
L-glutamic acid dimethyl ester

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: Et3N / dioxane; H2O / 2 h / 0 °C 2: NaBH4, CaCl2 / ethanol / 2 h / 0 °C 3: Et3N / CH2Cl2 / 1 h / -10 - 0 °C 4: aq. NH4OH / acetonitrile / 48 h / Ambient temperature View Scheme

: 59279-60-6, 130622-05-8
dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: NaBH4, CaCl2 / ethanol / 2 h / 0 °C 2: Et3N / CH2Cl2 / 1 h / -10 - 0 °C 3: aq. NH4OH / acetonitrile / 48 h / Ambient temperature View Scheme

: 162955-48-8
[(1S)-4-hydroxy-1-(hydroxymethyl)butyl]carbamic acid tert-butyl ester

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 1 h / -10 - 0 °C 2: aq. NH4OH / acetonitrile / 48 h / Ambient temperature View Scheme

: 1188914-98-8
1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: 1188915-59-4
tert-butyl (R)-1-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]piperidin-3-ylcarbamate

Conditions

Conditions	Yield
at 20℃;	100%

: 1527525-60-5
1-[5-(difluoromethyl)-6-fluoro-2-pyridyl]-6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridine

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: 1527525-62-7
tert-butyl N-[(3S)-1-[3-(difluoromethyl)-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]-3-piperidyl]carbamate

Conditions

Conditions	Yield
With 4-methyl-morpholine In 1-methyl-pyrrolidin-2-one at 100℃; Sealed tube;	100%

: 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: tert-butyl (S)-(1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl)carbamate

Conditions

Conditions	Yield
In i-Amyl alcohol at 130℃; under 760.051 Torr; for 0.833333h; Microwave irradiation;	100%

: 1188914-98-8
1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: 1188915-61-8
tert-butyl (S)-1-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]piperidin-3-ylcarbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;	100%

: 122-78-1
phenylacetaldehyde

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: 1361322-88-4
(S)-tert-butyl 1-phenethylpiperidin-3-ylcarbamate

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 4.25h;	99%

: 501-53-1
benzyl chloroformate

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: 876379-22-5
benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	99%
With triethylamine In dichloromethane at 0℃; for 1h;	95%
With triethylamine In ethyl acetate at 0℃; for 1h;	95%
With triethylamine In dichloromethane at 0 - 20℃; Product distribution / selectivity;	89%
With triethylamine In tetrahydrofuran at 20℃; for 0.5h;

: 776-74-9
Bromodiphenylmethane

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: (S)-tert-butyl (1-benzhydrylpiperidin-3-yl)carbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 60℃; for 14h;	94%

: 35432-36-1
2-methylpropane-1-sulfonyl chloride

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: 1270496-69-9
[(S)-1-(2-methyl-propane-1-sulfonyl)-piperidin-3-yl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	93%

: 110651-92-8
7-chloro-6-nitrothieno[3,2-b]pyridine

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: 1620011-13-3
tert-butyl [(3S)-1-(6-nitrothieno[3,2-b]pyridin-7-yl)piperidin-3-yl]carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 110℃; for 12h;	93%

: 2-chloro-4-((2-isopropyl-6-(4-methoxyphenyl)pyridin-4-yl)amino)pyrimidine-5-carboxamide

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: tert-butyl (S)-(1-(5-carbamoyl-4-((2-isopropyl-6-(4-methoxyphenyl)pyridin-4-yl)amino)pyrimidin-2-yl)piperidin-3-yl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 90℃; for 1h;	92%

: 1200130-66-0
4-chloro-9-(2-trimethylsilanyl-ethoxymethyl)-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: 1312753-95-9
(S)-tert-butyl 1-(6-cyano-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-dipyrido[2,3-b;4',3'-d]pyrrol-4-yl)piperidin-3-ylcarbamate

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 100℃; for 2h;	90%

: 870703-61-0
di-tert-butyl (6-bromo-2-pyridinyl)imidodicarbonate

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: (S)-tert-butyl 6-(3-aminopiperidin-1-yl)pyridin-2-ylcarbamate hydrochloride

Conditions

Conditions	Yield
Stage #1: di-tert-butyl (6-bromo-2-pyridinyl)imidodicarbonate; tert-butyl (S)-piperidin-3-yl-carbamate With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 95℃; for 7h; Inert atmosphere; Stage #2: With hydrogenchloride In 1,4-dioxane at 20℃; for 7h;	90%

: 50-00-0
formaldehyd

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: 902152-77-6
(S)-tert-butyl (1-methylpiperidin-3-yl)carbamate

Conditions

Conditions	Yield
With formic acid In 2-methyltetrahydrofuran; water at 80℃; for 0.75h;	90%

: 3-(6-fluoropyridin-2-yl)-1-methyl-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: (S)-tert-butyl 1-(6-(1-methyl-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)piperidin-3-ylcarbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethanol at 100℃; for 15h;	90%

: 1620012-10-3
5-iodo-6-nitro-1,2,3,4-tetrahydro-1,8-naphthyridine

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: 1620012-11-4
tert-butyl [(3S)-1-(3-nitro-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)piperidin-3-yl]carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 140℃; for 14h;	89%

: 41019-45-8
5-(4-chlorophenyl)-2-furoic acid

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: tert-butyl N-[(3S)-1-[5-(4-chlorophenyl)furan-2-carbonyl]piperidin-3-yl]carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h;	89%

: 2-chloro-4-((2,6-diisopropylpyridin-4-yl)amino)pyrimidine-5-carboxamide

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: tert-butyl (S)-(1-(5-carbamoyl-4-((2,6-diisopropylpyridin-4-yl)amino)pyrimidin-2-yl)piperidine -3-yl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 90℃; for 0.5h;	88%
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 90℃; for 0.5h;	88%

: 4-(3-bromoimidazo[1,2-a]pyridin-6-yl)benzoic acid

: 216854-23-8
tert-butyl (S)-piperidin-3-yl-carbamate

: (S)-tert-butyl (1-(4-(3-bromoimidazo[1,2-a]pyridin-6-yl)benzoyl)piperidin-4-yl)carbamate

Conditions

Conditions	Yield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 40℃; for 8h;	88%

(S)-3-N-Boc-aminopiperidine Chemical Properties

IUPAC Name: tert-butyl N-[(3S)-piperidin-3-yl]carbamate
Synonyms: (S)-TERT-BUTYL-PIPERIDIN-3-YLCARBAMATE;Carbamic acid, (3S)-3-piperidinyl-, 1,1-dimethylethyl ester (9CI);(S)-PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER;;(S)-3-N-BOC-AMINOPIPERIDINE;(S)-3-BOC-AMINOPIPERIDINE;CARBAMIC ACID, (3S)-3-PIPERIDINYL-, 1,1-DIMETHYLETHYL ESTER;(S)-(-)-3-TERT-BUTOXYCARBONYLAMINOPIPERIDINE;(S)-3-(TERT-BUTOXYCARBONYLAMINO)PIPERIDINE
The Molecular formula of (S)-3-N-Boc-aminopiperidine(216854-23-8): C₁₀H₂₀N₂O₂
The Molecular Weight of (S)-3-N-Boc-aminopiperidine(216854-23-8): 200.28
Molecular Structure :
Melting point: 122-127°C
alpha: -3 ^o (c=1, DMF)

(S)-3-N-Boc-aminopiperidine Safety Profile

The Hazard Codes of (S)-3-N-Boc-aminopiperidine(216854-23-8): Xi
The Risk Statements information of (S)-3-N-Boc-aminopiperidine(216854-23-8):
41: Risk of serious damage to eyes
37/38: Irritating to respiratory system and skin
The Safety Statements information of (S)-3-N-Boc-aminopiperidine(216854-23-8):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
39: Wear eye/face protection
WGK Germany: 3

Product Name

(S)-3-N-Boc-aminopiperidine

Synthetic route

(S)-3-N-Boc-aminopiperidine Chemical Properties

(S)-3-N-Boc-aminopiperidine Safety Profile

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