1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one supplier

Name
1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one
EINECS 263-731-6
CAS No. 62780-89-6
Article Data7
CAS DataBase
Density 1.257 g/cm³
Solubility 210 mg/L (20 ºC)
Melting Point 115-125 °C
Formula C₁₀H₁₁ClN₂O
Boiling Point 377oC
Molecular Weight 210.663
Flash Point
Transport Information
Appearance White to slightly beige powder
Safety 38-28A
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms 1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one;1-(3-Chloropropyl)-1,3-dihydrobenzimidazol-2-one;
PSA 37.79000
LogP 1.95850

Synthetic route

: 62780-84-1
1-(3-chloropropyl)-1,3-dihydro-3-(1-methylethenyl)-2H-benzimidazol-2-one

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

Conditions

Conditions	Yield
With phosphoric acid; propiononitrile at 75℃; for 4h; Concentration; Temperature;	92%
With hydrogenchloride In methanol; water at 20℃; Solvent; Reagent/catalyst;	90%
In hydrogenchloride; ethanol	9.5 parts (90%)

: 52099-72-6
1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one

: 109-70-6
1,3-chlorobromopropane

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

Conditions

Conditions	Yield
With sulfuric acid; sodium ethanolate 1) EtOH, reflux 4 h; 2) r.t., 2 h; Yield given. Multistep reaction;

: 100460-85-3
(2-Amino-phenyl)-(3-chloro-propyl)-carbamic acid ethyl ester

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

Conditions

Conditions	Yield
With calcium chloride at 210℃; for 1.5h; Yield given;

: 62781-00-4
1-(3-chloropropyl)2-nitroaniline

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: xylene / 18 h / Heating 2: H2 / 10percent Pd/C / methanol / 4 h 3: CaCl2 / 1.5 h / 210 °C View Scheme

: 100460-82-0
(3-Chloro-propyl)-(2-nitro-phenyl)-carbamic acid ethyl ester

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2 / 10percent Pd/C / methanol / 4 h 2: CaCl2 / 1.5 h / 210 °C View Scheme

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 74-88-4
methyl iodide

: 78056-57-2
1-(3-chloropropyl)-1,3-dihydro-3-methyl-2H-benzimidazol-2-one

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h;	98%
With sodium hydroxide In water; acetonitrile at 20℃; for 18h;	86%

: 36047-55-9
5-ethyl-5H-[1,2,4]triazino[5,6-b]indole-3-thiol

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 433261-68-8
1-(3-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one

Conditions

Conditions	Yield
Stage #1: 5-ethyl-5H-[1,2,4]triazino[5,6-b]indole-3-thiol With potassium hydroxide In water at 20℃; for 2h; Stage #2: 1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one In water at 90℃; for 24h;	93.9%

: 50-00-0
formaldehyd

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 1352949-10-0
1-(3-chloropropyl)-3-(hydroxymethyl)-1H-benzo[d]imidazol-2(3H)-one

Conditions

Conditions	Yield
With sodium acetate; acetic acid at 65℃; for 20h;	90%

: 121942-88-9
1-(6,11-dihydrodibenzothiepin-11-yl)piperazine

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 121942-94-7
1-(3-(4-(6,11-dihydrodibenzothiepin-11-yl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one

Conditions

Conditions	Yield
With triethylamine; potassium iodide In toluene Heating;	83%

: 23048-89-7
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)piperazine

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 121943-04-2
1-(3-(4-(8-chloro-10,11-dihydrodibenzothiepin-10-yl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one

Conditions

Conditions	Yield
With triethylamine; potassium iodide In toluene Heating;	76%

: 84461-65-4
2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 84461-66-5
1-{3-[4-(2-Methyl-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-1,3-dihydro-benzoimidazol-2-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide for 18h; Heating;	76%

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 52548-24-0
1-(2-chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazine

: 121943-02-0
1-(3-(4-(2-chloro-10,11-dihydrodibenzothiepin-10-yl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one

Conditions

Conditions	Yield
With triethylamine; potassium iodide In toluene Heating;	73%

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 65347-55-9
3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

: 1-{3-[4-(1H-Indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-1,3-dihydro-benzoimidazol-2-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide for 18h; Heating;	69%

: 27139-61-3
8-methylthio-10-piperazino-10,11-dihydrodibenzothiepin

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 121943-06-4
1-(3-(4-(8-(methylthio)-10,11-dihydrodibenzothiepin-10-yl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one

Conditions

Conditions	Yield
With triethylamine; potassium iodide In toluene Heating;	67%

: 4774-29-2
1-(10,11-dihydrodibenzo[b,f]thiepin-10-yl)piperazine

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 121943-00-8
1-(3-(4-(10,11-dihydrodibenzothiepin-10-yl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one

Conditions

Conditions	Yield
With triethylamine; potassium iodide In toluene Heating;	65%

: 121942-90-3
1-(2-methyl-6,11-dihydrodibenzothiepin-11-yl)piperazine

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 121942-96-9
1-(3-(4-(2-methyl-6,11-dihydrodibenzothiepin-11-yl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one

Conditions

Conditions	Yield
With triethylamine; potassium iodide In toluene Heating;	65%

: 841-77-0
diphenylmethylpiperazine

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 60607-34-3
oxatomide

Conditions

Conditions	Yield
With triethylamine; potassium iodide In toluene for 20h; Heating;	64%

: 17403-09-7
3-(4-piperidinyl)-1H-indole

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 97181-10-7
N-{3-[4-(3-indolyl)-piperidino]-propyl}-benzimidazolone

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide for 28h; Heating;	61%

: 69159-50-8
1-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)piperazine

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 121942-92-5
1-(3-(4-(10,11-dihydro-5H-dibenzocycloheptene-5-yl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one

Conditions

Conditions	Yield
With triethylamine; potassium iodide In toluene Heating;	60%

: 88536-11-2
4-propyloxypiperidine

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 509147-41-5
1-(3-(4-Butylpiperidine-1-yl)propyl)-1,3-dihydro-benzimidazol-2-one

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide	60%
With potassium carbonate; sodium iodide	60%

: 247571-59-1
5-allyl-5H-[1,2,4]triazino[5,6-b]indole-3-thiol

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 442653-38-5
1-(3-(5-allyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one

Conditions

Conditions	Yield
Stage #1: 5-allyl-5H-[1,2,4]triazino[5,6-b]indole-3-thiol With potassium hydroxide In water at 20℃; for 2h; Stage #2: 1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one In water at 90℃; for 24h;	55.2%

: 87233-69-0
1-(2-ethoxyethyl)-2-(1-piperazinyl)-1H-benzimidazole

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 127533-18-0
1-<3-<4-<1-(2-ethoxyethyl)-1H-benzimidazol-2-yl>-1-piperazinyl>propyl>-1,3-dihydro-2H-benzimidazol-2-one

Conditions

Conditions	Yield
With potassium carbonate In toluene for 14h; Heating;	53%

: 121942-91-4
1-(4,9-dihydrothieno<2,3-c>-2-benzothiepin-4-yl)piperazine

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 121942-98-1
1-(3-(4-(4,9-dihydrothieno<2,3-c>-2-benzothiepin-4-yl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one

Conditions

Conditions	Yield
With triethylamine; potassium iodide In toluene Heating;	50%

: 4-(indolyl-2)-piperidine

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 4-(indolyl-2)-1-benzimidazolonylpropyl-piperidine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide for 18h; Heating;	49%

: 304003-33-6
5-allyl-8-methyl-5H-[1,2,4]triazino[5,6-b]indole-3-thiol

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 1207874-69-8
1-(3-(5-allyl-8-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one

Conditions

Conditions	Yield
Stage #1: 5-allyl-8-methyl-5H-[1,2,4]triazino[5,6-b]indole-3-thiol With potassium hydroxide In water at 20℃; for 2h; Stage #2: 1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one In water at 90℃; for 24h;	47.6%

: 550369-44-3
4-ethylpiperidin-4-ol

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 1-[3-(4-Ethyl-4-hydroxypiperidin-1-yl)propyl]-1,3-dihydrobenzoimidazol-2-one

Conditions

Conditions	Yield
With sodium carbonate; sodium iodide In acetonitrile for 4h; Heating / reflux;	43%

: 84163-17-7
6-Methoxy-3-(4-piperidyl)-1,2-benzisoxazole hydrobromide

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 84243-01-6
1-{3-[4-(6-Methoxy-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-propyl}-1,3-dihydro-benzoimidazol-2-one

Conditions

Conditions	Yield
With sodium carbonate; potassium iodide In various solvent(s) at 117℃; for 16h;	37%

: 84163-16-6
4-(5-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 84242-99-9
1-{3-[4-(5-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-propyl}-1,3-dihydro-benzoimidazol-2-one

Conditions

Conditions	Yield
With sodium carbonate; potassium iodide In various solvent(s) at 117℃; for 8h;	36%

: 84163-15-5
5,6-dimethoxy-3-(4-piperidyl)-1,2-benzisoxazole hydrobromide

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 84243-16-3
1-{3-[4-(5,6-Dimethoxy-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-propyl}-1,3-dihydro-benzoimidazol-2-one

Conditions

Conditions	Yield
With sodium carbonate; potassium iodide In various solvent(s) at 117℃; for 6h;	28%

: 84163-13-3
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 84243-00-5
1-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-propyl}-1,3-dihydro-benzoimidazol-2-one

Conditions

Conditions	Yield
With sodium carbonate; potassium iodide In various solvent(s) at 117℃; for 12h;	27%

: 95742-20-4
4-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 84243-18-5
4-fluoro-3-<1-<3-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl>-4-piperidinyl>-1,2-benzisoxazole

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 90℃; for 6h;	26%

: 66611-26-5
5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 97181-09-4
1-{3-[4-(5-Methoxy-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-1,3-dihydro-benzoimidazol-2-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide for 6h; Heating;	25%

: 84163-22-4
3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 84231-49-2
1-[3-(4-Benzo[d]isoxazol-3-yl-piperidin-1-yl)-propyl]-1,3-dihydro-benzoimidazol-2-one

Conditions

Conditions	Yield
With sodium carbonate; potassium iodide In various solvent(s) at 117℃; for 6h;	23%

: 22093-38-5
4-Butyl-piperidin-4-ol

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 1-[3-(4-Butyl-4-hydroxypiperidin-1-yl)propyl]-1,3-dihydrobenzoimidazol-2-one

Conditions

Conditions	Yield
With sodium carbonate; sodium iodide In acetonitrile for 2h; Heating / reflux;	23%

1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one Chemical Properties

Molecular Structure of 2H-Benzimidazol-2-one,1-(3-chloropropyl)-1,3-dihydro- (CAS NO.62780-89-6):

Empirical Formula: C₁₀H₁₁ClN₂O
Molecular Weight: 210.6601
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 3
Polar Surface Area: 23.55 Å²
Index of Refraction: 1.57
Molar Refractivity: 55.05 cm³
Molar Volume: 167.5 cm³
Surface Tension: 43.8 dyne/cm
Density: 1.257 g/cm³
InChI
InChI=1/C10H11ClN2O/c11-6-3-7-13-9-5-2-1-4-8(9)12-10(13)14/h1-2,4-5H,3,6-7H2,(H,12,14)
Smiles
ClCCCn1c(=O)[nH]c2c1cccc2
Melting point: 115-125 °C
Water Solubility: 210 mg/L (20 ºC)

1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 38-28A

1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one Specification

2H-Benzimidazol-2-one,1-(3-chloropropyl)-1,3-dihydro- , with CAS number of 62780-89-6, can be called 3(3-Chloropropyl)-2,3-dihydro-1h-benzimidazole-2-one ; 1-(3-chloropropyl)-1,3-dihydro-2h-benzimidazol-2-one ; 1-(3-chloropropyl)-2-benzimidazolidinone ; 1-(3-chloropropyl)-1,3-dihydro-2h-benzimidezole-2-one ; timtec-bb sbb003442 ; 1-(3-chloropropyl)-1,3-dihydro-2h-benzimidazole-2-one ; balancemainlybromo ; ca90% .It is a white to slightly beige powder.

Product Name

1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one

Synthetic route

1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one Chemical Properties

1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one Safety Profile

1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one Specification

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